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66 results on '"An, Jong R."'

1. Antibacterial 3D graphene composite gel with polyaspartamide and tannic acid containing in situ generated Ag nanoparticle

Author

Ji-Heung Kim, Bo Wang, Ki D Park, Jong R. Moon, and Seungbae Ryu

Subjects
Antibacterial property, In situ, Materials science, Polymers and Plastics, Graphene, Composite number, Nanoparticle, General Chemistry, law.invention, chemistry.chemical_compound, chemistry, Chemical engineering, law, Tannic acid, Materials Chemistry, Ceramics and Composites, Composite material
Published
2020
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2. Rapid Evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality

Author

Plecko, D, Bennett, N, Martensson, J, Dam, TA, Entjes, R, Rettig, TCD, Dongelmans, DA, Boelens, AD, Rigter, S, Hendriks, SHA, de Jong, R, Kamps, MJA, Peters, M, Karakus, A, Gommers, D, Ramnarain, D, Wils, E-J, Achterberg, S, Nowitzky, R, Tempel, W, de Jager, CPC, Nooteboom, FGCA, Oostdijk, E, Koetsier, P, Cornet, AD, Reidinga, AC, de Ruijter, W, Bosman, RJ, Frenzel, T, Urlings-Strop, LC, de Jong, P, Smit, EGM, Cremer, OL, Mehagnoul-Schipper, DJ, Faber, HJ, Lens, J, Brunnekreef, GB, Festen-Spanjer, B, Dormans, T, de Bruin, DP, Lalisang, RCA, Vonk, SJJ, Haan, ME, Fleuren, LM, Thoral, PJ, Elbers, PWG, Bellomo, R, Plecko, D, Bennett, N, Martensson, J, Dam, TA, Entjes, R, Rettig, TCD, Dongelmans, DA, Boelens, AD, Rigter, S, Hendriks, SHA, de Jong, R, Kamps, MJA, Peters, M, Karakus, A, Gommers, D, Ramnarain, D, Wils, E-J, Achterberg, S, Nowitzky, R, Tempel, W, de Jager, CPC, Nooteboom, FGCA, Oostdijk, E, Koetsier, P, Cornet, AD, Reidinga, AC, de Ruijter, W, Bosman, RJ, Frenzel, T, Urlings-Strop, LC, de Jong, P, Smit, EGM, Cremer, OL, Mehagnoul-Schipper, DJ, Faber, HJ, Lens, J, Brunnekreef, GB, Festen-Spanjer, B, Dormans, T, de Bruin, DP, Lalisang, RCA, Vonk, SJJ, Haan, ME, Fleuren, LM, Thoral, PJ, Elbers, PWG, and Bellomo, R

Abstract

BACKGROUND: The prediction of in-hospital mortality for ICU patients with COVID-19 is fundamental to treatment and resource allocation. The main purpose was to develop an easily implemented score for such prediction. METHODS: This was an observational, multicenter, development, and validation study on a national critical care dataset of COVID-19 patients. A systematic literature review was performed to determine variables possibly important for COVID-19 mortality prediction. Using a logistic multivariable model with a LASSO penalty, we developed the Rapid Evaluation of Coronavirus Illness Severity (RECOILS) score and compared its performance against published scores. RESULTS: Our development (validation) cohort consisted of 1480 (937) adult patients from 14 (11) Dutch ICUs admitted between March 2020 and April 2021. Median age was 65 (65) years, 31% (26%) died in hospital, 74% (72%) were males, average length of ICU stay was 7.83 (10.25) days and average length of hospital stay was 15.90 (19.92) days. Age, platelets, PaO2/FiO2 ratio, pH, blood urea nitrogen, temperature, PaCO2, Glasgow Coma Scale (GCS) score measured within +/-24 h of ICU admission were used to develop the score. The AUROC of RECOILS score was 0.75 (CI 0.71-0.78) which was higher than that of any previously reported predictive scores (0.68 [CI 0.64-0.71], 0.61 [CI 0.58-0.66], 0.67 [CI 0.63-0.70], 0.70 [CI 0.67-0.74] for ISARIC 4C Mortality Score, SOFA, SAPS-III, and age, respectively). CONCLUSIONS: Using a large dataset from multiple Dutch ICUs, we developed a predictive score for mortality of COVID-19 patients admitted to ICU, which outperformed other predictive scores reported so far.

