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Background. The main goal of the study was the analysis of somatostatin receptor (SSTR) expression on juvenile na- sopharyngeal angiofibroma (JNA) cells and a subsequent analysis of the utility of SST analog-based scintigraphy in JNA diagnostics. Methods. Nine JNA cases were analyzed. All tissue sam- ples were analyzed for the expression of SSTRs. In 2 cases, scintigraphy was performed after the intravenous (IV) adminis- tration of an SST analog. MRI of the craniofacial region was subsequently performed. Results. The SST analogues were accumulated in areas matching pathologic tissue in the nasopharynx. Immunohisto- chemical evaluation of the tissue samples proved the overex- pression of SSTRs. Conclusions. SSTRs are overexpressed on JNA cells. The SST analog 99m TC-octreotide is effectively bound to JNA cells. SST analogues might be used in the diagnostics and treatment of primary, recurrent, or residual JNA. V C 2011 Wiley Periodi- cals, Inc. Head Neck 33: 1739-1746, 2011

Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field

Summary Objective To determine the sensitivity and positive predictive value (PPV) of subtraction scintigraphy (SS) vs. ultrasonography (US) of the neck combined with rapid intact parathyroid hormone (iPTH) assay in US-guided fine-needle parathyroid aspirates in preoperative localization of parathyroid adenomas and in directing surgical approach. Design The results of SS for localization of parathyroid adenoma were determined in 121 patients with primary hyperparathyroidism (pHPT) and compared with findings at surgery and with the results of US alone (in patients without nodular goitre) and US in combination with the iPTH assay in US-guided fine-needle aspirates (FNAs) of suspicious parathyroid lesions (in patients with concomitant nodular goitre). Patients All 121 patients had biochemically documented pHPT; all were referred for first-time surgery. Measurements SS was performed with 99mTc-sestamibi and 99mTc-pertechnetate. High-resolution US of the neck was performed by a single endocrine surgeon and combined with US-guided FNAs of suspicious parathyroid lesions in all patients with nodular goitre (n = 43). Results The sensitivity and PPV of SS were significantly higher in patients without vs. with goitre (89·3% and 95·7%vs. 74·3% and 76·5%, respectively; P

BACKGROUND Carboxylated osteocalcin (Gla-OC) participates in bone remodeling, whereas the undercarboxylated form (Glu-OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu-OC and Gla-OC in nonobese, healthy obese, and prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. METHODS Nonobese (body mass index [BMI]