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2. Genetic Testing in Parkinson's Disease

Author

Pal, Gian, primary, Cook, Lola, additional, Schulze, Jeanine, additional, Verbrugge, Jennifer, additional, Alcalay, Roy N., additional, Merello, Marcelo, additional, Sue, Carolyn M., additional, Bardien, Soraya, additional, Bonifati, Vincenzo, additional, Chung, Sun Ju, additional, Foroud, Tatiana, additional, Gatto, Emilia, additional, Hall, Anne, additional, Hattori, Nobutaka, additional, Lynch, Tim, additional, Marder, Karen, additional, Mascalzoni, Deborah, additional, Novaković, Ivana, additional, Thaler, Avner, additional, Raymond, Deborah, additional, Salari, Mehri, additional, Shalash, Ali, additional, Suchowersky, Oksana, additional, Mencacci, Niccolò E., additional, Simuni, Tanya, additional, Saunders‐Pullman, Rachel, additional, and Klein, Christine, additional

Published
2023
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3. Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort

Author

Vollstedt, Eva-Juliane, Schaake, Susen, Lohmann, Katja, Padmanabhan, Shalini, Brice, Alexis, Lesage, Suzanne, Tesson, Christelle, Vidailhet, Marie, Wurster, Isabel, Hentati, Faycel, Mirelman, Anat, Giladi, Nir, Marder, Karen, Waters, Cheryl, Fahn, Stanley, Kasten, Meike, Brüggemann, Norbert, Borsche, Max, Foroud, Tatiana, Tolosa, Eduardo, Garrido, Alicia, Annesi, Grazia, Gagliardi, Monica, Bozi, Maria, Stefanis, Leonidas, Ferreira, Joaquim J, Correia Guedes, Leonor, Avenali, Micol, Petrucci, Simona, Clark, Lorraine, Fedotova, Ekaterina Y, Abramycheva, Natalya Y, Alvarez, Victoria, Menéndez-González, Manuel, Jesús Maestre, Silvia, Gómez-Garre, Pilar, Mir, Pablo, Belin, Andrea Carmine, Ran, Caroline, Lin, Chin-Hsien, Kuo, Ming-Che, Crosiers, David, Wszolek, Zbigniew K, Ross, Owen A, Jankovic, Joseph, Nishioka, Kenya, Funayama, Manabu, Clarimon, Jordi, Williams-Gray, Caroline H, Camacho, Marta, Cornejo-Olivas, Mario, Torres-Ramirez, Luis, Wu, Yih-Ru, Lee-Chen, Guey-Jen, Morgadinho, Ana, Pulkes, Teeratorn, Termsarasab, Pichet, Berg, Daniela, Kuhlenbäumer, Gregor, Kühn, Andrea A, Borngräber, Friederike, De Michele, Giuseppe, De Rosa, Anna, Zimprich, Alexander, Puschmann, Andreas, Mellick, George D, Dorszewska, Jolanta, Carr, Jonathan, Ferese, Rosangela, Gambardella, Stefano, Chase, Bruce, Markopoulou, Katerina, Satake, Wataru, Toda, Tatsushi, Rossi, Malco, Merello, Marcelo, Lynch, Timothy, Olszewska, Diana A, Lim, Shen-Yang, Ahmad-Annuar, Azlina, Tan, Ai Huey, Al-Mubarak, Bashayer, Hanagasi, Hasmet, Koziorowski, Dariusz, Ertan, Sibel, Genç, Gençer, De Carvalho Aguiar, Patricia, Barkhuizen, Melinda, Pimentel, Marcia MG, Saunders-Pullman, Rachel, Van De Warrenburg, Bart, Bressman, Susan, Toft, Mathias, Appel-Cresswell, Silke, Lang, Anthony E, Skorvanek, Matej, Boon, Agnita JW, Krüger, Rejko, Sammler, Esther M, Tumas, Vitor, Zhang, Bao-Rong, Garraux, Gaetan, Chung, Sun Ju, Kim, Yun Joong, Winkelmann, Juliane, Sue, Carolyn M, Tan, Eng-King, Damásio, Joana, Klivényi, Péter, Kostic, Vladimir S, Arkadir, David, Martikainen, Mika, Borges, Vanderci, Hertz, Jens Michael, Brighina, Laura, Spitz, Mariana, Suchowersky, Oksana, Riess, Olaf, Das, Parimal, Mollenhauer, Brit, Gatto, Emilia M, Petersen, Maria Skaalum, Hattori, Nobutaka, Wu, Ruey-Meei, Illarioshkin, Sergey N, Valente, Enza Maria, Aasly, Jan O, Aasly, Anna, Alcalay, Roy N, Thaler, Avner, Farrer, Matthew J, Brockmann, Kathrin, Corvol, Jean-Christophe, Klein, Christine, MJFF Global Genetic Parkinson's Disease Study Group, Vollstedt, Ej, Schaake, S, Lohmann, K, Padmanabhan, S, Brice, A, Lesage, S, Tesson, C, Vidailhet, M, Wurster, I, Hentati, F, Mirelman, A, Giladi, N, Marder, K, Waters, C, Fahn, S, Kasten, M, Brüggemann, N, Borsche, M, Foroud, T, Tolosa, E, Garrido, A, Annesi, G, Gagliardi, M, Bozi, M, Stefanis, L, Ferreira, Jj, Correia Guedes, L, Avenali, M, Petrucci, S, Clark, L, Fedotova, Ey, Abramycheva, Ny, Alvarez, V, Menéndez-González, M, Jesús Maestre, S, Gómez-Garre, P, Mir, P, Belin, Ac, Ran, C, Lin, Ch, Kuo, Mc, Crosiers, D, Wszolek, Zk, Ross, Oa, Jankovic, J, Nishioka, K, Funayama, M, Clarimon, J, Williams-Gray, Ch, Camacho, M, Cornejo-Olivas, M, Torres-Ramirez, L, Wu, Yr, Lee-Chen, Gj, Morgadinho, A, Pulkes, T, Termsarasab, P, Berg, D, Kuhlenbäumer, G, Kühn, Aa, Borngräber, F, de Michele, G, De Rosa, A, Zimprich, A, Puschmann, A, Mellick, Gd, Dorszewska, J, Carr, J, Ferese, R, Gambardella, S, Chase, B, Markopoulou, K, Satake, W, Toda, T, Rossi, M, Merello, M, Lynch, T, Olszewska, Da, Lim, Sy, Ahmad-Annuar, A, Tan, Ah, Al-Mubarak, B, Hanagasi, H, Koziorowski, D, Ertan, S, Genç, G, de Carvalho