Published
2022

4. Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases

Author

Vries, M. R., primary, Ewing, M. M., additional, Jong, R. C. M., additional, MacArthur, M. R., additional, Karper, J. C., additional, Peters, E. A. B., additional, Nordzell, M., additional, Karabina, S. A. P., additional, Sexton, D., additional, Dahlbom, I., additional, Bergman, A., additional, Mitchell, J. R., additional, Frostegård, J., additional, Kuiper, J., additional, Ninio, E., additional, Jukema, J. W., additional, Pettersson, K., additional, and Quax, P. H. A., additional

Published
2021
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6. Host‐ and pathogen‐derived adjuvant coatings on protein nanoparticle vaccines

Author

Jong R. Kim, Ishatou Diambou, Timothy Z. Chang, Bao-Zhong Wang, and Julie A. Champion

Subjects
Research Report, 0301 basic medicine, Materials science, medicine.medical_treatment, Biomedical Engineering, Pharmaceutical Science, 02 engineering and technology, flagellin, Microbiology, Affinity maturation, 03 medical and health sciences, Immune system, adjuvant, vaccine, immunoglobulin M, medicine, affinity maturation, biology, nanoparticle, Immunogenicity, coating, Research Reports, 021001 nanoscience & nanotechnology, Molecular biology, 3. Good health, Ovalbumin, 030104 developmental biology, Immunoglobulin class switching, Immunoglobulin M, biology.protein, bacteria, Antibody, 0210 nano-technology, Adjuvant, Biotechnology
Abstract

Nanoparticulate and molecular adjuvants have shown great efficacy in enhancing immune responses, and the immunogenic vaccines of the future will most likely contain both. To investigate the immunostimulatory effects of molecular adjuvants on nanoparticle vaccines, we have designed ovalbumin (OVA) protein nanoparticles coated with two different adjuvants—flagellin (FliC) and immunoglobulin M (IgM). These proteins, derived from Salmonella and mice, respectively, are representatives of pathogen‐ and host‐derived molecules that can enhance immune responses. FliC‐coated OVA nanoparticles, soluble FliC (sFliC) admixed with OVA nanoparticles, IgM‐coated nanoparticles, and OVA‐coated nanoparticles were assessed for immunogenicity in an in vivo mouse immunization study. IgM coatings on nanoparticles significantly enhanced both antibody and T cell responses, and promoted IgG2a class switching but not affinity maturation. FliC‐coated nanoparticles and FliC‐admixed with nanoparticles both triggered IgG2a class switching, but only FliC‐coated nanoparticles enhanced antibody affinity maturation. Our findings that affinity maturation and class switching can be directed independently of one another suggest that adjuvant coatings on nanoparticles can be tailored to generate specific vaccine effector responses against different classes of pathogens.

Published
2017
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7. Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma

Author

Ooft, Marc Lucas, primary, van Ipenburg, Jolique, additional, van de Loo, Rob J. M., additional, de Jong, Rick, additional, Moelans, Cathy B., additional, de Bree, Remco, additional, de Herdt, Martine J., additional, Koljenović, Senada, additional, de Jong, R. Baatenburg, additional, Hardillo, J., additional, and Willems, Stefan Martin, additional

Published
2018
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8. Functional role of human NK cell receptor 2B4 (CD244) isoforms

Author

Jong R. Kim, Porunelloor A. Mathew, Nowland D. Bambard, Stephen O. Mathew, and Krithi K. Rao

Subjects
Interleukin 21, Lymphokine-activated killer cell, Janus kinase 3, Immunology, Interleukin 12, Immunology and Allergy, Cytotoxic T cell, CD48, Biology, Cell activation, Molecular biology, CD49b, Cell biology
Abstract

2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM/CD150), is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. Human NK cells express two isoforms of 2B4, h2B4-A and h2B4-B that differ in a small portion of the extracellular domain. In the present investigation, we have studied the functions of h2B4-A and h2B4-B. Our study demonstrated that these two isoforms differ in their binding affinity for CD48, which results in differential cytotoxic activity as well as intracellular calcium release by NK cells upon target cell recognition. Analysis of the predicted 3-D structure of the two isoforms showed conformational differences that could account for their differences in binding affinity to CD48. h2B4-A was able to mediate natural cytotoxicity against CD48-expressing K562 target cells and induce intracellular calcium release, whereas h2B4-B showed no effects. NK-92MI, U937, THP-1, KU812, primary monocytes, basophils and NK cells showed expression of both h2B4-A and h2B4-B whereas YT and IL-2-activated NK cells did not show any h2B4-B expression. Stimulation of NK cells through 2B4 resulted in decreased mRNA levels of both h2B4-A and h2B4-B indicating that down-regulation of 2B4 isoforms may be an important factor in controlling NK cell activation during immune responses.

