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Your search keyword '"Alexiou Athanasios"' showing total 38 results
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38 results on '"Alexiou Athanasios"'

2. Depression and type 2 diabetes: A causal relationship and mechanistic pathway

Author

Khawagi, Wael Y., primary, Al‐kuraishy, Hayder M., additional, Hussein, Nawar R., additional, Al‐Gareeb, Ali I., additional, Atef, Esraa, additional, Elhussieny, Omnya, additional, Alexiou, Athanasios, additional, Papadakis, Marios, additional, Jabir, Majid S., additional, Alshehri, Abdullah A., additional, Saad, Hebatallah M., additional, and Batiha, Gaber El‐Saber, additional

Published
2024
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7. Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease

Author

Abdul‐Rahman, Toufik, primary, Awuah, Wireko Andrew, additional, Mikhailova, Tatiana, additional, Kalmanovich, Jacob, additional, Mehta, Aashna, additional, Ng, Jyi Cheng, additional, Coghlan, Megan Ariel, additional, Zivcevska, Marija, additional, Tedeschi, Alexander J., additional, de Oliveira, Emerson Costa, additional, Kumar, Akinchita, additional, Cantu‐Herrera, Emiliano, additional, Lyndin, Mykola, additional, Sikora, Kateryna, additional, Alexiou, Athanasios, additional, Bilgrami, Anwar L., additional, Al‐Ghamdi, Khalid Mohammed, additional, Perveen, Asma, additional, Papadakis, Marios, additional, and Ashraf, Ghulam Md, additional

Published
2024
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10. The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

Author

Abdul‐Rahman, Toufik, primary, Ghosh, Shankhaneel, additional, Kalmanovich, Jacob B., additional, Awuah, Andrew Wireko, additional, Zivcevska, Marija, additional, Khalifa, Samar, additional, Bassey, Esther Edet, additional, Ali, Namarig Alnil, additional, Ferreira, Matheus Mendes dos Santos, additional, Umar, Tungki Pratama, additional, Garg, Neil, additional, Nweze, Victor Nnanna, additional, Inturu, Venkata Sai Sulekhya, additional, Abdelwahab, Maya Magdy, additional, Kurian, Sneha, additional, Alexiou, Athanasios, additional, Alfaleh, Mohammed, additional, Alqurashi, Thamer M. A., additional, and Ashraf, Ghulam Md, additional

Published
2023
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18. Diacerein modulates TLR4/ NF‐κB/IL‐1β and TRPC1/CHOP signalling pathways in gentamicin‐induced parotid toxicity in rats

Author

Ali, Dalia Mohamed, primary, Mahmoud, Mohamed H., additional, Rifaai, Rehab Ahmed, additional, Fawzy, Michael Atef, additional, Atta, Medhat, additional, Welson, Nermeen N., additional, Batiha, Gaber El‐Saber, additional, Alexiou, Athanasios, additional, Papadakis, Marios, additional, and Abdelzaher, Walaa Yehia, additional

Published
2023
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19. First confirmed case of multisystem inflammatory syndrome in adult in Egypt

Author

Elgohary, Mohamed Abdel‐Salam, primary, Mohamed, Mohamed Emam, additional, Hamada, Mahmoud Moustafa, additional, Fahim, Jackline S., additional, El‐Masry, Thanaa A., additional, Ibrahim, Ahmed Mohamed, additional, Taha, Ahmad Gad, additional, Seadawy, Mohamed G., additional, Alexiou, Athanasios, additional, Papadakis, Marios, additional, Batiha, Gaber El‐Saber, additional, and El‐Bouseary, Maisra M., additional

Published
2023
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23. SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

Author

Al‐kuraishy, Hayder M., primary, Hussien, Nawar R., additional, Al‐Niemi, Marwa S., additional, Fahad, Esraa H., additional, Al‐Buhadily, Ali K., additional, Al‐Gareeb, Ali I., additional, Al‐Hamash, Sadiq M., additional, Tsagkaris, Christos, additional, Papadakis, Marios, additional, Alexiou, Athanasios, additional, and Batiha, Gaber El‐Saber, additional

Published
2023
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32. Interrelation between extracellular vesicles miRNAs with chronic lung diseases

Author

Dhar, Rajib, primary, Mukherjee, Sayantanee, additional, Mukerjee, Nobendu, additional, Mukherjee, Dattatreya, additional, Devi, Arikketh, additional, Ashraf, Ghulam Md, additional, Alserihi, Raed F., additional, Tayeb, Hossam H., additional, Hashem, Anwar M., additional, Alexiou, Athanasios, additional, and Thorate, Nanasaheb, additional

Published
2022
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35. Targeting Oxidative Stress Mechanisms to Treat Alzheimer's and Parkinson's Disease: A Critical Review.

