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2. Left Ventricular Assist Device as Bridge to Recovery for Anthracycline-Induced Terminal Heart Failure

Author

Jon M Appel, Peter Bo Hansen, Kåre Sander, Jacob E. Møller, Anders Krarup-Hansen, and Finn Gustafsson

Subjects
Heart transplantation, medicine.medical_specialty, Cardiotoxicity, Poor prognosis, Anthracycline, business.industry, medicine.medical_treatment, Emergency Nursing, medicine.disease, Surgery, Bridge (graph theory), Ventricular assist device, Internal medicine, Heart failure, Emergency Medicine, medicine, Cardiology, Sarcoma, Cardiology and Cardiovascular Medicine, business
Abstract

Anthracycline treatments are hampered by dose-related cardiotoxicity, frequently leading to heart failure (HF) with a very poor prognosis. The authors report a case of a 19-year-old man developing HF after anthracycline treatment for Ewing sarcoma. Despite medical treatment, his condition deteriorated to terminal HF, leading to implantation of a mechanical left ventricular assist device (LVAD). His heart function recovered, allowing explantation of the device 14 months after implantation. Heart transplantation is often contraindicated in the first years after treatment for cancers, and LVAD as "bridge to recovery" may be warranted in similar patients.

Published
2012
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