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2. Glycolytic lactate production supports status epilepticus in experimental animals

Author

Daria Skwarzynska, Huayu Sun, Izabela Kasprzak, Supriya Sharma, John Williamson, and Jaideep Kapur

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Status epilepticus (SE) requires rapid intervention to prevent cerebral injury and mortality. The ketogenic diet, which bypasses glycolysis, is a promising remedy for patients with refractory SE. We tested the role of glycolytic lactate production in sustaining SE. Methods Extracellular lactate and glucose concentration during a seizure and SE in vivo was measured using lactate and glucose biosensors. A lactate dehydrogenase inhibitor, oxamate, blocked pyruvate to lactate conversion during SE. Video‐EEG recordings evaluated seizure duration, severity, and immunohistochemistry was used to determine neuronal loss. Genetically encoded calcium indicator GCaMP7 was used to study the effect of oxamate on CA1 pyramidal neurons in vitro. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded from CA1 neurons to study oxamate's impact on neurotransmission. Results The extracellular glucose concentration dropped rapidly during seizures, and lactate accumulated in the extracellular space. Inhibition of pyruvate to lactate conversion with oxamate terminated SE in mice. There was less neuronal loss in treated compared to control mice. Oxamate perfusion decreased tonic and phasic neuronal activity of GCaMP7‐expressing CA1 pyramidal neurons in vitro. Oxamate application reduced the frequency, but not amplitude of sEPSCs recorded from CA1 neurons, suggesting an effect on the presynaptic glutamatergic neurotransmission. Interpretation A single seizure and SE stimulate lactate production. Diminishing pyruvate to lactate conversion with oxamate terminated SE and reduced associated neuronal death. Oxamate reduced neuronal excitability and excitatory neurotransmission at the presynaptic terminal. Glycolytic lactate production sustains SE and is an attractive therapeutic target.

Published
2023
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3. High Resting Coronary Flow Velocity by Echocardiography Is Associated With Worse Survival in Patients With Chronic Coronary Syndromes

Author

Lauro Cortigiani, Nicola Gaibazzi, Quirino Ciampi, Fausto Rigo, Hugo Rodríguez‐Zanella, Karina Wierzbowska‐Drabik, Jaroslaw D. Kasprzak, Rosina Arbucci, Jorge Lowenstein, Angela Zagatina, Ylenia Bartolacelli, Dario Gregori, Scipione Carerj, Mauro Pepi, Patricia A. Pellikka, and Eugenio Picano

Subjects
coronary flow, diabetes, left anterior descending artery, vasodilatory stress, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Resting coronary flow velocity (CFV) in the mid‐distal left anterior descending coronary artery can be easily assessed with transthoracic echocardiography. In this observational study, the authors sought to assess the relationship between resting CFV, CFV reserve (CFVR), and outcome in patients with chronic coronary syndromes. Methods and Results In a prospective multicenter study design, the authors retrospectively analyzed 7576 patients (age, 66±11 years; 4312 men) with chronic coronary syndromes and left ventricular ejection fraction ≥50% referred for dipyridamole stress echocardiography. Recruitment (years 2003–2021) involved 7 accredited laboratories, with interobserver variability 2.0. Conclusions High resting CFV is associated with worse survival in patients with chronic coronary syndromes and left ventricular ejection fraction ≥50%. The value is independent and additive to CFVR. The combination of high resting CFV and low CFVR is associated with the worst survival.

Published
2024
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4. Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study)

Author

Jacek Kubica, Małgorzata Ostrowska, Wioleta Stolarek, Michał Kasprzak, Klaudyna Grzelakowska, Jacek Kryś, Aldona Kubica, Piotr Adamski, Przemysław Podhajski, Eliano Pio Navarese, Edyta Anielska‐Michalak, Oliwia Brycht, Andrzej Curzytek, Aneta Dudek, Leszek Gromadziński, Paweł Grzelakowski, Leszek Kamiński, Andrzej Kleinrok, Marcin Kostkiewicz, Marek Koziński, Paweł Król, Tomasz Kulawik, Gleb Minczew, Marcin Mindykowski, Agnieszka Pawlak, Janusz Prokopczuk, Grzegorz Skonieczny, Bożena Sobkowicz, Sergiusz Sowiński, Sebastian Stankala, Paweł Szymański, Andrzej Wester, Przemysław Wilczewski, Stanisław Bartuś, Andrzej Budaj, Mariusz Gąsior, Marcin Gruchała, Jarosław Drożdż, Miłosz Jaguszewski, Piotr Jankowski, Jacek Legutko, Maciej Lesiak, Przemysław Leszek, Przemysław Mitkowski, Jadwiga Nessler, Anna Tomaszuk‐Kazberuk, Agnieszka Tycińska, Tomasz Zdrojewski, and Jarosław Kaźmierczak

