1. Dose response of task‐specific upper limb training in people at least 6 months poststroke: A phase II, single‐blind, randomized, controlled trial
- Author
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Kendra M. Cherry-Allen, Rebecca L. Birkenmeier, Kimberly J. Waddell, Alexander W. Dromerick, Marghuretta D. Bland, Randolph J. Nudo, Catherine E. Lang, and Michael J. Strube
- Subjects
Male ,030506 rehabilitation ,medicine.medical_specialty ,Time Factors ,media_common.quotation_subject ,law.invention ,Task (project management) ,Neglect ,Upper Extremity ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Randomized controlled trial ,law ,medicine ,Humans ,Single-Blind Method ,Dosing ,Stroke ,Aged ,Paresis ,media_common ,Stroke Rehabilitation ,Middle Aged ,medicine.disease ,Exercise Therapy ,Clinical trial ,Outcome and Process Assessment, Health Care ,Hemiparesis ,Neurology ,Physical therapy ,Female ,Neurology (clinical) ,medicine.symptom ,0305 other medical science ,Psychology ,030217 neurology & neurosurgery - Abstract
OBJECTIVE The objectives of this work were to (1) determine whether higher doses of motor therapy in chronic poststroke hemiparesis result in better outcomes, compared to lower doses, and (2) evaluate potential modifiers of the dose-response relationship. METHODS Eighty-five adults with upper extremity paresis ≥6 months poststroke were randomized to one of four dose groups in this single-blind, parallel, randomized, control trial. The dosing parameter manipulated was amount of task-specific training, as indexed by the number of task repetitions. Groups received 3,200, 6,400, 9,600, or individualized maximum (IM) repetitions, during 1-hour sessions, 4 days/week for 8 weeks. The intervention was an individualized, progressive, task-specific upper-limb training program designed to improve upper-limb functional motor capacity. The primary outcome was the slope of the Action Research Arm Test (ARAT) during the intervention. Effects of dose and potential modifiers of the dose-response relationship were evaluated with hierarchical linear models. RESULTS ARAT scores for the 3,200, 9,600, and IM groups improved over time as indicated by slopes (ΔARAT/week, mean ± standard errors) of 0.40 ± 0.15, 0.31 ± 0.16, and 0.66 ± 0.14, respectively (p
- Published
- 2016