Aguiar, P, Barkhuizen, M, Pimentel, Mmg, Saunders-Pullman, R, van de Warrenburg, B, Bressman, S, Toft, M, Appel-Cresswell, S, Lang, Ae, Skorvanek, M, Boon, Ajw, Krüger, R, Sammler, Em, Tu, Repositório da Universidade de Lisboa, Clinical Genetics, Neurology, Internal Medicine, Aasly, Anna, Aasly, Jan O, Abramycheva, Natalya Y, Ahmad-Annuar, Azlina, Albanese, Alberto, Alcalay, Roy N, Aldakheel, Amaal, Alkhairallah, Thamer, Al-Mubarak, Bashayer, Al-Tassan, Nada, Alvarez, Victoria, Amami, Paolo, Annesi, Grazia, Appel-Cresswell, Silke, Leite, Marco Antonio Araujo, Arkadir, David, Avenali, Micol, Ferraz, Henrique Ballalai, Bardien, Soraya, Barkhuizen, Melinda, Barrett, Matthew J, Başak, A Nazlı, Berg, Daniela, Bilgic, Basar, Bloem, Bastiaan R, Bonifati, Vincenzo, Boon, Agnita J W, Borges, Vanderci, Borngräber, Friederike, Borsche, Max, Bozi, Maria, Bressman, Susan, Brice, Alexis, Brighina, Laura, Brockmann, Kathrin, Brüggemann, Norbert, Camacho, Marta, Belin, Andrea Carmine, Carr, Jonathan, Cesarini, Martin Emiliano, Cornejo-Olivas, Mario, Chase, Bruce, Chung, Sun Ju, Guedes, Leonor Correia, Clarimon, Jordi, Clark, Lorraine, Corvol, Jean-Christophe, Crosiers, David, Das, Parimal, de Carvalho Aguiar, Patricia, Damásio, Joana, de Michele, Giuseppe, De Rosa, Anna, Dieguez, Elena, Dorszewska, Jolanta, Ertan, Sibel, Fahn, Stanley, Farrer, Matthew J, Fedotova, Ekaterina Y, Ferese, Rosangela, Ferreira, Joaquim J, Foroud, Tatiana, Funayama, Manabu, Fung, Victor S C, Gagliardi, Monica, Gambardella, Stefano, Garraux, Gaetan, Garrido, Alicia, Gatto, Emilia M, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycel, Hertz, Jens Michael, Illarioshkin, Sergey N, Jankovic, Joseph, Januario, Cristina, Maestre, Silvia Jesús, Kaasinen, Valtteri, Kasten, Meike, Kataoka, Hiroshi, Kievit, Anneke A, Kim, Yun Joong, Klein, Christine, Klivényi, Péter, Kostic, Vladimir S, Koziorowski, Dariusz, Krüger, Rejko, Kühn, Andrea, Kuhlenbäumer, Gregor, Kuo, Ming-Che, Lang, Anthony E, Lee-Chen, Guey-Jen, Lesage, Suzanne, Lim, Jia Lun, Lim, Shen-Yang, Lin, Chin-Hsien, Lohmann, Katja, Lynch, Timothy, Marder, Karen, Markopoulou, Katerina, Martikainen, Mika, May, Patrick, McCarthy, Allan, Mellick, George D, Menéndez-González, Manuel, Merello, Marcelo, Mir, Pablo, Mirelman, Anat, Mollenhauer, Brit, Briceno, Hugo Morales, Morgadinho, Ana, Morris, Huw, Mosejova, Alexandra, Nishioka, Kenya, Çakmak, Özgür Öztop, Olszewska, Diana A, Orr-Urtreger, Avi, Pachchek, Sinthuja, Padmanabhan, Shalini, Periñán, Maria Teresa, Petrucci, Simona, Pimentel, Marcia M G, Procopio, Radha, Pulkes, Teeratorn, Puschmann, Andreas, Ran, Caroline, Riess, Olaf, Ross, Owen A, Rossi, Malco, Ruiz-Martinez, Javier, Sammler, Esther M, Pereira, João Santos, Satake, Wataru, Saunders-Pullman, Rachel, Schaake, Susen, Petersen, Maria Skaalum, Skorvanek, Matej, Stefanis, Leonidas, Soto-Beasley, Alexandra I, Sousa, Mário, Spitz, Mariana, Suchowersky, Oksana, Sue, Carolyn M, Tan, Ai Huey, Tan, Eng-King, Thaler, Avner, Tepgeç, Fatih, Termsarasab, Pichet, Tesson, Christelle, Toda, Tatsushi, Toft, Mathias, Tolosa, Eduardo, Torres-Ramirez, Luis, Tumas, Vitor, Uyguner, Oya, Valente, Enza Maria, van de Warrenburg, Bart, Vidailhet, Marie, Vollstedt, Eva-Juliane, Walton, Ronald L, Waters, Cheryl, Williams-Gray, Caroline H, Winkelmann, Juliane, Wu, Yih-Ru, Wurster, Isabel, Wszolek, Zbigniew K, Wu, Ruey-Meei, Zhang, Bao-Rong, Zimprich, Alexander, Vollstedt, Eva-Juliane [0000-0002-6898-9201], Lohmann, Katja [0000-0002-5121-1460], Mirelman, Anat [0000-0002-1520-2292], Brüggemann, Norbert [0000-0001-5969-6899], Borsche, Max [0000-0002-9651-5986], Tolosa, Eduardo [0000-0002-3781-0854], Ferreira, Joaquim J [0000-0003-3950-5113], Alvarez, Victoria [0000-0002-1916-2523], Mir, Pablo [0000-0003-1656-302X], Kuo, Ming-Che [0000-0003-3688-0225], Ross, Owen A [0000-0003-4813-756X], Nishioka, Kenya [0000-0001-8607-9757], Williams-Gray, Caroline H [0000-0002-2648-9743], Camacho, Marta [0000-0002-1490-5703], Cornejo-Olivas, Mario [0000-0001-6313-5680], Wu, Yih-Ru [0000-0003-1191-2542], Termsarasab, Pichet [0000-0002-3260-3119], Borngräber, Friederike [0000-0001-9650-6820], Zimprich, Alexander [0000-0002-1668-5177], Gambardella, Stefano [0000-0002-3727-4502], Chase, Bruce [0000-0001-5491-7242], Olszewska, Diana A [0000-0002-1814-8834], Tan, Ai Huey [0000-0002-2979-3839], Barkhuizen, Melinda [0000-0002-9952-7085], Appel-Cresswell, Silke [0000-0002-5986-1468], Skorvanek, Matej [0000-0001-5497-8715], Sammler, Esther M [0000-0003-3218-7116], Zhang, Bao-Rong [0000-0002-8099-7407], Chung, Sun Ju [0000-0003-4118-8233], Apollo - University of Cambridge Repository, and MJFF Global Genetic Parkinson's Disease Study Group