Subjects
Heart failure, COVID‐19, In‐hospital mortality, Hospitalization, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims The coronavirus disease‐2019 (COVID‐19) pandemic has changed the landscape of medical care delivery worldwide. We aimed to assess the influence of COVID‐19 pandemic on hospital admissions and in‐hospital mortality rate in patients with acute heart failure (AHF) in a retrospective, multicentre study. Methods and results From 1 January 2019 to 31 December 2020, a total of 101 433 patients were hospitalized in 24 Cardiology Departments in Poland. The number of patients admitted due to AHF decreased by 23.4% from 9853 in 2019 to 7546 in 2020 (P

Published
2022
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5. Gene expression profiling for metastatic risk in head and neck cutaneous squamous cell carcinoma

Author

Sarah T. Arron, Ashley Wysong, Mary A. Hall, Christine N. Bailey, Kyle R. Covington, Sarah J. Kurley, Matthew S. Goldberg, Julia M. Kasprzak, Ally‐Khan Somani, Sherrif F. Ibrahim, David G. Brodland, Nathan J. Cleaver, Ian A. Maher, Yang Xia, Shlomo A. Koyfman, and Jason G. Newman

Subjects
cutaneous squamous cell carcinoma (cSCC), gene expression profile (GEP), head and neck cSCC (cSCC‐HN), high‐risk cSCC, metastasis risk, Otorhinolaryngology, RF1-547, Surgery, RD1-811
Abstract

Abstract Objective Over 50% of newly diagnosed cutaneous squamous cell carcinoma (cSCC) lesions occur in the head and neck (cSCC‐HN), and metastasis to nodal basins in this region further complicates surgical and adjuvant treatment. The current study addressed whether the 40‐gene expression profile (40‐GEP) test can predict metastatic risk in cSCC‐HN with improved accuracy and provide independent prognostic value to complement current risk assessment methods. Study Design Multicenter, retrospective cohort study. Methods Formalin‐fixed paraffin‐embedded primary tumor tissue and associated clinical data from patients with cSCC‐HN (n = 278) were collected from 33 independent centers. Samples were analyzed via the 40‐GEP test. Cases were staged per American Joint Committee on Cancer, Eighth Edition (AJCC8) and Brigham and Women's Hospital (BWH) criteria after comprehensive medical record and pathology report review. Metastasis‐free survival (MFS) rates were determined, and risk factors were analyzed via Cox regression. Results The 40‐GEP test classified the cohort into low (Class 1, n = 126; 45.3%), moderate (Class 2A, n = 134; 48.2%), and high (Class 2B, n = 18; 6.5%) metastatic risk at 3 years postdiagnosis. Regional/distant metastasis occurred in 54 patients (19.4%). MFS rates were 92.1% (Class 1), 76.1% (Class 2A), and 44.4% (Class 2B; p

Published
2022
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9. Destructive Photon Echo Formation in Six‐Wave Mixing Signals of a MoSe2 Monolayer

Author

Thilo Hahn, Diana Vaclavkova, Miroslav Bartos, Karol Nogajewski, Marek Potemski, Kenji Watanabe, Takashi Taniguchi, Paweł Machnikowski, Tilmann Kuhn, Jacek Kasprzak, and Daniel Wigger

Subjects
nonlinear spectroscopy, photon echo, transition metal dichalcogenides, Science
Abstract

Abstract Monolayers of transition metal dichalcogenides display a strong excitonic optical response. Additionally encapsulating the monolayer with hexagonal boron nitride allows to reach the limit of a purely homogeneously broadened exciton system. On such a MoSe2‐based system, ultrafast six‐wave mixing spectroscopy is performed and a novel destructive photon echo effect is found. This process manifests as a characteristic depression of the nonlinear signal dynamics when scanning the delay between the applied laser pulses. By theoretically describing the process within a local field model, an excellent agreement with the experiment is reached. An effective Bloch vector representation is developed and thereby it is demonstrated that the destructive photon echo stems from a destructive interference of successive repetitions of the heterodyning experiment.

