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Your search keyword '"Andrews, R. C."' showing total 24 results
Start Over Author "Andrews, R. C." Publisher wiley
24 results on '"Andrews, R. C."'

3. Adaptation of the By-Band randomized clinical trial to By-Band-Sleeve to include a new intervention and maintain relevance of the study to practice

Author

Rogers, C. A., Reeves, B. C., Byrne, J., Donovan, J. L., Mazza, G., Paramasivan, S., Andrews, R. C., Wordsworth, S., Thompson, J., Blazeby, J. M., Welbourn, R., Agrawal, S., Ajaz, S., Koak, Y., Ahmed, A., Fakih, N., Hakky, S., Moorthy, K., Purkayastha, S., Awad, S., Fareed, K., Leeder, P., Balupuri, S., Carr, W., Jennings, N., Small, P., Byrom, R., Davies, N., Carter, N., Knight, B., Somers, S., Charalampakis, V., Daskalakis, M., Nijar, R., Richardson, M., Singhal, R., Super, P., Clarke, M., Cota, A., Finlay, I., Dexter, S., Hayden, J., Mehta, S., Sarela, A., Kelly, J., Mahon, D., and Noble, H.

Subjects
medicine.medical_specialty, Sleeve gastrectomy, Evidence-based practice, Gastroplasty, medicine.medical_treatment, Psychological intervention, MEDLINE, Gastric Bypass, Gastric Band, 030209 endocrinology & metabolism, Pilot Projects, BTC (Bristol Trials Centre), law.invention, adaptive trial design, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), medicine, Roux-en-Y Gastric Bypass, Relevance (law), Humans, 030212 general & internal medicine, Adjustable gastric band, Practice Patterns, Physicians', Randomized Controlled Trials as Topic, business.industry, Patient Selection, By-Band-Sleeve study investigators, 11 Medical And Health Sciences, Original Articles, Sleeve Gastrectomy, 3. Good health, Surgery, Obesity, Morbid, Centre for Surgical Research, Physical therapy, Original Article, Severe obesity, business, Delivery of Health Care, RCT
Abstract

Background Recruitment into surgical RCTs can be threatened if new interventions available outside the trial compete with those being evaluated. Adapting the trial to include the new intervention may overcome this issue, yet this is not often done in surgery. This paper describes the challenges, rationale and methods for adapting an RCT to include a new intervention. Methods The By‐Band study was designed in the UK in 2009–2010 to compare the effectiveness of laparoscopic adjustable gastric band and Roux‐en‐Y gastric bypass for severe obesity. It contained a pilot phase to establish whether recruitment was possible, and the grant proposal specified that an adaptation to include sleeve gastrectomy would be considered if practice changed and recruitment was successful. Information on changing obesity surgery practice, updated evidence and expert opinion about trial design were used to inform the adaptation. Results The pilot phase recruited over 13 months in 2013–2014 and randomized 80 patients (79 anticipated). During this time, major changes in obesity practice in the UK were observed, with gastric band reducing from 32·6 to 15·8 per cent and sleeve gastrectomy increasing from 9·0 to 28·1 per cent. The evidence base had not changed markedly. The British Obesity and Metabolic Surgery Society and study oversight committees supported an adaptation to include sleeve gastrectomy, and a proposal to do so was approved by the funder. Conclusion Adaptation of a two‐group surgical RCT can allow evaluation of a third procedure and maintain relevance of the RCT to practice. It also optimizes the use of existing trial infrastructure to answer an additional important research question. Registration number: ISRCTN00786323 (http://www.isrctn.com/)., Something to consider

Published
2018

5. Exercise to preserve β‐cell function in recent‐onset Type 1 diabetes mellitus (EXTOD) – a randomized controlled pilot trial

Author

Narendran, P., primary, Jackson, N., additional, Daley, A., additional, Thompson, D., additional, Stokes, K., additional, Greenfield, S., additional, Charlton, M., additional, Curran, M., additional, Solomon, T. P. J., additional, Nouwen, A., additional, Lee, S. I., additional, Cooper, A. R., additional, Mostazir, M., additional, Taylor, R. S., additional, Kennedy, A., additional, and Andrews, R. C., additional

Published
2017
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9. ChemInform Abstract: 6‐Azasteroids: Structure‐Activity Relationships for Inhibition of Type 1 and 2 Human 5α‐Reductase and Human Adrenal 3β‐Hydroxy‐. delta.5‐steroid Dehydrogenase/3‐Keto‐δ5‐steroid Isomerase.

Author

FRYE, S. V., primary, HAFFNER, C. D., additional, MALONEY, P. R., additional, MOOK, R. A. JUN., additional, DORSEY, G. F. JUN., additional, HINER, R. N., additional, CRIBBS, C. M., additional, WHEELER, T. N., additional, RAY, J. A., additional, ANDREWS, R. C., additional, BATCHELOR, K. W., additional, BRAMSON, H. N., additional, STUART, J. D., additional, SCHWEIKER, S. L., additional, VAN ARNOLD, J., additional, CROOM, S., additional, BICKETT, D. M., additional, MOSS, M. L., additional, TIAN, G., additional, UNWALLA, R. J., additional, and LEE, F. W., additional

Published
1994
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