Subjects
parkinson's disease, monogenic pd, monogenic PD, Parkinson's disease, Monogenic PD, Parkinson Disease, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], ddc, Neurology, genetics [Parkinson Disease], Mutation, Humans, Human medicine, ddc:610, Neurology (clinical), Research Article, Research Articles
Abstract

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014

Published
2023

4. Patterns of TDP ‐43 Deposition in Brains withLRRK2 G2019SMutations

Author

Agin‐Liebes, Julian, primary, Hickman, Richard A., additional, Vonsattel, Jean Paul, additional, Faust, Phyllis L., additional, Flowers, Xena, additional, Utkina Sosunova, Irina, additional, Ntiri, Joel, additional, Mayeux, Richard, additional, Surface, Matthew, additional, Marder, Karen, additional, Fahn, Stanley, additional, Przedborski, Serge, additional, and Alcalay, Roy N., additional

Published
2023
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5. Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

Author

Outeiro, Tiago F., primary, Alcalay, Roy N., additional, Antonini, Angelo, additional, Attems, Johannes, additional, Bonifati, Vincenzo, additional, Cardoso, Francisco, additional, Chesselet, Marie‐Françoise, additional, Hardy, John, additional, Madeo, Graziella, additional, McKeith, Ian, additional, Mollenhauer, Brit, additional, Moore, Darren J., additional, Rascol, Olivier, additional, Schlossmacher, Michael G., additional, Soreq, Hermona, additional, Stefanis, Leonidas, additional, and Ferreira, Joaquim J., additional

Published
2023
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7. Polygenic Parkinson's Disease Genetic Risk Score as Risk Modifier of Parkinsonism in Gaucher Disease

Author

Blauwendraat, Cornelis, primary, Tayebi, Nahid, additional, Woo, Elizabeth Geena, additional, Lopez, Grisel, additional, Fierro, Luca, additional, Toffoli, Marco, additional, Limbachiya, Naomi, additional, Hughes, Derralynn, additional, Pitz, Vanessa, additional, Patel, Dhairya, additional, Vitale, Dan, additional, Koretsky, Mathew J., additional, Hernandez, Dena, additional, Real, Raquel, additional, Alcalay, Roy N., additional, Nalls, Mike A., additional, Morris, Huw R., additional, Schapira, Anthony H.V., additional, Balwani, Manisha, additional, and Sidransky, Ellen, additional

Published
2023
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8. Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

Author

Outeiro, Tiago F., Alcalay, Roy N., Antonini, Angelo, Attems, Johannes, Bonifati, Vincenzo, Cardoso, Francisco, Chesselet, Marie-Françoise, Hardy, John, Madeo, Graziella, McKeith, Ian, Mollenhauer, Brit, Moore, Darren J., Rascol, Olivier, Schlossmacher, Michael G., Soreq, Hermona, Stefanis, Leonidas, Ferreira, Joaquim J., Outeiro, Tiago F., Alcalay, Roy N., Antonini, Angelo, Attems, Johannes, Bonifati, Vincenzo, Cardoso, Francisco, Chesselet, Marie-Françoise, Hardy, John, Madeo, Graziella, McKeith, Ian, Mollenhauer, Brit, Moore, Darren J., Rascol, Olivier, Schlossmacher, Michael G., Soreq, Hermona, Stefanis, Leonidas, and Ferreira, Joaquim J.