Published
2022
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15. Front Cover: Quantum Dot Molecule Devices with Optical Control of Charge Status and Electronic Control of Coupling (Adv. Quantum Technol. 10/2022)

Author

Bopp, Frederik, primary, Rojas, Jonathan, additional, Revenga, Natalia, additional, Riedl, Hubert, additional, Sbresny, Friedrich, additional, Boos, Katarina, additional, Simmet, Tobias, additional, Ahmadi, Arash, additional, Gershoni, David, additional, Kasprzak, Jacek, additional, Ludwig, Arne, additional, Reitzenstein, Stephan, additional, Wieck, Andreas, additional, Reuter, Dirk, additional, Müller, Kai, additional, and Finley, Jonathan J., additional

Published
2022
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16. Sex‐ and age‐related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long‐Term Registry

Author

Lainscak, M., Milinkovic, I., Polovina, M., Crespo-Leiro, M. G., Lund, L. H., Anker, S. D., Laroche, C., Ferrari, R., Coats, A. J. S., Mcdonagh, T., Filippatos, G., Maggioni, A. P., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Simic, D., Asanin, M., Eicher, J. -C., Yilmaz, M. B., Seferovic, P. M., Gale, C. P., Chair, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Mebazaa, A., Coats, A., A. Goda A. L., M. Diez A. R., A. Fernandez A. R., F. Fruhwald A. T., Fazlibegovic, E., P. Gatzov B. G., A. Kurlianskaya B. Y., R. Hullin C. H., T. Christodoulides C. Y., J. Hradec C. Z., O. Wendelboe Nielsen D. K., R. Nedjar D. Z., T. Uuetoa E. E., M. Hassanein E. G., J. F. Delgado Jimenez E. S., P. Harjola F. I., V, D. Logeart F. R., V. Chumburidze G. E., D. Tousoulis G. R., D. Milicic H. R., B. Merkely H. U., O'Donoghue IE, E., O. Amir I. L., A. Shotan I. L., D. Shafie I. R., M. Metra I. T., A. Matsumori J. P., E. Mirrakhimov K. G., A. Kavoliuniene L. T., A. Erglis L. V., Vataman, E., M. Otljanska M. K., E. Srbinovska Kostovska M. K., D. Cassar DeMarco M. T., J. Drozdz P. L., Fonseca, C., O. Chioncel R. O., M. Dekleva R. S., E. Shkolnik R. U., U. Dahlstrom S. E., M. Lainscak S. I., E. Goncalvesova S. K., A. Temizhan T. R., V. Estrago U. Y., G. Bajraktari X. K., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., J. -F., Ly, Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Genis, A. B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Gunes, H., Lainscak, M., Milinkovic, I., Polovina, M., Crespo-Leiro, M. G., Lund, L. H., Anker, S. D., Laroche, C., Ferrari, R., Coats, A. J. S., Mcdonagh, T., Filippatos, G., Maggioni, A. P., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Simic, D., Asanin, M., Eicher, J. -C., Yilmaz, M. B., Seferovic, P. M., Gale, C. P., Chair, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Mebazaa, A., Coats, A., A. Goda A., L., M. Diez A., R., A. Fernandez A., R., F. Fruhwald A., T., Fazlibegovic, E., P. Gatzov B., G., A. Kurlianskaya B., Y., R. Hullin C., H., T. Christodoulides C., Y., J. Hradec C., Z., O. Wendelboe Nielsen D., K., R. Nedjar D., Z., T. Uuetoa E., E., M. Hassanein E., G., J. F. Delgado Jimenez E., S., V-, P. Harjola F. I., D. Logeart F., R., V. Chumburidze G., E., D. Tousoulis G., R., D. Milicic H., R., B. Merkely H., U., O'Donoghue IE, E., O. Amir I., L., A. Shotan I., L., D. Shafie I., R., M. Metra I., T., A. Matsumori J., P., E. Mirrakhimov K., G., A. Kavoliuniene L., T., A. Erglis L., V., Vataman, E., M. Otljanska M., K., E. Srbinovska Kostovska M., K., D. Cassar DeMarco M., T., J. Drozdz P., L., Fonseca, C., O. Chioncel R., O., M. Dekleva R., S., E. Shkolnik R., U., U. Dahlstrom S., E., M. Lainscak S., I., E. Goncalvesova S., K., A. Temizhan T., R., V. Estrago U., Y., G. Bajraktari X., K., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., Ly, J. -F., Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Genis, A. B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Gunes, H., University of Zurich, and Seferović, Petar M

Subjects
Male, Registry, medicine.medical_specialty, Adverse outcomes, 610 Medicine & health, Angiotensin-Converting Enzyme Inhibitors, 030204 cardiovascular system & hematology, Independent predictor, 2705 Cardiology and Cardiovascular Medicine, Ventricular Function, Left, 03 medical and health sciences, Age, 0302 clinical medicine, Internal medicine, Age related, Hospitalization, Mortality, Sex, medicine, Humans, Registries, Medical prescription, Aged, Heart Failure, Ejection fraction, business.industry, Stroke Volume, medicine.disease, Ageing, Heart failure, 10209 Clinic for Cardiology, Female, Angiotensin Receptor Blockers, Cardiology and Cardiovascular Medicine, business
Abstract

[Abstract] Aims. This study aimed to assess age‐ and sex‐related differences in management and 1‐year risk for all‐cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results. Of 16 354 patients included in the European Society of Cardiology Heart Failure Long‐Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline‐directed medical therapy (GDMT) were high (angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, beta‐blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1‐year follow‐up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all‐cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all‐cause hospitalization (21.9% vs. 27.3%; P < 0.001) and there were no differences in causes of death. All‐cause mortality and all‐cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1‐year all‐cause mortality (restricted to patients with LVEF ≤45%). Mortality risk was significantly lower in patients of younger age, compared to patients aged >75 years. Conclusions. There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all‐cause mortality in patients with LVEF ≤45%.

