1. Poor sleep quality associates with self‐reported psychiatric and cardiometabolic symptoms independently of sleep timing patterns in a large sample of rural and urban workers
- Author
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Sidia M. Callegari-Jacques, Maria Paz Loayza Hidalgo, Ursula da Silveira Matte, Ana Maria Delgado Cunha, Fernanda dos Santos Pereira, Felipe Gutiérrez Carvalho, and André Comiran Tonon
- Subjects
Adult ,Male ,Rural Population ,Mediation (statistics) ,medicine.medical_specialty ,Adolescent ,Urban Population ,Cognitive Neuroscience ,Melatonin ,Pittsburgh Sleep Quality Index ,Young Adult ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Moderated mediation ,Sleep Initiation and Maintenance Disorders ,Epidemiology ,medicine ,Humans ,Circadian rhythm ,Psychiatry ,Aged ,business.industry ,Mental Disorders ,Chronotype ,General Medicine ,Middle Aged ,Sleep in non-human animals ,030228 respiratory system ,Cardiovascular Diseases ,Female ,Self Report ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Poor sleep associates with mental and cardiometabolic pathological outcomes. The participation of sleep timing features in the pathways by which this relationship occurs is not clear. This study aims to evaluate the interrelationship between sleep quality and self-reported psychiatric/cardiometabolic symptoms, considering mediation and moderation effects of sleep timing patterns, and urban versus rural work environment, respectively; and to verify the association between sleep quality and polymorphisms of AANAT, RORA and TIMELESS genes. An epidemiological survey was performed in a rural area in southern Brazil. Eight-hundred and twenty-nine subjects were evaluated for sleep quality using the Pittsburgh Sleep Quality Index, and sleep timing patterns using the Munich Chronotype Questionnaire. Work characteristics and psychiatric/cardiometabolic symptoms were assessed using a structured self-report questionnaire. Three polymorphisms of AANAT, RORA and TIMELESS (rs3760138, rs782931 and rs774045, respectively) were genotyped in blood samples. We found statistically significant associations of poor sleep quality with self-reported psychiatric symptoms (B = 0.382; 95% CI 0.289-0.476; adjusted p-value
- Published
- 2020
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