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5 results on '"Aleman, Julio"'

3. Biosensors: Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes (Adv. Sci. 5/2017)

Author

Shin, Su Ryon, primary, Kilic, Tugba, additional, Zhang, Yu Shrike, additional, Avci, Huseyin, additional, Hu, Ning, additional, Kim, Duckjin, additional, Branco, Cristina, additional, Aleman, Julio, additional, Massa, Solange, additional, Silvestri, Antonia, additional, Kang, Jian, additional, Desalvo, Anna, additional, Hussaini, Mohammed Abdullah, additional, Chae, Su-Kyoung, additional, Polini, Alessandro, additional, Bhise, Nupura, additional, Hussain, Mohammad Asif, additional, Lee, HeaYeon, additional, Dokmeci, Mehmet R., additional, and Khademhosseini, Ali, additional

Published
2017
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4. Label‐Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes

Author

Shin, Su Ryon, primary, Kilic, Tugba, additional, Zhang, Yu Shrike, additional, Avci, Huseyin, additional, Hu, Ning, additional, Kim, Duckjin, additional, Branco, Cristina, additional, Aleman, Julio, additional, Massa, Solange, additional, Silvestri, Antonia, additional, Kang, Jian, additional, Desalvo, Anna, additional, Hussaini, Mohammed Abdullah, additional, Chae, Su‐Kyoung, additional, Polini, Alessandro, additional, Bhise, Nupura, additional, Hussain, Mohammad Asif, additional, Lee, HeaYeon, additional, Dokmeci, Mehmet R., additional, and Khademhosseini, Ali, additional

Published
2017
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5. A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells.

Author

Aleman J and Skardal A

Subjects
A549 Cells, Colorectal Neoplasms diagnostic imaging, Equipment Design, HCT116 Cells, Hep G2 Cells, Human Umbilical Vein Endothelial Cells, Humans, Liver Neoplasms diagnostic imaging, Lung Neoplasms diagnostic imaging, Optical Imaging, Organoids diagnostic imaging, Organoids pathology, Colorectal Neoplasms pathology, Lab-On-A-Chip Devices, Liver Neoplasms secondary, Lung Neoplasms secondary
Abstract

Metastatic disease remains one of the primary reasons for cancer-related deaths, yet the majority of in vitro cancer models focus on the primary tumor sites. Here, we describe a metastasis-on-a-chip device that houses multiple bioengineered three-dimensional (3D) organoids, established by a 3D photopatterning technique employing extracellular matrix-derived hydrogel biomaterials. Specifically, cancer cells begin in colorectal cancer (CRC) organoid, which resides in a single microfluidic chamber connected to multiple downstream chambers in which liver, lung, and endothelial constructs are housed. Under recirculating fluid flow, tumor cells grow in the primary site, eventually enter circulation, and can be tracked via fluorescent imaging. Importantly, we describe that in the current version of this platform, HCT116 CRC cells preferentially home to the liver and lung constructs; the corresponding organs of which CRC metastases arise the most in human patients. We believe that in subsequent studies this platform can be implemented to better understand the mechanisms underlying metastasis, perhaps resulting in the identification of targets for intervention., (© 2018 Wiley Periodicals, Inc.)

Published
2019
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