Abstract

Background: More than 200 years after James Parkinsondescribed a clinical syndrome based on his astute observations, Parkinson's disease (PD) has evolved into a complex entity, akin to the heterogeneity of other complex human syndromes of the central nervous system such as dementia, motor neuron disease, multiple sclerosis, and epilepsy. Clinicians, pathologists, and basic science researchers evolved arrange of concepts andcriteria for the clinical, genetic, mechanistic, and neuropathological characterization of what, in their best judgment, constitutes PD. However, these specialists have generated and used criteria that are not necessarily aligned between their different operational definitions, which may hinder progress in solving the riddle of the distinct forms of PD and ultimately how to treat them. Objective: This task force has identified current in consistencies between the definitions of PD and its diverse variants in different domains: clinical criteria, neuropathological classification, genetic subtyping, biomarker signatures, and mechanisms of disease. This initial effort for “defining the riddle” will lay the foundation for future attempts to better define the range of PD and its variants, as has been done and implemented for other heterogeneous neurological syndromes, such as stroke and peripheral neuropathy. We strongly advocate for a more systematic and evidence-based integration of our diverse disciplines by looking at well-defined variants of the syndrome of PD. Conclusion: Accuracy in defining endophenotypes of “typical PD” across these different but interrelated disciplines will enable better definition of variants and their stratification in therapeutic trials, a prerequisite for breakthroughs in the era of precision medicine. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on beh

Published
2023

9. Reply to: “Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked withGBA1Mutations”?

Author

Surface, Matthew, primary, Balwani, Manisha, additional, Waters, Cheryl, additional, Haimovich, Alexander, additional, Gan‐Or, Ziv, additional, Marder, Karen S., additional, Hsieh, Tammy, additional, Song, Linxia, additional, Padmanabhan, Shalini, additional, Hsieh, Frank, additional, Merchant, Kalpana M., additional, and Alcalay, Roy N., additional

Published
2022
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10. Reply to: Cognitive Effects of Deep Brain Stimulation inGBA‐Related Parkinson's Disease

Author

Pal, Gian, primary, Mangone, Graziella, additional, Ouyang, Bichun, additional, Ehrlich, Debra, additional, Saunders‐Pullman, Rachel, additional, Bressman, Susan, additional, Alcalay, Roy N., additional, Marder, Karen, additional, Aasly, Jan, additional, Mouradian, M. Maral, additional, Anderson, Sharlet, additional, Bernard, Bryan, additional, Stebbins, Glenn, additional, Sani, Sepehr, additional, Afshari, Mitra, additional, Verhagen, Leo, additional, de Bie, Rob M.A., additional, Foltynie, Tom, additional, Hall, Deborah, additional, Corvol, Jean‐Christophe, additional, and Goetz, Christopher G., additional

Published
2022
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12. Impact of the <scp>COVID</scp> ‐19 Pandemic on Parkinson's Disease and Movement Disorders

Author

Papa, Stella M., Brundin, Patrik, Fung, Victor S.C., Kang, Un Jung, Burn, David J., Colosimo, Carlo, Chiang, Han‐Lin, Alcalay, Roy N., Trenkwalder, Claudia, and Committee, and the MDS‐Scientific Issues

Subjects
2019-20 coronavirus outbreak, Movement disorders, Parkinson's disease, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Clinical Neurology, medicine.disease_cause, Article, Betacoronavirus, 03 medical and health sciences, Viewpoint, 0302 clinical medicine, Pandemic, Humans, Medicine, 030212 general & internal medicine, Pandemics, Coronavirus, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Movement Disorders, biology, SARS-CoV-2, business.industry, virus diseases, COVID-19, Parkinson Disease, biology.organism_classification, medicine.disease, Virology, Telemedicine, 3. Good health, Neurology, Neurology (clinical), medicine.symptom, Coronavirus Infections, business, 030217 neurology & neurosurgery
Abstract

Human coronaviruses have classically caused mild respiratory infections. Two previous outbreaks caused by newly identified coronaviruses, SARS‐CoV in 2002 and MERS‐CoV in 2012, caused serious respiratory disease with increased mortality. The current coronavirus disease 2019 (COVID‐19) pandemic is caused by SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2).The infection originated late 2019 in China, and in a few months disseminated to reach almost 200 countries, now affecting over 500,000 people with an overall estimated mortality of 4% (World Health Organization; March 27, 2020).

Published
2020

14. Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects inGBAMutation Carriers

Author

Pal, Gian, primary, Mangone, Graziella, additional, Hill, Emily J., additional, Ouyang, Bichun, additional, Liu, Yuanqing, additional, Lythe, Vanessa, additional, Ehrlich, Debra, additional, Saunders‐Pullman, Rachel, additional, Shanker, Vicki, additional, Bressman, Susan, additional, Alcalay, Roy N., additional, Garcia, Priscilla, additional, Marder, Karen S., additional, Aasly, Jan, additional, Mouradian, M. Maral, additional, Link, Samantha, additional, Rosenbaum, Marc, additional, Anderson, Sharlet, additional, Bernard, Bryan, additional, Wilson, Robert, additional, Stebbins, Glenn, additional, Nichols, William C., additional, Welter, Marie‐Laure, additional, Sani, Sepehr, additional, Afshari, Mitra, additional, Verhagen, Leo, additional, Bie, Rob M.A., additional, Foltynie, Tom, additional, Hall, Deborah, additional, Corvol, Jean‐Christophe, additional, and Goetz, Christopher G., additional

Published
2022
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18. Reply to “ PPP2R5D Genetic Mutations and Early Onset Parkinsonism”

Author

Kim, Christine Y., primary, Wirth, Thomas, additional, Hubsch, Cécile, additional, Németh, Andrea H., additional, Okur, Volkan, additional, Anheim, Mathieu, additional, Drouot, Nathalie, additional, Tranchant, Christine, additional, Rudolf, Gabrielle, additional, Chelly, Jamel, additional, Tatton‐Brown, Katrina, additional, Blauwendraat, Cornelis, additional, Vonsattel, Jean Paul G., additional, Cortes, Etty, additional, Alcalay, Roy N., additional, and Chung, Wendy K., additional

Published
2020
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19. Analysis of Heterozygous PRKN Variants and Copy‐Number Variations in Parkinson's Disease

