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1. Therapeutic Opportunities for Intestinal Angioectasia‐ Targeting PPARγ and Oxidative Stress

Author

Mayur Sarangdhar, Mary B. Yacyshyn, Andrew R. Gruenzel, Melinda A. Engevik, Nathaniel L. Harris, Bruce J. Aronow, and Bruce R. Yacyshyn

Subjects
Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
Abstract

Recurrent and acute bleeding from intestinal tract angioectasia (AEC) presents a major challenge for clinical intervention. Current treatments are empiric, with frequent poor clinical outcomes. Improvements in understanding the pathophysiology of these lesions will help guide treatment. Using data from the US Food and Drug Administration (FDA)’s Adverse Event Reporting System (FAERS), we analyzed 12 million patient reports to identify drugs inversely correlated with gastrointestinal bleeding and potentially limiting AEC severity. FAERS analysis revealed that drugs used in patients with diabetes and those targeting PPARγ‐related mechanisms were associated with decreased AEC phenotypes (P

Published
2021
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2. Therapeutic Opportunities for Intestinal Angioectasia‐ Targeting PPARγ and Oxidative Stress

Author

Melinda A. Engevik, Andrew R. Gruenzel, Nathaniel L. Harris, Mayur Sarangdhar, Bruce J. Aronow, Mary Beth Yacyshyn, and Bruce R. Yacyshyn

Subjects
Male, 030213 general clinical medicine, medicine.disease_cause, Bioinformatics, 030226 pharmacology & pharmacy, Colonic Diseases, Adverse Event Reporting System, 0302 clinical medicine, Data Mining, Gene Regulatory Networks, Protein Interaction Maps, RNA-Seq, General Pharmacology, Toxicology and Pharmaceutics, media_common, Systems Biology, lcsh:Public aspects of medicine, General Neuroscience, Colonoscopy, Articles, General Medicine, Middle Aged, respiratory system, Phenotype, Pathophysiology, Female, Gastrointestinal Hemorrhage, Adult, Drug, Colon, media_common.quotation_subject, education, Protective Agents, Article, General Biochemistry, Genetics and Molecular Biology, Rosiglitazone, 03 medical and health sciences, Diabetes mellitus, medicine, Humans, Telangiectasis, Aged, business.industry, Research, lcsh:RM1-950, lcsh:RA1-1270, medicine.disease, PPAR gamma, Oxidative Stress, lcsh:Therapeutics. Pharmacology, Case-Control Studies, Etiology, Endothelium, Vascular, Wound healing, business, Oxidative stress
Abstract

Recurrent and acute bleeding from intestinal tract angioectasia (AEC) presents a major challenge for clinical intervention. Current treatments are empiric, with frequent poor clinical outcomes. Improvements in understanding the pathophysiology of these lesions will help guide treatment. Using data from the US Food and Drug Administration (FDA)’s Adverse Event Reporting System (FAERS), we analyzed 12 million patient reports to identify drugs inversely correlated with gastrointestinal bleeding and potentially limiting AEC severity. FAERS analysis revealed that drugs used in patients with diabetes and those targeting PPARγ‐related mechanisms were associated with decreased AEC phenotypes (P

Published
2020

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