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Your search keyword '"Alvarado, Raquel"' showing total 18 results
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18 results on '"Alvarado, Raquel"'

4. Mepolizumab decreases tissue eosinophils while increasing type‐2 cytokines in eosinophilic chronic rhinosinusitis

Author

Walter, Sophie, primary, Ho, Jacqueline, additional, Alvarado, Raquel, additional, Smith, Greg, additional, Croucher, David R., additional, Liang, Sharron, additional, Grayson, Jessica W., additional, Mangussi‐Gomes, João, additional, Van Es, Simone L., additional, Earls, Peter, additional, Rimmer, Janet, additional, Campbell, Raewyn, additional, Kalish, Larry, additional, Sacks, Raymond, additional, and Harvey, Richard J., additional

Published
2022
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5. Empty Nose Syndrome Pathophysiology: A Systematic Review

Author

Kanjanawasee, Dichapong, primary, Campbell, Raewyn G., additional, Rimmer, Janet, additional, Alvarado, Raquel, additional, Kanjanaumporn, Jesada, additional, Snidvongs, Kornkiat, additional, Kalish, Larry, additional, Harvey, Richard J., additional, and Sacks, Raymond, additional

Published
2021
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16. A helminth cathelicidin‐like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

Author

Robinson, Mark W., primary, Alvarado, Raquel, additional, To, Joyce, additional, Hutchinson, Andrew T., additional, Dowdell, Stephanie N., additional, Lund, Maria, additional, Turnbull, Lynne, additional, Whitchurch, Cynthia B., additional, O'Brien, Bronwyn A., additional, Dalton, John P., additional, and Donnelly, Sheila, additional

Published
2012
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17. Empty Nose Syndrome Pathophysiology: A Systematic Review.

Author

Kanjanawasee D, Campbell RG, Rimmer J, Alvarado R, Kanjanaumporn J, Snidvongs K, Kalish L, Harvey RJ, and Sacks R

Subjects
Cross-Sectional Studies, Humans, Nose, Syndrome, Turbinates surgery, Nasal Obstruction complications, Nose Diseases surgery
Abstract

Objective: The pathophysiology of empty nose syndrome (ENS) remains unclear despite significant research. The pathophysiologic mechanism of ENS was systematically reviewed., Data Sources: MEDLINE and Embase., Review Methods: Data were systematically reviewed for studies that provided original data on pathophysiology., Results: A total of 2476 studies were screened, and 19 met the inclusion criteria: 13 case-control and 6 cross-sectional. Nine pathophysiologic themes were identified.• Demographics: ENS symptoms had no relationship with climatic factors.• Symptomatology: ENS patients demonstrated high symptom severity.• Mental health: Anxiety and depression including hyperventilation were reported in >50% of ENS patients and correlated with ENS symptom severity.• Anatomic features: Structural changes in response to turbinate surgery were similar between ENS and non-ENS patients.• Airflow analysis: Airflow parameters were similar between ENS and non-ENS patients after turbinate surgery. On computational fluid dynamic analysis, differences were found on multiple outcomes.• Diagnostic testing: The menthol detection test was impaired in ENS, and cotton placement in the airway improved ENS symptoms.• Cognitive function: Functional magnetic resonance imaging showed activation in emotional processing area during breathing.• Olfactory function: Subjective impairment was reported in ENS, but quantitative measures were similar to non-ENS patients.• Mucosal physiology/innate immunity: Turbinate histopathology in ENS showed a tissue-remodeling pattern. Nasal nitric oxide level was lower in ENS patients., Conclusion: There is evidence of high comorbid mental health disorders in ENS patients. An abnormal trigeminal-thermoreceptor response may be present in some patients. The influence of altered airflow and the evidence of surgery as the cause for ENS are unclear.

Published
2022
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18. Sinus Radiological Findings in General Asymptomatic Populations: A Systematic Review of Incidental Mucosal Changes.

Author

Razi B, Perkovic A, Alvarado R, Stroud A, Ho J, Kalish LH, Campbell RG, Sacks R, and Harvey RJ

Subjects
Chronic Disease, Humans, Maxilla, Cysts, Paranasal Sinuses, Sinusitis diagnostic imaging, Sinusitis epidemiology, Sinusitis surgery
Abstract

Objective: To determine the range of incidental mucosal changes in a general sinonasally asymptomatic population on radiology., Data Sources: Medline (1996-present) and Embase (1974-present) were searched on March 14, 2020, to identify articles that reported radiological sinus mucosal findings in asymptomatic population groups. Bibliographic search of included studies was conducted to identify additional articles., Review Methods: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Cochrane Handbook for Systematic Reviews of Interventions. A comprehensive search strategy was formulated and articles screened to extract data reporting Lund-Mackay (LM) score, presence of mucous retention cysts, and maxillary mucosal thickening. A random-effects model was used in meta-analysis., Results: A total of 950 articles were identified, of which 33 manuscripts met the inclusion criteria. The included studies involved 16,966 sinonasally asymptomatic subjects. The mean LM score was 2.24 (95% CI, 1.61-2.87), and an LM score of ≥4 in 14.71% (95% CI, 6.86-24.82%) was present across all general asymptomatic population groups. Mucous retention cysts were noted in 13% (95% CI, 8.33-18.55%) and maxillary mucosal thickening of ≥2 mm in 17.73% (95% CI, 8.67-29.08%)., Conclusion: The prevalence of incidental mucosal changes in a general asymptomatic population on radiology needs to be considered when making a diagnosis of chronic rhinosinusitis.

Published
2022
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