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Your search keyword '"Akihiro Goryu"' showing total 3 results
Start Over Author "Akihiro Goryu" Publisher wiley
3 results on '"Akihiro Goryu"'

1. Nanoscale‐tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo

Author

Rika Numano, Akihiro Goryu, Yoshihiro Kubota, Hirohito Sawahata, Shota Yamagiwa, Minako Matsuo, Tadahiro Iimura, Hajime Tei, Makoto Ishida, and Takeshi Kawano

Subjects
circadian rhythms, clock genes, ex vivo, nanoscale‐tipped wire, NTW array injection, short hairpin RNA, Biology (General), QH301-705.5
Abstract

Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too short (lengths of ~10 µm) to target neuronal cells in ~1‐mm‐thick brain tissues because the neuronal cells are located deep within the tissue. Here, we report the use of nanoscale‐tipped wire (NTW) arrays with diameters

Published
2022
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2. Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings

Author

Takeshi Kawano, Hirohito Sawahata, Hideo Oi, Yoshihiro Kubota, Makoto Ishida, Akihiro Goryu, Yoriko Ando, and Rika Numano

Subjects
Nanotube, Nanotubes, Materials science, Nanowires, business.industry, Nanowire, Action Potentials, 02 engineering and technology, General Chemistry, Signal-To-Noise Ratio, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Biomaterials, Electrode, Optoelectronics, General Materials Science, 0210 nano-technology, business, Electrodes, Nanoscopic scale, Intracellular, Biotechnology
Abstract

Intracellular recording nanoscale electrode devices provide the advantages of a high spatial resolution and high sensitivity. However, the length of nanowire/nanotube-based nanoelectrodes is currently limited to10 μm long due to fabrication issues for high-aspect-ratio nanoelectrodes. The concept reported here can address the technological limitations by fabricating100 μm long nanoscale-tipped electrodes, which show intracellular recording capability.

Published
2016
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3. Intracellular Electrodes: Nanoscale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings (Small 21/2016)

Author

Yoshihiro Kubota, Akihiro Goryu, Makoto Ishida, Yoriko Ando, Hirohito Sawahata, Hideo Oi, Rika Numano, and Takeshi Kawano

Subjects
Biomaterials, Materials science, Silicon, chemistry, Electrode, chemistry.chemical_element, General Materials Science, Nanotechnology, General Chemistry, Nanoscopic scale, Intracellular, Biotechnology
Published
2016
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