Published
2019

17. Aquatic insect subsidies influence microbial composition and processing of detritus in near‐shore subarctic heathland

Author

David Hoekman, Randall D. Jackson, Matthew A. McCary, Jamieson C. Botsch, Claudio Gratton, and Madeline D. Kasprzak

Subjects
Shore, geography, Detritus, geography.geographical_feature_category, Ecology, Plant composition, Aquatic insect, Environmental science, Microbial composition, Decomposition, Subarctic climate, Ecology, Evolution, Behavior and Systematics
Published
2021

18. Electrochemical Recognition of Aromatic Species with Ferrocenylated 1,3,5‐Triazine‐ or 1,3,5‐Triphenylbenzene‐Containing Highly Organized Molecules

Author

Anna M. Nowicka, Monika K. Nisiewicz, Artur Kasprzak, and Aleksandra I. Kosińska

Subjects
Detection limit, 010405 organic chemistry, General Chemistry, 010402 general chemistry, Electrochemistry, Mass spectrometry, 01 natural sciences, Toluene, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, 1,3,5-Triazine, Yield (chemistry), Molecule, Structural analog
Abstract

Two ferrocenylated organized molecules comprising 1,3,5-triphenylbenzene (Fc-1) or 2,4,6-triphenyl-1,3,5-triazine skeletons (Fc-2) were used for the first time as receptor layers for the electrochemical recognition of polycyclic aromatic hydrocarbons. While our group recently reported the synthesis of Fc-1, herein the facile synthesis of its 2,4,6-triphenyl-1,3,5-triazine-containing structural analog (Fc-2) is presented. Although the synthesis of Fc-2 was found to be challenging, we achieved a very high yield (89 %) under mild conditions using an acid-catalyzed imine-bond formation reaction in 1,4-dioxane:toluene solvent system. Title compounds were comprehensively characterized with various analytical techniques, including spectroscopic (NMR, FT-IR, FT-Raman spectroscopy) methods, high-resolution mass spectrometry (HRMS), microscopic (SEM) and electrochemical (CV) analyses. Fc-1 and Fc-2 were also used for the construction of the first-of-a-kind recognition layers (electrochemical sensors) dedicated to the recognition of polycyclic aromatic hydrocarbons. Fully constructed innovative sensors enabled the efficient recognition of analytes since the limit of detection (LOD) values were not higher than 2.9 μM. Comparative studies between the working parameters of electrochemical sensors comprising Fc-1 or Fc-2 were also included in this work.

Published
2021

19. Transthoracic echocardiography for arrhythmic mitral valve prolapse: Phenotypic characterization as first step

Author

Vriz, Olga, primary, Eltayeb, Abdulla, additional, Landi, Irene, additional, Anwar, Kashif, additional, Alenazy, Ali, additional, Hiristova, Krassimira, additional, Kasprzak, Jarek, additional, D'Andrea, Antonello, additional, Amro, Bandar, additional, Limongelli, Giuseppe, additional, Bossone, Eduardo, additional, and Imazio, Massimo, additional

Published
2022
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20. Quantum Dot Molecule Devices with Optical Control of Charge Status and Electronic Control of Coupling

Author

Bopp, Frederik, primary, Rojas, Jonathan, additional, Revenga, Natalia, additional, Riedl, Hubert, additional, Sbresny, Friedrich, additional, Boos, Katarina, additional, Simmet, Tobias, additional, Ahmadi, Arash, additional, Gershoni, David, additional, Kasprzak, Jacek, additional, Ludwig, Arne, additional, Reitzenstein, Stephan, additional, Wieck, Andreas, additional, Reuter, Dirk, additional, Müller, Kai, additional, and Finley, Jonathan J., additional

Published
2022
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21. Temperature as an Extra Dimension in Multidimensional Protein NMR Spectroscopy

Author

Borja Mateos, Paweł Małecki, Robert Konrat, Clara Conrad-Billroth, Krzysztof Kazimierczuk, Alexandra Shchukina, Mateusz Urbańczyk, Georg Kontaxis, Paweł Kasprzak, and Michał Nowakowski