Author

Yu, Eric, primary, Rudakou, Uladzislau, additional, Krohn, Lynne, additional, Mufti, Kheireddin, additional, Ruskey, Jennifer A., additional, Asayesh, Farnaz, additional, Estiar, Mehrdad A., additional, Spiegelman, Dan, additional, Surface, Matthew, additional, Fahn, Stanley, additional, Waters, Cheryl H., additional, Greenbaum, Lior, additional, Espay, Alberto J., additional, Dauvilliers, Yves, additional, Dupré, Nicolas, additional, Rouleau, Guy A., additional, Hassin‐Baer, Sharon, additional, Fon, Edward A., additional, Alcalay, Roy N., additional, and Gan‐Or, Ziv, additional

Published
2020
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20. Early‐Onset Parkinsonism Is a Manifestation of thePPP2R5Dp. E200K Mutation

Author

Kim, Christine Y., primary, Wirth, Thomas, additional, Hubsch, Cécile, additional, Németh, Andrea H., additional, Okur, Volkan, additional, Anheim, Mathieu, additional, Drouot, Nathalie, additional, Tranchant, Christine, additional, Rudolf, Gabrielle, additional, Chelly, Jamel, additional, Tatton‐Brown, Katrina, additional, Blauwendraat, Cornelis, additional, Vonsattel, Jean Paul G., additional, Cortes, Etty, additional, Alcalay, Roy N., additional, and Chung, Wendy K., additional

Published
2020
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21. Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine‐Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme‐Linked Immunosorbent Assay–Based Method

Author

Melachroinou, Katerina, primary, Kang, Min Suk, additional, Liong, Christopher, additional, Narayan, Sushma, additional, Levers, Najah, additional, Joshi, Neal, additional, Kopil, Katie, additional, Hutten, Samantha J., additional, Baptista, Marco A.S., additional, Padmanabhan, Shalini, additional, Kang, Un Jung, additional, Stefanis, Leonidas, additional, Alcalay, Roy N., additional, and Rideout, Hardy J., additional

Published
2020
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23. The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight

Author

Bandres-Ciga, Sara, Ahmed, Sarah, Gómez-Garre, Pilar, Kia, Demis A, Tan, Manuela, Houlden, Henry, Morris, Huw R, Plun-Favreau, Helene, Holmans, Peter, Hardy, John, Trabzuni, Daniah, Bras, Jose, PhD, John Quinn, Jesús, Silvia, Mok, Kin Y, Kinghorn, Kerri J, Billingsley, Kimberley, Wood, Nicholas W, Lewis, Patrick, Schreglmann, Sebastian, Guerreiro, Rita, Lovering, Ruth, R'Bibo, Lea, Manzoni, Claudia, Labrador-Espinosa, Miguel A, Rizig, Mie, Ryten, Mina, Guelfi, Sebastian, Escott-Price, Valentina, Chelban, Viorica, Foltynie, Thomas, Williams, Nigel, Morrison, Karen E, Brice, Alexis, Danjou, Fabrice, Macias, Daniel, Lesage, Suzanne, Corvol, Jean-Christophe, Martinez, Maria, Schulte, Claudia, Brockmann, Kathrin, Simón-Sánchez, Javier, Heutink, Peter, Rizzu, Patrizia, Sharma, Manu, Gasser, Thomas, Méndez-Del-Barrio, Carlota, Nicolas, Aude, Cookson, Mark R, Blauwendraat, Cornelis, Craig, David W, Faghri, Faraz, Gibbs, J Raphael, Hernandez, Dena G, Keuren-Jensen, Kendall Van, Shulman, Joshua M, Periñán-Tocino, Teresa, Iwaki, Hirotaka, Leonard, Hampton L, Nalls, Mike A, Robak, Laurie, Lubbe, Steven, Finkbeiner, Steven, Mencacci, Niccolo E, Lungu, Codrin, Singleton, Andrew B, Scholz, Sonja W, Tejera-Parrado, Cristina, Reed, Xylena, Alcalay, Roy N, Gan-Or, Ziv, Rouleau, Guy A, Krohn, Lynne, van Hilten, Jacobus J, Marinus, Johan, Adarmes-Gómez, Astrid D, Aguilar, Miquel, Alvarez, Ignacio, Vargas-González, Laura, Alvarez, Victoria, Barrero, Francisco Javier, Yarza, Jesús Alberto Bergareche, Bernal-Bernal, Inmaculada, Blazquez, Marta, Bonilla-Toribio, Marta, Botía, Juan A, Boungiorno, María Teresa, Buiza-Rueda, Dolores, Cámara, Ana, Diez-Fairen, Monica, Carrillo, Fátima, Carrión-Claro, Mario, Cerdan, Debora, Clarimón, Jordi, Compta, Yaroslau, de la Casa, Beatríz, Dols-Icardo, Oriol, Duarte, Jacinto, Duran, Raquel, Escamilla-Sevilla, Francisco, Ezquerra, Mario, Feliz, Cici, Fernández, Manel, Fernández-Santiago, Rubé, Garcia, Ciara, García-Ruiz, Pedro, Heredia, Maria Jose Gomez, Gonzalez-Aramburu, Isabel, Sabir, Marya S, Tartari, Juan Pablo, Pagola, Ana Gorostidi, Hoenicka, Janet, Infante, Jon, Jimenez-Escrig, Adriano, Kulisevsky, Jaime, Lopez-Sendon, Jose Luis, Arregui, Adolfo López de Munain, Buongiorno, Mariateresa, Torres, Irene Martínez, Marín, Juan, Marti, Maria Jose, Martínez-Castrillo, Juan Carlos, González, Manuel Menéndez, Mata, Marina, Mínguez, Adolfo, Mir, Pablo, Rezola, Elisabet Mondragon, Pagonabarraga, Javier, Pascual-Sedano, Berta, Pastor, Pau, Errazquin, Francisco Perez, Ruiz-Martínez, Javier, Ruz, Clara, Rodriguez, Antonio Sanchez, Sierra, María, Suarez-Sanmartin, Esther, Gorostidi, Ana, Tabernero, Cesar, Tolosa, Eduard, Valldeoriola, Francesc, Vela, Lydia, Vives, Francisco, Zimprich, Alexander, Pihlstrom, Lasse, Bergareche, Jesús Alberto, Toft, Mathias, Koks, Sulev, Taba, Pille, Hassin-Baer, Sharon, Dalgard, Clifton L, Adeleye, Adelani, Soltis, Anthony R, Alba, Camille, Viollet, Coralie, Bacikova, Dagmar, Mondragon, Elisabet, Hupalo, Daniel N, Sukumar, Gauthaman, Pollard, Harvey B, Wilkerson, Matthew D, Martinez, Elisa McGrath, Vinagre-Aragon, Ana, Croitoru, Ioana, Marín-Lahoz, Juan, Fernández-Santiago, Rubén, Muñoz, Esteban, Sanchez Rodriguez, Antonio, Menéndez-González, Manuel, Suarez-San Martin, Esther, Vela-Desojo, Lydia, Mínguez-Castellanos, Adolfo, Gomez Heredia, Maria Jose, Perez Errazquin, Francisco, Romero-Acebal, Manolo, Martínez Torres, Irene, Kim, Jonggeol Jeffrey, Center, American Genome, Brooks, Janet, Saez-Atienzar, Sara, Jorda, Rafael, Botia, Juan A, Bonet-Ponce, Luis, Clarke, Carl, Morris, Huw, Edsall, Connor, Hernandez, Dena, Simon Sanchez, Javier, Marti, Maria José, López de Munain, Adolfo, Singleton, Andrew, Consortium, International Parkinson Disease Genomics, Noyce, Alastair J, Kaiyrzhanov, Rauan, Middlehurst, Ben, National Institutes of Health (US), Department of Defense (US), Michael J. Fox Foundation for Parkinson's Research, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía, Sociedad Andaluza de Neurología, Jacques and Gloria Gossweiler Foundation, Fundación Alicia Koplowitz, Fundación Mutua Madrileña, and Universidad de Sevilla

