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5 results on '"Adam Ioannou"'

1. Multiorgan Dysfunction and Associated Prognosis in Transthyretin Cardiac Amyloidosis

Author

Adam Ioannou, Christian Nitsche, Aldostefano Porcari, Rishi K. Patel, Yousuf Razvi, Muhammad U. Rauf, Ana Martinez‐Naharro, Lucia Venneri, Antonella Accietto, Lucrezia Netti, Francesco Bandera, Ruta Virsinskaite, Tushar Kotecha, Dan Knight, Aviva Petrie, Carol Whelan, Ashutosh Wechalekar, Helen Lachmann, Philip N. Hawkins, Julian D. Gillmore, and Marianna Fontana

Subjects
blood biomarkers, heart failure, mortality, transthyretin cardiac amyloidosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Transthyretin cardiac amyloidosis (ATTR‐CA) is a progressive and ultimately fatal cardiomyopathy. Biomarkers reflecting multiorgan dysfunction are of increasing importance in patients with heart failure; however, their significance in ATTR‐CA remains largely unknown. The aims of this study were to characterize the multifaceted nature of ATTR‐CA using blood biomarkers and assess the association between blood biomarkers and prognosis. Methods and Results This is a retrospective cohort study of 2566 consecutive patients diagnosed with ATTR‐CA between 2007 and 2023. Anemia (39%), high urea (52%), hyperbilirubinemia (18%), increased alkaline phosphatase (16%), increased CRP (C‐reactive protein; 27%), and increased troponin (98.2%) were common findings in the overall population, whereas hyponatremia (6%) and hypoalbuminemia (2%) were less common. These abnormalities were most common in patients with p.(V142I) hereditary ATTR‐CA, and became more prevalent as the severity of cardiac disease increased. Multivariable Cox regression analysis demonstrated that anemia (hazard ratio [HR], 1.19 [95% CI, 1.04–1.37]; P=0.01), high urea (HR, 1.23 [95% CI, 1.04–1.45]; P=0.01), hyperbilirubinemia (HR, 1.32 [95% CI, 1.13–1.57; P=0.001), increased alkaline phosphatase (HR, 1.20 [95% CI, 1.01–1.42; P=0.04), hyponatremia (HR, 1.65 [95% CI, 1.28–2.11]; P56 ng/L (HR, 1.72 [95% CI, 1.46–2.03]; P

Published
2024
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2. Sex differences among patients with transthyretin amyloid cardiomyopathy – from diagnosis to prognosis

Author

Rishi K. Patel, Adam Ioannou, Yousuf Razvi, Liza Chacko, Lucia Venneri, Francesco Bandera, Daniel Knight, Tushar Kotecha, Ana Martinez‐Naharro, Ambra Masi, Aldostefano Porcari, James Brown, Kiara Patel, Charlotte Manisty, James Moon, Dorota Rowczenio, Janet A. Gilbertson, Gianfranco Sinagra, Helen Lachmann, Ashutosh Wechalekar, Aviva Petrie, Carol Whelan, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana, Patel, Rishi K., Ioannou, Adam, Razvi, Yousuf, Chacko, Liza, Venneri, Lucia, Bandera, Francesco, Knight, Daniel, Kotecha, Tushar, Martinez-Naharro, Ana, Masi, Ambra, Porcari, Aldostefano, Brown, Jame, Patel, Kiara, Manisty, Charlotte, Moon, Jame, Rowczenio, Dorota, Gilbertson, Janet A., Sinagra, Gianfranco, Lachmann, Helen, Wechalekar, Ashutosh, Petrie, Aviva, Whelan, Carol, Hawkins, Philip N., Gillmore, Julian D., and Fontana, Marianna

Subjects
Male, Heart Failure, Amyloid Neuropathies, Familial, Sex Characteristics, diagnosis, Amyloidosis, Prognosis, echocardiography, sex, prognosis, diagnosi, Disease Progression, Amyloidosi, Humans, Prealbumin, Female, Cardiomyopathies, Cardiology and Cardiovascular Medicine
Abstract

Aims: transthyretin amyloid cardiomyopathy (ATTR-CM) is predominantly diagnosed in men. The few available studies suggest affected women have a more favourable cardiac phenotype. We aimed to characterize sex differences among consecutive patients with non-hereditary and two prevalent forms of hereditary (h)ATTR-CM diagnosed over a 20-year period. Methods and results: analysis of deep phenotyping at presentation, changes on serial echocardiography and overall prognosis were evaluated. In total, 1732 consecutive patients were studied, comprising: 1095 with wild-type (wt)ATTR-CM; 206 with T60A-hATTR-CM; and 431 with V122I-hATTR-CM. Female prevalence was greater in T60A-hATTR-CM (29.6%) and V122I-hATTR-CM (27.8%) compared to wtATTR-CM (6%). At presentation, females were 3.3 years older than males (wtATTR-CM: 81.9 vs. 77.8 years; T60A-hATTR-CM: 68.7 vs. 65.1 years; V122I-hATTR-CM: 77.1 vs. 74.9 years). Body size significantly influenced measures of disease severity; when indexed, overall structural and functional phenotype was similar between sexes, the few significant differences suggested a mildly worse phenotype in females. No significant differences were observed in both disease progression on serial echocardiography and mortality across the overall population (p = 0.459) and when divided by genotype (wtATTR-CM: p = 0.730; T60A-hATTR-CM: p = 0.161; V122I-hATTR-CM: p = 0.056). Conclusion: this study of a well-characterized large cohort of ATTR-CM patients did not demonstrate overall differences between sexes in either clinical phenotype, when indexed, or with respect to disease progression and prognosis. Non-indexed wall thickness measurements may have contributed to both under-representation and delays in diagnosis for affected females and highlights the potential role of utilizing indexed echocardiographic parameters for a more accurate assessment of patients at diagnosis and for disease prognostication.

Published
2022
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4. Coronary artery bypass surgery versus medical therapy alone for ischaemic heart disease

Author

Licheng Wang, Long Zuo, Xin Yue, Yiqun Cai, Linmiao Zeng, Linning Wang, Tao Bian, Adam Ioannou, Shaoke Li, and Hongmei He

Subjects
medicine.medical_specialty, business.industry, education, Mathematics::Algebraic Topology, Mathematics::Geometric Topology, Coronary artery bypass surgery, Text mining, Internal medicine, Computer Science::Networking and Internet Architecture, medicine, Cardiology, Ischaemic heart disease, Pharmacology (medical), business, Medical therapy, Computer Science::Cryptography and Security
Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of coronary artery bypass surgery versus medical therapy alone in people with ischaemic heart disease.

Published
2021
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5. External electrical and pharmacological cardioversion for atrial fibrillation, atrial flutter or atrial tachycardias: a network meta-analysis

Author

Adam Ioannou, Julie Taylor, Stephen B. Wilton, Pier D. Lambiase, Gillian Mead, Rui Providência, Immaculate If Nevis, Carlos A. Morillo, Nikolaos Papageorgiou, Kishore Kukendra-Rajah, and Derek S. Chew

Subjects
Medicine General & Introductory Medical Sciences, medicine.medical_specialty, business.industry, education, Atrial fibrillation, macromolecular substances, medicine.disease, Meta-analysis, Internal medicine, medicine, Cardiology, Pharmacological cardioversion, Pharmacology (medical), business, Atrial flutter
Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of pharmacological and electrical cardioversion for atrial fibrillation (AF).

Published
2019
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