Subjects
Signal processing, Radon transform, 010405 organic chemistry, Chemistry, Protein dynamics, Organic Chemistry, Temperature, Proteins, General Chemistry, Nuclear magnetic resonance spectroscopy, 010402 general chemistry, Intrinsically disordered proteins, 01 natural sciences, Measure (mathematics), Catalysis, 0104 chemical sciences, Compressed sensing, Sensitivity (control systems), Biological system, Nuclear Magnetic Resonance, Biomolecular
Abstract

NMR spectroscopy is a particularly informative method for studying protein structures and dynamics in solution; however, it is also one of the most time-consuming. Modern approaches to biomolecular NMR spectroscopy are based on lengthy multidimensional experiments, the duration of which grows exponentially with the number of dimensions. The experimental time may even be several days in the case of 3D and 4D spectra. Moreover, the experiment often has to be repeated under several different conditions, for example, to measure the temperature-dependent effects in a spectrum (temperature coefficients (TCs)). Herein, a new approach that involves joint sampling of indirect evolution times and temperature is proposed. This allows TCs to be measured through 3D spectra in even less time than that needed to acquire a single spectrum by using the conventional approach. Two signal processing methods that are complementary, in terms of sensitivity and resolution, 1) dividing data into overlapping subsets followed by compressed sensing reconstruction, and 2) treating the complete data set with a variant of the Radon transform, are proposed. The temperature-swept 3D HNCO spectra of two intrinsically disordered proteins, osteopontin and CD44 cytoplasmic tail, show that this new approach makes it possible to determine TCs and their non-linearities effectively. Non-linearities, which indicate the presence of a compact state, are particularly interesting. The complete package of data acquisition and processing software for this new approach are provided.

Published
2020

22. Spinal dural leaks in patients with infratentorial superficial siderosis of the central nervous system—Refinement of a diagnostic algorithm

Author

Helmuth Steinmetz, Beata Rezny-Kasprzak, Richard du Mesnil de Rochemont, Christian Foerch, and Lucie Friedauer

Subjects
Central Nervous System, Siderosis, Subarachnoid hemorrhage, Hemosiderosis, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, medicine, Humans, 030212 general & internal medicine, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Subarachnoid Hemorrhage, medicine.disease, Magnetic Resonance Imaging, Superficial siderosis, Venous thrombosis, medicine.anatomical_structure, Neurology, Neurology (clinical), Subarachnoid space, business, Algorithm, Algorithms, 030217 neurology & neurosurgery
Abstract

Background and purpose Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric infratentorial siderosis pattern. Methods In all, 97,733 magnetic resonance images performed between 2007 and 2018 in our neurocenter were screened by a keyword search for "hemosiderosis" and "superficial siderosis." Siderosis patterns on brain imaging were classified according to a previously published algorithm. Potential causative intracranial bleeding events were also assessed. Patients with a symmetric infratentorial siderosis pattern but without causative intracranial bleeding events in history were prospectively evaluated for spinal pathologies. Results Forty-two patients with isolated supratentorial siderosis, 30 with symmetric infratentorial siderosis and 21 with limited (non-symmetric) infratentorial siderosis were identified. Amyloid angiopathy and subarachnoid hemorrhage were causes for isolated supratentorial siderosis. In all four patients with a symmetric infratentorial siderosis pattern but without a causative intracranial bleeding event in history, spinal dural abnormalities were detected. Dural leaks were searched for in patients with symmetric infratentorial siderosis and a history of intracranial bleeding event without known bleeding etiology, considering that spinal dural CSF leaks themselves may also cause intracranial hemorrhage, for example by inducing venous thrombosis due to low CSF pressure. Thereby, one additional spinal dural leak was detected. Conclusions Persisting spinal dural CSF leaks can frequently be identified in patients with a symmetric infratentorial siderosis pattern. Diagnostic workup in these cases should include magnetic resonance imaging of the whole spine.

Published
2020

23. Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function

Author

Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Paweł Chudoba, Oktawia Mazanowska, Mirosław Banasik, Marcelina Żabinska, Maria Boratyńska, Agnieszka Lepiesza, Agnieszka Gomółkiewicz, Piotr Dzięgiel, and Marian Klinger

Subjects
Pathology, RB1-214
Abstract

Renal transplant candidates present immune dysregulation, caused by chronic uremia. The aim of the study was to investigate whether pretransplant peripheral blood gene expression of immune factors affects clinical outcome of renal allograft recipients. Methods. In a prospective study, we analyzed pretransplant peripheral blood gene expression in87 renal transplant candidates with real-time PCR on custom-designed low density arrays (TaqMan). Results. Immediate posttransplant graft function (14-day GFR) was influenced negatively by TGFB1 (P=0.039) and positively by IL-2 gene expression (P=0.040). Pretransplant blood mRNA expression of apoptosis-related genes (CASP3, FAS, and IL-18) and Th1-derived cytokine gene IFNG correlated positively with short- (6-month GFR CASP3: P=0.027, FAS: P=0.021, and IFNG: P=0.029) and long-term graft function (24-month GFR CASP3: P=0.003, FAS: P=0.033, IL-18: P=0.044, and IFNG: P=0.04). Conclusion. Lowered pretransplant Th1-derived cytokine and apoptosis-related gene expressions were a hallmark of subsequent worse kidney function but not of acute rejection rate. The pretransplant IFNG and CASP3 and FAS and IL-18 genes’ expression in the recipients’ peripheral blood is the possible candidate for novel biomarker of short- and long-term allograft function.