Subjects
0301 basic medicine, Male, Multifactorial Inheritance, Parkinson's disease, age at onset, Machine Learning, 0302 clinical medicine, Cost of Illness, genetics [Parkinson Disease], Population specific, genetics [Genetic Predisposition to Disease], Age of Onset, genetics [Ubiquitin-Protein Ligases], Aged, 80 and over, Age at onset, Chromosome Mapping, Parkinson Disease, Middle Aged, Spanish population, humanities, Neurology, Christian ministry, Female, Adult, Genotype, Ubiquitin-Protein Ligases, Article, risk haplotype, 03 medical and health sciences, Risk score risk haplotype, Political science, polygenic risk score, Humans, Genetic Predisposition to Disease, ddc:610, Risk haplotype, Parkinson's disease, Spanish population, age at onset, polygenic risk score, risk haplotype, Aged, DNA Methylation, 030104 developmental biology, Haplotypes, Spain, Case-Control Studies, Polygenic risk score, Neurology (clinical), Polygenic, Humanities, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Background: The Iberian Peninsula stands out as having variable levels of population admixture and isolation, making Spain an interesting setting for studying the genetic architecture of neurodegenerative diseases. Objectives: To perform the largest PD genome-wide association study restricted to a single country. Methods: We performed a GWAS for both risk of PD and age at onset in 7,849 Spanish individuals. Further analyses included population-specific risk haplotype assessments, polygenic risk scoring through machine learning, Mendelian randomization of expression, and methylation data to gain insight into disease-associated loci, heritability estimates, genetic correlations, and burden analyses. Results: We identified a novel population-specific genome-wide association study signal at PARK2 associated with age at onset, which was likely dependent on the c.155delA mutation. We replicated four genome-wide independent signals associated with PD risk, including SNCA, LRRK2, KANSL1/MAPT, and HLA-DQB1. A significant trend for smaller risk haplotypes at known loci was found compared to similar studies of non-Spanish origin. Seventeen PD-related genes showed functional consequence by two-sample Mendelian randomization in expression and methylation data sets. Long runs of homozygosity at 28 known genes/loci were found to be enriched in cases versus controls. Conclusions: Our data demonstrate the utility of the Spanish risk haplotype substructure for future fine-mapping efforts, showing how leveraging unique and diverse population histories can benefit genetic studies of complex diseases. The present study points to PARK2 as a major hallmark of PD etiology in Spain., This research was supported, in part, by the Intramural Research Program of the National Institutes of Health (National Institute on Aging, National Institute of Neurological Disorders and Stroke; project numbers: 1ZIA‐NS003154‐03, Z01‐AG000949‐02, and Z01‐ES101986). In addition, this work was supported by the Department of Defense (award W81XWH‐09‐2‐0128), The Michael J Fox Foundation for Parkinson's Research, and the ISCIII Grants PI 15/0878 (Fondos Feder) to V.A. and PI 15/01013 to J,H. This study was supported by grants from the Spanish Ministry of Economy and Competitiveness (PI14/01823, PI16/01575, PI18/01898, [SAF2006‐10126 (2006‐2009), SAF2010‐22329‐C02‐01 (2010‐2012), and SAF2013‐47939‐R (2013‐2018)]), co‐founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía (CVI‐02526, CTS‐7685), the Consejería de Salud y Bienestar Social de la Junta de Andalucía (PI‐0437‐2012, PI‐0471‐2013), the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, and the Fundación Mutua Madrileña. Pilar Gómez‐Garre was supported by the “Miguel Servet” (from ISCIII16 FEDER) and “Nicolás Monardes” (from Andalusian Ministry of Health) programmes. Silvia Jesús Maestre was supported by the “Juan Rodés” programme, and Daniel Macías‐García was supported by the “Río Hortega” programme (both from ISCIII‐FEDER). Cristina Tejera Parrado was supported by VPPI‐US from the Universidad de Sevilla. This research has been conducted using samples from the HUVR‐IBiS Biobank (Andalusian Public Health System Biobank and ISCIII‐Red de Biobancos PT13/0010/0056). This work was also supported by the grant PSI2014‐57643 from the Junta de Andalucía to the CTS‐438 group and a research award from the Andalusian Society of Neurology.