Author

Aborode AT, Pustake M, Awuah WA, Alwerdani M, Shah P, Yarlagadda R, Ahmad S, Silva Correia IF, Chandra A, Nansubuga EP, Abdul-Rahman T, Mehta A, Ali O, Amaka SO, Zuñiga YMH, Shkodina AD, Inya OC, Shen B, and Alexiou A

Subjects
Animals, Oxidative Stress physiology, Superoxide Dismutase metabolism, Alzheimer Disease pathology, Neurodegenerative Diseases pathology, Parkinson Disease pathology
Abstract

Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multiple potential of pathophysiological mechanisms contributing to neurodegenerative conditions, among which oxidative stress pathways appear to be suitable drug targets. The oxidative stress pathway has given rise to numerous novel pharmacological therapies that may provide a new avenue for neurodegenerative diseases. For example, SKQ (plastoquinone), MitoVitE, vitamin E, SOD mimic, MitoTEMPO (SOD mimetic), and bioactive molecules like curcumin and vitamin C have indeed been examined. To better understand how oxidative stress contributes to neurodegenerative diseases (such as Alzheimer's and Parkinson's), we analyzed the medicinal qualities of medicines that target markers in the cellular oxidative pathways. The specific pathway by which mitochondrial dysfunction causes neurodegeneration will require more investigation. An animal study should be carried out on medications that tackle cellular redox mechanisms but are not currently licensed for use in the management of neurodegenerative conditions., Competing Interests: The authors of this research disclose that they have no competing interests in its manuscript., (Copyright © 2022 Abdullahi Tunde Aborode et al.)

Published
2022
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36. Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope.

Author

Nabi SU, Khan A, Siddiqui EM, Rehman MU, Alshahrani S, Arafah A, Mehan S, Alsaffar RM, Alexiou A, and Shen B

Subjects
Humans, Mitochondria metabolism, Mitochondrial Dynamics, Mitophagy physiology, Neurons metabolism, Alzheimer Disease pathology
Abstract

Mitochondria play a critical role in neuron viability or death as it regulates energy metabolism and cell death pathways. They are essential for cellular energy metabolism, reactive oxygen species production, apoptosis, Ca ++ homeostasis, aging, and regeneration. Mitophagy and mitochondrial dynamics are thus essential processes in the quality control of mitochondria. Improvements in several fundamental features of mitochondrial biology in susceptible neurons of AD brains and the putative underlying mechanisms of such changes have made significant progress. AD's etiology has been reported by mitochondrial malfunction and oxidative damage. According to several recent articles, a continual fusion and fission balance of mitochondria is vital in their normal function maintenance. As a result, the shape and function of mitochondria are inextricably linked. This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Furthermore, the dynamics and roles of mitochondria are discussed with the link between mitochondrial malfunction and autophagy in AD has also been explored. In addition, recent research on mitochondrial dynamics and mitophagy in AD is also discussed in this review. It also goes into how these flaws affect mitochondrial quality control. Furthermore, advanced therapy techniques and lifestyle adjustments that lead to improved management of the dynamics have been demonstrated, hence improving the conditions that contribute to mitochondrial dysfunction in AD., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2022 Showkat Ul Nabi et al.)

Published
2022
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37. Natural Products for Neurodegeneration: Regulating Neurotrophic Signals.

Author

Uddin MS, Mamun AA, Rahman MM, Jeandet P, Alexiou A, Behl T, Sarwar MS, Sobarzo-Sánchez E, Ashraf GM, Sayed AA, Albadrani GM, Peluso I, and Abdel-Daim MM

Subjects
Animals, Biological Products pharmacology, Humans, Mice, Nerve Growth Factors, Rats, Biological Products therapeutic use, Neurodegenerative Diseases drug therapy
Abstract

Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effects., Competing Interests: The authors proclaim no competing interests., (Copyright © 2021 Md Sahab Uddin et al.)

Published
2021
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38. Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies.

Author

Ashraf GM, Ebada MA, Suhail M, Ali A, Uddin MS, Bilgrami AL, Perveen A, Husain A, Tarique M, Hafeez A, Alexiou A, Ahmad A, Kumar R, Banu N, Najda A, Sayed AA, Albadrani GM, Abdel-Daim MM, Peluso I, and Barreto GE

Subjects
Alzheimer Disease genetics, Alzheimer Disease pathology, Animals, Diabetes Mellitus genetics, Diabetes Mellitus pathology, Female, Humans, Male, Oxidative Stress, Risk Factors, Alzheimer Disease physiopathology, Alzheimer Disease therapy, Cognition, Diabetes Mellitus physiopathology, Diabetes Mellitus therapy, Sex Characteristics
Abstract

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (A β ) pathogenesis, emphasizing how these drugs act in the male and female brains., Competing Interests: The authors declare no conflict of interest., (Copyright © 2021 Ghulam Md Ashraf et al.)

Published
2021
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