Published
2016
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24. CD3+CD8+CD28− T Lymphocytes in Patients with Lupus Nephritis

Author

Marcelina Żabińska, Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, and Marian Klinger

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

The results of studies on the CD3+CD8+CD28- cells in SLE are inconsistent since several analyses describe CD3+CD8+CD28- as either immunosuppressive or cytotoxic. The aim of this study is to inquire whether the quantitative changes of CD3+CD8+CD28- T lymphocytes subpopulation are related to the clinical status of patients with lupus nephritis. Evaluation of Foxp3 expression on CD3+CD8+CD28- cells may shed some light on functional properties of these cells. 54 adult SLE patients and 19 sex and age matched healthy volunteers were enrolled in the study. There were 15 patients in inactive (SLEDAI ≤ 5) and 39 in active (SLEDAI > 5) phase of disease. We determined absolute count of CD3+CD8+CD28- and CD3+CD8+CD28-Foxp3+ subpopulations by flow cytometry. We observed a statistically significant increase in absolute count and percentage of CD3+CD8+CD28- in SLE patients compared to HC (p

Published
2016
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26. Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

Author

Jackson, Alice M., Petrie, Mark C., Frogoudaki, Alexandra, Laroche, Cécile, Gustafsson, Finn, Ibrahim, Bassem, Mebazaa, Alexandre, Johnson, Mark R., Seferovic, Petar M., Regitz‐Zagrosek, Vera, Mbakwem, Amam, Böhm, Michael, Prameswari, Hawani Sasmaya, Abdel Gawad, Doaa Ahmed Fouad, Goland, Sorel, Damasceno, Albertino, Karaye, Kamilu, Farhan, Hasan Ali, Hamdan, Righab, Maggioni, Aldo P., Sliwa, Karen, Bauersachs, Johann, Meer, Peter, Favaloro, R., Favaloro, L., Carballo, M., Peradejordi, M., Renedo, M.F., Absi, D., Bertolotti, A., Ratto, R., Talavera, M.L., Gomez, R., Lockwood, S., Barton, T., Austin, M‐A., Arstall, M., Aldridge, E., Chow, Y.Y., Dekker, G., Mahadavan, G., Rose, J., Wittwer, M., Hoppe, U., Sandhofer, A., Bahshaliyev, A., Gasimov, Z., Babayev, A., Niftiyev, P., Hasanova, I., AlBannay, R., AlHaiki, W., Husain, A., Mahdi, N., Kurlianskaya, A., Lukyanchyk, M., Shatova, O., Troyanova‐Shchutskaia, T., Anghel, L., De Pauw, M., Gevaert, S., De Backer, J., De Hosson, M., Vervaet, P., Timmermans, P.J., Janssen, A., Yameogo, N.V., Kagambega, L.J., Cumyn, A., Caron, N., Cote, A‐M., Sauve, N., Nkulu, D. Ngoy, Lez, D. Malamba, Yolola, E. Ngoy, Krejci, J., Poloczkova, H., Ersboll, A., Gustafsson, F., Elrakshy, Y., Hassanein, M., Hammad, B., Eldin, O. Nour, Fouad, D., Salman, S., Zareh, Z., Abdeall, D., Elenin, H. Abo, Ebaid, H., El Nagar, A., Farag, S., Saed, M., El Rahman, Y H Abd, Ibrahim, B.S., Abdelhamid, M., Hanna, R.N. W., Youssef, G., Awad, R., Botrous, O.L. I., Halawa, S. Ibrahim, Nasr, G., Saad, A., El Tahlawi, M., Abdelbaset, M., El‐saadawy, M., El‐shorbagy, A., Shalaby, G., Anttonen, O., Tolppanen, H., Hamekoski, S., Menez, T., Noel, A., Lamblin, N., Mouquet, F., Coulon, C., Groote, P., Langlois, S., Schurtz, G., Cohen‐Solal, A., Mebazaa, A., Fournier, M‐C., Louadah, B., Akrout, N., Logeart, D., Leurent, G., Jovanova, S., Arnaudova‐Dezulovicj, F., Livrinova, V., Bauersachs, J., Hilfiker‐Kleiner, D., Berliner, D., Jungesblut, M., Koenig, T., Moulig, V.A., Pfeffer, T.J., Böhm, M., Kindermann, I., Schwarz, V., Schmitt, C., Swojanowsky, P., Pettit, S., Petrie, M., McAdam, M., Patton, D., Bakhai, A., Krishnamurthy, V., Lim, L., Clifford, P., Bowers, N., Clark, A. L., Witte, K., Cullington, D., Oliver, J., Simms, A., Mcginlay, M., McDonagh, T., Shah, A. M., Amin‐Youssef, G., De