Published
2019

24. Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies

Author

Krohn, Lynne, primary, Öztürk, Tuğba Nur, additional, Vanderperre, Benoît, additional, Ouled Amar Bencheikh, Bouchra, additional, Ruskey, Jennifer A., additional, Laurent, Sandra B., additional, Spiegelman, Dan, additional, Postuma, Ronald B., additional, Arnulf, Isabelle, additional, Hu, Michele T. M., additional, Dauvilliers, Yves, additional, Högl, Birgit, additional, Stefani, Ambra, additional, Monaca, Christelle Charley, additional, Plazzi, Giuseppe, additional, Antelmi, Elena, additional, Ferini‐Strambi, Luigi, additional, Heidbreder, Anna, additional, Rudakou, Uladzislau, additional, Cochen De Cock, Valérie, additional, Young, Peter, additional, Wolf, Pavlina, additional, Oliva, Petra, additional, Zhang, Xiaokui Kate, additional, Greenbaum, Lior, additional, Liong, Christopher, additional, Gagnon, Jean‐François, additional, Desautels, Alex, additional, Hassin‐Baer, Sharon, additional, Montplaisir, Jacques Y., additional, Dupré, Nicolas, additional, Rouleau, Guy A., additional, Fon, Edward A., additional, Trempe, Jean‐François, additional, Lamoureux, Guillaume, additional, Alcalay, Roy N., additional, and Gan‐Or, Ziv, additional

Published
2019
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27. Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls

Author

Agalliu, Ilir, primary, Ortega, Roberto A., additional, Luciano, Marta San, additional, Mirelman, Anat, additional, Pont‐Sunyer, Claustre, additional, Brockmann, Kathrin, additional, Vilas, Dolores, additional, Tolosa, Eduardo, additional, Berg, Daniela, additional, Warø, Bjørg, additional, Glickman, Amanda, additional, Raymond, Deborah, additional, Inzelberg, Rivka, additional, Ruiz‐Martinez, Javier, additional, Mondragon, Elisabet, additional, Friedman, Eitan, additional, Hassin‐Baer, Sharon, additional, Alcalay, Roy N., additional, Mejia‐Santana, Helen, additional, Aasly, Jan, additional, Foroud, Tatiana, additional, Marder, Karen, additional, Giladi, Nir, additional, Bressman, Susan, additional, and Saunders‐Pullman, Rachel, additional

Published
2019
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28. SMPD1 mutations, activity, and α‐synuclein accumulation in Parkinson's disease

Author

Alcalay, Roy N., primary, Mallett, Victoria, additional, Vanderperre, Benoît, additional, Tavassoly, Omid, additional, Dauvilliers, Yves, additional, Wu, Richard Y.J., additional, Ruskey, Jennifer A., additional, Leblond, Claire S., additional, Ambalavanan, Amirthagowri, additional, Laurent, Sandra B., additional, Spiegelman, Dan, additional, Dionne‐Laporte, Alexandre, additional, Liong, Christopher, additional, Levy, Oren A., additional, Fahn, Stanley, additional, Waters, Cheryl, additional, Kuo, Sheng‐Han, additional, Chung, Wendy K., additional, Ford, Blair, additional, Marder, Karen S., additional, Kang, Un Jung, additional, Hassin‐Baer, Sharon, additional, Greenbaum, Lior, additional, Trempe, Jean‐Francois, additional, Wolf, Pavlina, additional, Oliva, Petra, additional, Zhang, Xiaokui Kate, additional, Clark, Lorraine N., additional, Langlois, Melanie, additional, Dion, Patrick A., additional, Fon, Edward A., additional, Dupre, Nicolas, additional, Rouleau, Guy A., additional, and Gan‐Or, Ziv, additional

Published
2019
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33. Frequency of GBA Variants in Autopsy-proven Multiple System Atrophy

Author

Sklerov, Miriam, primary, Kang, Un J., additional, Liong, Christopher, additional, Clark, Lorraine, additional, Marder, Karen, additional, Pauciulo, Michael, additional, Nichols, William C., additional, Chung, Wendy K., additional, Honig, Lawrence S., additional, Cortes, Etty, additional, Vonsattel, Jean Paul, additional, and Alcalay, Roy N., additional

Published
2017
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34. Arm swing as a potential new prodromal marker of Parkinson's disease

Author

Mirelman, Anat, primary, Bernad‐Elazari, Hagar, additional, Thaler, Avner, additional, Giladi‐Yacobi, Eytan, additional, Gurevich, Tanya, additional, Gana‐Weisz, Mali, additional, Saunders‐Pullman, Rachel, additional, Raymond, Deborah, additional, Doan, Nancy, additional, Bressman, Susan B., additional, Marder, Karen S., additional, Alcalay, Roy N., additional, Rao, Ashwini K., additional, Berg, Daniela, additional, Brockmann, Kathrin, additional, Aasly, Jan, additional, Waro, Bjørg Johanne, additional, Tolosa, Eduardo, additional, Vilas, Dolores, additional, Pont‐Sunyer, Claustre, additional, Orr‐Urtreger, Avi, additional, Hausdorff, Jeffrey M., additional, and Giladi, Nir, additional

Published
2016
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35. The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort

Author

Kang, Un Jung, primary, Goldman, Jennifer G., additional, Alcalay, Roy N., additional, Xie, Tao, additional, Tuite, Paul, additional, Henchcliffe, Claire, additional, Hogarth, Penelope, additional, Amara, Amy W., additional, Frank, Samuel, additional, Rudolph, Alice, additional, Casaceli, Cynthia, additional, Andrews, Howard, additional, Gwinn, Katrina, additional, Sutherland, Margaret, additional, Kopil, Catherine, additional, Vincent, Lona, additional, and Frasier, Mark, additional