Published
2009
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10. PLATO as it is: A legacy mission for Galactic archaeology

Author

Miglio, A., primary, Chiappini, C., additional, Mosser, B., additional, Davies, G. R., additional, Freeman, K., additional, Girardi, L., additional, Jofré, P., additional, Kawata, D., additional, Rendle, B. M., additional, Valentini, M., additional, Casagrande, L., additional, Chaplin, W. J., additional, Gilmore, G., additional, Hawkins, K., additional, Holl, B., additional, Appourchaux, T., additional, Belkacem, K., additional, Bossini, D., additional, Brogaard, K., additional, Goupil, M.‐J., additional, Montalbán, J., additional, Noels, A., additional, Anders, F., additional, Rodrigues, T., additional, Piotto, G., additional, Pollacco, D., additional, Rauer, H., additional, Prieto, C. Allende, additional, Avelino, P. P., additional, Babusiaux, C., additional, Barban, C., additional, Barbuy, B., additional, Basu, S., additional, Baudin, F., additional, Benomar, O., additional, Bienaymé, O., additional, Binney, J., additional, Bland‐Hawthorn, J., additional, Bressan, A., additional, Cacciari, C., additional, Campante, T. L., additional, Cassisi, S., additional, Christensen‐Dalsgaard, J., additional, Combes, F., additional, Creevey, O., additional, Cunha, M. S., additional, Jong, R. S., additional, Laverny, P., additional, Degl'Innocenti, S., additional, Deheuvels, S., additional, Depagne, É., additional, Ridder, J., additional, Matteo, P. Di, additional, Mauro, M. P. Di, additional, Dupret, M.‐A., additional, Eggenberger, P., additional, Elsworth, Y., additional, Famaey, B., additional, Feltzing, S., additional, García, R. A., additional, Gerhard, O., additional, Gibson, B. K., additional, Gizon, L., additional, Haywood, M., additional, Handberg, R., additional, Heiter, U., additional, Hekker, S., additional, Huber, D., additional, Ibata, R., additional, Katz, D., additional, Kawaler, S. D., additional, Kjeldsen, H., additional, Kurtz, D. W., additional, Lagarde, N., additional, Lebreton, Y., additional, Lund, M. N., additional, Majewski, S. R., additional, Marigo, P., additional, Martig, M., additional, Mathur, S., additional, Minchev, I., additional, Morel, T., additional, Ortolani, S., additional, Pinsonneault, M. H., additional, Plez, B., additional, Moroni, P. G. Prada, additional, Pricopi, D., additional, Recio‐Blanco, A., additional, Reylé, C., additional, Robin, A., additional, Roxburgh, I. W., additional, Salaris, M., additional, Santiago, B. X., additional, Schiavon, R., additional, Serenelli, A., additional, Sharma, S., additional, Aguirre, V. Silva, additional, Soubiran, C., additional, Steinmetz, M., additional, Stello, D., additional, Strassmeier, K. G., additional, Ventura, P., additional, Ventura, R., additional, Walton, N. A., additional, and Worley, C. C., additional

Published
2017
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12. Stellar science from a blue wavelength range

Author

Hansen, C. J., primary, Ludwig, H.‐G., additional, Seifert, W., additional, Koch, A., additional, Xu, W., additional, Caffau, E., additional, Christlieb, N., additional, Korn, A. J., additional, Lind, K., additional, Sbordone, L., additional, Ruchti, G., additional, Feltzing, S., additional, de Jong, R. S., additional, Barden, S., additional, and Schnurr, O., additional

Published
2015
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35. Disease-specific survival and locoregional control in tonsillar carcinoma

Author

MAK-KREGAR, S., primary, HILGERS, F. J. M., additional, LEVENDAG, P. C., additional, MANNI, J. J., additional, HART, A. A. M., additional, VISSER, O., additional, KNEGT, P. P. M., additional, MARRES, H. A. M., additional, BROEK, F. W. TEN, additional, BURLAGE, F. R., additional, BEEK, J. M. H., additional, and JONG, R. J. BAATENBURG, additional

Published
1996
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36. A Comprehensive 2-D Divertor Data Set from DIII-D for Edge Theory Validation

Author

Fenstermacher, M. E., primary, Allen, S. L., additional, Hill, D. N., additional, Leonard, A. W., additional, Lasnier, C. J., additional, Petrie, T. W., additional, Wood, R. D., additional, Brooks, N. H., additional, Buchenauer, D. A., additional, Carlstrom, T. N., additional, Cuthbertson, J. W., additional, Doyle, E. J., additional, Evans, T. E., additional, Garbet, P.-M., additional, Harvey, R. W., additional, Hyatt, A. W., additional, Isler, R. C., additional, Jackson, G. L., additional, James, R. A., additional, Jong, R. A., additional, Klepper, C. C., additional, Mahdavi, M. A., additional, Maingi, R., additional, Meyer, W. H., additional, Moyer, R. A., additional, Nilson, D. G., additional, Porter, G. D., additional, Rhodes, T. E., additional, Schaffer, M. J., additional, Staebler, G. M., additional, Stambaugh, R. D., additional, Stockdale, R. E., additional, Thomas, D. M., additional, Tugarinov, S., additional, Wade, M. R., additional, Watkins, J. G., additional, West, W. P., additional, and Whyte, D. G., additional

Published
1996
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