Courcey, J., Martin, K., Shaw, S., Vause, S., Wallace, S., Malin, G., Wick, C., Nikolaou, M., Rentoukas, I., Chinchilla, H., Andino, L., Iyengar, S., Chandra, S., Yadav, D.K., Babu, R. Ravi, Singh, A.K., Kumar, S., Karunamay, B.B., Chaubey, S.K., Dhiman, S.R., Jha, V.C., Singh, S.K., Kodati, D., Dasari, R., Sultana, S., Dewi, T.I., Prameswari, H. Sasmaya, Al‐Farhan, H.A., Al‐Hussein, A., Yaseen, I.F., Al‐Azzawi, Falah, Al‐Saedi, Ghazi, Mahmood, G.M., Mohammed, M.K., Ridha, A.F., Shotan, A., Vazan, A., Goland, S., Biener, M., Senni, M., Grosu, A., Martin, E., Esposti, D. Degli, Bacchelli, S., Borghi, C., Metra, M., Sciatti, E., Orabona, R., Sani, F., Brunetti, N.D., Sinagra, G., Bobbo, M., D'Agata Mottolese, B., Gesuete, V., Rakar, S., Ramani, F., Kamiya, C., Barasa, A., Ngunga, M., Bajraktari, G., Hyseni, V., Lleshi, D., Pllana, E., Pllana, T., Noruzbaeva, A., Ismailov, F., Mirrakhimov, E., Abilova, S., Lunegova, O., Kerimkulova, A., Osmankulova, G., Duishenalieva, M., Kurmanbekova, B., Turgunov, M., Mamasaidova, S., Bektasheva, E., Kavoliuniene, A., Muckiene, G., Vaitiekiene, A., Celutkiene, J., Balkevicine, L., Barysiene, J., Chee, K.H., Damasceno, A., Machava, M., Veldhuisen, D.J., Meer, P., Berg, M., Roos‐Hesselink, J., Hagen, I., Baris, L., Hurtado, P., Ezeonu, P., Isiguzo, G., Obeka, N., Onoh, R., Asogwa, F., Onyema, C., Otti, K., Ojji, D., Odili, A., Nwankwo, A., Karaye, K., Ishaq, N., Sanni, B., Abubakar, H., Mohammed, B., Sani, M., Kehinde, M., Mbakwem, A., Afolabi, B., Amadi, C., Kilasho, M., Qamar, N., Furnaz, S., Gurmani, S., Kayani, M.G.A. Mahmood, Munir, R., Hussain, S., Malik, S., Mumtaz, S., Saligan, J.R., Rubis, P., Biernacka‐Fijalkowska, B., Lesniak‐Sobelga, A., Wisniowska‐Smialek, S., Kasprzak, J.D., Lelonek, M., Zycinski, P., Jankowski, L., Grajek, S., Oko‐Sarnowska, Z., Rutkowska, A. Bartczak, Kaluzna‐Oleksy, M., Plaskota, K., Demkow, M., Dzielinska, Z., Henzel, J., Kryczka, K., Moiseeva, O., Irtyuga, O., Karelkina, E., Zazerskaya, I., Seferovic, P.M., Milinkovic, I., Živkovic, I., Ristic, A.D., Milasinovic, D., Kong, W. KF, Tan, L.K., Tan, J.L., Thain, S., Poh, K.K., Yip, J., Sliwa, K., Azibani, F., Hovelmann, J., Viljoen, C., Briton, O., Zamora, E., Orcajo, N. Alonso, Carbonell, R., Pascual, C., Muncharaz, J. Farre, Alonso‐Pulpon, L., Cubero, J. Segovia, Urquia, M. Taibo, Garcia‐Pavia, P., Gomez‐Bueno, M., Cobo‐Marcos, M., Briceno, A., Galvan, E. De Teresa, Garcia‐Pinilla, J.M., Robles‐Mezcua, A., Morcillo‐Hildalgo, L., Elbushi, A., Suliman, A., Ahamed, N., Jazzar, K., Murtada, M., Schaufelberger, M., Goloskokova, V., Hullin, R., Yarol, N., Arrigo, M., Cavusoglu, Y., Eraslan, S., Fak, A.S., Enar, S. Catirli, Sarac, L., Cankurtaran, B., Gumrukcuoglu, H., Ozturk, F., Omagino, J., Mondo, C., Lwabi, P., Ingabire, P., Nabbaale, J., Nyakoojo, W., Okello, E., Sebatta, E., Ssinabulya, I., Atukunda, E., Kitooleko, S., Semu, T., Salih, B.T., Komaranchath, A.M., Almahmeed, W.A.R., Gerges, F., Farook, F.S. Mohamed, Albakshy, F., Mahmood, N., Wani, S., Freudenberger, R., Islam, N., Quinones, J., Sundlof, D., Beitler, C., Centolanza, L., Cornell, K., Huffaker, S., Matos, L., Marzo, K., Paruchuri, V., Patel, D., Abdullaev, T., Alyavi, B., Mirzarakhimova, S., Tsoy, I., Bekbulatova, R., and Uzokov, J.