Published
2016
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36. Motor and Nonmotor Features of Carriers of the p.A53T Alpha‐Synuclein Mutation: A Longitudinal Study

Author

Papadimitriou, Dimitra, primary, Antonelou, Roubina, additional, Miligkos, Michael, additional, Maniati, Matina, additional, Papagiannakis, Nikolaos, additional, Bostantjopoulou, Sevasti, additional, Leonardos, Athannassios, additional, Koros, Christos, additional, Simitsi, Athina, additional, Papageorgiou, Sokratis G., additional, Kapaki, Elisabeth, additional, Alcalay, Roy N., additional, Papadimitriou, Alexandros, additional, Athanassiadou, Aglaia, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2016
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38. GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder

Author

Gan‐Or, Ziv, primary, Mirelman, Anat, additional, Postuma, Ronald B., additional, Arnulf, Isabelle, additional, Bar‐Shira, Anat, additional, Dauvilliers, Yves, additional, Desautels, Alex, additional, Gagnon, Jean‐François, additional, Leblond, Claire S., additional, Frauscher, Birgit, additional, Alcalay, Roy N., additional, Saunders‐Pullman, Rachel, additional, Bressman, Susan B., additional, Marder, Karen, additional, Monaca, Christelle, additional, Högl, Birgit, additional, Orr‐Urtreger, Avi, additional, Dion, Patrick A., additional, Montplaisir, Jacques Y., additional, Giladi, Nir, additional, and Rouleau, Guy A., additional

Published
2015
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40. The relationship between obsessive-compulsive symptoms andPARKINgenotype: The CORE-PD study

Author

Sharp, Madeleine E., primary, Caccappolo, Elise, additional, Mejia-Santana, Helen, additional, Tang, Ming-X., additional, Rosado, Llency, additional, Orbe Reilly, Martha, additional, Ruiz, Diana, additional, Louis, Elan D., additional, Comella, Cynthia, additional, Nance, Martha, additional, Bressman, Susan, additional, Scott, William K., additional, Tanner, Caroline, additional, Waters, Cheryl, additional, Fahn, Stanley, additional, Cote, Lucien, additional, Ford, Blair, additional, Rezak, Michael, additional, Novak, Kevin, additional, Friedman, Joseph H., additional, Pfeiffer, Ronald, additional, Payami, Haydeh, additional, Molho, Eric, additional, Factor, Stuart A., additional, Nutt, John, additional, Serrano, Carmen, additional, Arroyo, Maritza, additional, Pauciulo, Michael W., additional, Nichols, William C., additional, Clark, Lorraine N., additional, Alcalay, Roy N., additional, and Marder, Karen S., additional

Published
2014
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41. Interest in Genetic Testing in Ashkenazi Jewish Parkinson’s Disease Patients and Their Unaffected Relatives

Author

Gupte, Manisha, primary, Alcalay, Roy N., additional, Mejia-Santana, Helen, additional, Raymond, Deborah, additional, Saunders-Pullman, Rachel, additional, Roos, Ernest, additional, Orbe-Reily, Martha, additional, Tang, Ming-X, additional, Mirelman, Anat, additional, Ozelius, Laurie, additional, Orr-Urtreger, Avi, additional, Clark, Lorraine, additional, Giladi, Nir, additional, Bressman, Susan, additional, and Marder, Karen, additional

Published
2014
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43. Parkinson disease phenotype in Ashkenazi jews with and without LRRK2 G2019S mutations

Author

Alcalay, Roy N., primary, Mirelman, Anat, additional, Saunders‐Pullman, Rachel, additional, Tang, Ming‐X, additional, Mejia Santana, Helen, additional, Raymond, Deborah, additional, Roos, Ernest, additional, Orbe‐Reilly, Martha, additional, Gurevich, Tanya, additional, Bar Shira, Anat, additional, Gana Weisz, Mali, additional, Yasinovsky, Kira, additional, Zalis, Maayan, additional, Thaler, Avner, additional, Deik, Andres, additional, Barrett, Matthew James, additional, Cabassa, Jose, additional, Groves, Mark, additional, Hunt, Ann L., additional, Lubarr, Naomi, additional, San Luciano, Marta, additional, Miravite, Joan, additional, Palmese, Christina, additional, Sachdev, Rivka, additional, Sarva, Harini, additional, Severt, Lawrence, additional, Shanker, Vicki, additional, Swan, Matthew Carrington, additional, Soto‐Valencia, Jeannie, additional, Johannes, Brooke, additional, Ortega, Robert, additional, Fahn, Stanley, additional, Cote, Lucien, additional, Waters, Cheryl, additional, Mazzoni, Pietro, additional, Ford, Blair, additional, Louis, Elan, additional, Levy, Oren, additional, Rosado, Llency, additional, Ruiz, Diana, additional, Dorovski, Tsvyatko, additional, Pauciulo, Michael, additional, Nichols, William, additional, Orr‐Urtreger, Avi, additional, Ozelius, Laurie, additional, Clark, Lorraine, additional, Giladi, Nir, additional, Bressman, Susan, additional, and Marder, Karen S., additional

Published
2013
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49. Tremor severity and age: A cross-sectional, population-based study of 2,524 young and midlife normal adults

Author

Louis, Elan D., primary, Hafeman, Danella, additional, Parvez, Faruque, additional, Liu, Xinhua, additional, Alcalay, Roy N., additional, Islam, Tariqul, additional, Ahmed, Alauddin, additional, Siddique, Abu Bakar, additional, Patwary, Tazul Islam, additional, Melkonian, Stephanie, additional, Argos, Maria, additional, Levy, Diane, additional, and Ahsan, Habibul, additional

Published
2011
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