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4 results on '"Angeli K"'

1. Normal response to tumor necrosis factor-alpha and transforming growth factor-beta by keratinocytes in psoriasis

Author

Lionel Fry, J.J. Garioch, Angeli K. Malkani, Helgi Valdimarsson, B.S. Baker, A.V. Powles, and Helen M. Lewis

Subjects
Adult, Keratinocytes, medicine.medical_specialty, medicine.medical_treatment, Dermatology, Biochemistry, Receptors, Tumor Necrosis Factor, Transforming Growth Factor beta, In vivo, Internal medicine, Psoriasis, medicine, Humans, Lymphocytes, Molecular Biology, Skin, Cell Nucleus, biology, Tumor Necrosis Factor-alpha, Macrophages, Nuclear Proteins, Transforming growth factor beta, medicine.disease, In vitro, Endocrinology, Cytokine, biology.protein, Tumor necrosis factor alpha, Antibody, Cell Division, Transforming growth factor
Abstract

Normal and chronic plaque psoriatic keralinocyte cultures were tested for their in vitro response to 2–200 ng/nil TNF-α and 0.1–10 ng/ml TGF-β in a serum-free culture system. All normal and lesional psoriatic epidermal cell cultures showed a dose- and lime-dependent inhibition of growth in response to TNF-α and TGF-β. Inhibition in individual cultures was first seen at a concentration of 2 ng/ml for TNF-α and 0.1 ng/ml for TGF-β at day 2, but became significant at 20 ng/ml and 1 ng/ ml for TNF-α and TGF-β respectively at days 2-6. This effect was statistically significant at days 3–4 for the group of normal (TNF-α and TGF-β, n = 10, p

Published
1993

2. Leptospirosis, one neglected disease in rural Senegal

Author

Cédric Roqueplo, Angeli Kodjo, Jean‐Paul Demoncheaux, Pierre Scandola, Hubert Bassene, Georges Diatta, Cheikh Sokhna, Didier Raoult, Bernard Davoust, and Oleg Mediannikov

Subjects
animal, epidemiology, human, Leptospira spp., leptospirosis, Senegal, Veterinary medicine, SF600-1100
Abstract

Abstract A serological study was carried out in two Senegalese villages located in the Sine‐Saloum region in order to estimate the presence of anti‐leptospiral antibodies in humans and animals, and to identify the predominant serogroups. Seven hundred and forty‐nine serum samples were collected from humans (n = 545), dogs (n = 33), donkeys (n = 20), goats (n = 52), sheep (n = 43) and N’Dama cattle (n = 56), all originated from Dielmo and Ndiop villages. All samples were tested for different serovars of pathogenic Leptospira species by the microscopic agglutination test. Considering titres ≥ 1:100, 7.7% [CI 95:5.5 to 9.9] on the 545 human blood samples tested and 42.2% [CI95:35.4 to 48.9] on the 204 animal blood samples tested were found to be positive to one or more serovars. The results obtained indicate that the Australis serogroup is the most prevalent serogroup in human (67.3%) and cattle (27.3%). Serogroup Icterohaemorhagiae is the most frequent serogroup in goat (55.6%) and donkey (37.5%). Canicola (23.4%), Icterohaemorhagiae (21.1%) and Australis (12.5%) serogroups are the most prevalent serogroups in dogs. This study shows that diverse Leptospira serovars occur in a wide range of wild and domestic mammal species, as well as in humans in Senegal. However, further studies are needed to better understand the complexity of Leptospira epidemiology in Africa, identify the reservoirs of different serogroups and estimate its impact on livestock. Understanding the multi‐host epidemiology of leptospirosis is essential to control and prevent the disease.

Published
2019
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4. Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Author

EFSA Panel on Plant Protection Products and their residues (PPR), Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Marcel Leist, Alberto Mantovani, Pablo Menendez, Anna Price, Barbara Viviani, Arianna Chiusolo, Federica Ruffo, Andrea Terron, Ockleford, C., Adriaanse, P, Berny, P, Brock, T., Duquesne, S, Grilli, Sandro, Hernandez jerez, Af, Bennekou, Sh, Klein, M, Kuhl, T, Laskowski, R, Machera, K, Pelkonen, O, Pieper, S, Smith, R, Stemmer, M, Sundh, I, Teodorovic, I, Tiktak, A, Topping, Cj, Wolterink, G, Angeli, K, Fritsche, E, Leist, M, Mantovani, A, Menendez, P, Price, A, Viviani, B, Chiusolo, A, Ruffo, F, Terron, A, and Publica

Subjects
Environmental Risk Assessment, 0301 basic medicine, Test strategy, Epidemiology, AOP, Parkinson’s disease, childhood leukaemia, infant leukaemia, pesticides, epidemiology, Parkinson's disease, Veterinary (miscellaneous), Infant leukaemia, Context (language use), TP1-1185, Plant Science, Disease, Microbiology, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Documentation, childhood leukaemia, ddc:570, Adverse Outcome Pathway, Medicine, TX341-641, Pesticides, AOP, pesticide, Nutrition. Foods and food supply, infant leukaemia, business.industry, Chemical technology, Childhood leukaemia, pesticides, 3. Good health, Scientific Opinion, 030104 developmental biology, Systematic review, Conceptual framework, Risk analysis (engineering), Parkinson’s disease, epidemiology, Animal Science and Zoology, Parasitology, Biological plausibility, business, AOP, Parkinson's disease, childhood leukaemia, infant leukaemia, pesticides, epidemiology, 030217 neurology & neurosurgery, Food Science
Abstract

In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA)., This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1190/full

Published
2017

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