1. The potential of Quercetin to protect against loperamide‐induced constipation in rats
- Author
-
Wenhui Liu and Aimin Zhi
- Subjects
0301 basic medicine ,signal pathways ,Loperamide ,loperamide ,TRPV1 ,Substance P ,Pharmacology ,Motilin ,03 medical and health sciences ,symbols.namesake ,chemistry.chemical_compound ,0302 clinical medicine ,Glial cell line-derived neurotrophic factor ,medicine ,TX341-641 ,rat ,Original Research ,biology ,Nutrition. Foods and food supply ,constipation ,Interstitial cell of Cajal ,Nitric oxide synthase ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,symbols ,Quercetin ,Food Science ,medicine.drug - Abstract
Constipation is the most common gastrointestinal complaint all over the world, and it is a risk factor of colorectal cancer. In this study, the protective of Quercetin against loperamide‐induced constipation and its potential mechanism in a rat model were investigated. Results showed that Quercetin at 25 mg/kg and 50 mg/kg could significantly (p, Quercetin exerted a protective effect against loperamide‐induced constipation. The possible protective mechanisms of Quercetin might involve the innate immune response via modulating the c‐kit/SCF pathway and other pathways.
- Published
- 2021