Abstract

Aims: \ud Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy.\ud \ud Methods: \ud The European Society of Cardiology PPCM Registry enrolled women with PPCM from 2012-2018. Three groups were examined: 1) women without hypertension (‘PPCM-noHTN’); 2) women with hypertension but without pre-eclampsia (‘PPCM-HTN’); 3) women with pre-eclampsia (‘PPCM-PE’). Maternal (6-month) and neonatal outcomes were compared.\ud \ud Results: \ud Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (NYHA IV in 44.4% and 29.9%, p

Published
2021

28. Gene expression profiling for metastatic risk in head and neck cutaneous squamous cell carcinoma

Author

Arron, Sarah T., primary, Wysong, Ashley, additional, Hall, Mary A., additional, Bailey, Christine N., additional, Covington, Kyle R., additional, Kurley, Sarah J., additional, Goldberg, Matthew S., additional, Kasprzak, Julia M., additional, Somani, Ally‐Khan, additional, Ibrahim, Sherrif F., additional, Brodland, David G., additional, Cleaver, Nathan J., additional, Maher, Ian A., additional, Xia, Yang, additional, Koyfman, Shlomo A., additional, and Newman, Jason G., additional

Published
2022
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29. Front Cover: Quantum Dot Molecule Devices with Optical Control of Charge Status and Electronic Control of Coupling (Adv. Quantum Technol. 10/2022)

Author

Frederik Bopp, Jonathan Rojas, Natalia Revenga, Hubert Riedl, Friedrich Sbresny, Katarina Boos, Tobias Simmet, Arash Ahmadi, David Gershoni, Jacek Kasprzak, Arne Ludwig, Stephan Reitzenstein, Andreas Wieck, Dirk Reuter, Kai Müller, and Jonathan J. Finley

Subjects
Nuclear and High Energy Physics, Computational Theory and Mathematics, Statistical and Nonlinear Physics, Electrical and Electronic Engineering, Condensed Matter Physics, Mathematical Physics, Electronic, Optical and Magnetic Materials
Published
2022

30. Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study)

Author

Kubica, Jacek, primary, Ostrowska, Małgorzata, additional, Stolarek, Wioleta, additional, Kasprzak, Michał, additional, Grzelakowska, Klaudyna, additional, Kryś, Jacek, additional, Kubica, Aldona, additional, Adamski, Piotr, additional, Podhajski, Przemysław, additional, Navarese, Eliano Pio, additional, Anielska‐Michalak, Edyta, additional, Brycht, Oliwia, additional, Curzytek, Andrzej, additional, Dudek, Aneta, additional, Gromadziński, Leszek, additional, Grzelakowski, Paweł, additional, Kamiński, Leszek, additional, Kleinrok, Andrzej, additional, Kostkiewicz, Marcin, additional, Koziński, Marek, additional, Król, Paweł, additional, Kulawik, Tomasz, additional, Minczew, Gleb, additional, Mindykowski, Marcin, additional, Pawlak, Agnieszka, additional, Prokopczuk, Janusz, additional, Skonieczny, Grzegorz, additional, Sobkowicz, Bożena, additional, Sowiński, Sergiusz, additional, Stankala, Sebastian, additional, Szymański, Paweł, additional, Wester, Andrzej, additional, Wilczewski, Przemysław, additional, Bartuś, Stanisław, additional, Budaj, Andrzej, additional, Gąsior, Mariusz, additional, Gruchała, Marcin, additional, Drożdż, Jarosław, additional, Jaguszewski, Miłosz, additional, Jankowski, Piotr, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Leszek, Przemysław, additional, Mitkowski, Przemysław, additional, Nessler, Jadwiga, additional, Tomaszuk‐Kazberuk, Anna, additional, Tycińska, Agnieszka, additional, Zdrojewski, Tomasz, additional, and Kaźmierczak, Jarosław, additional

Published
2021
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32. Fe 3+ reduction during melt‐synthesis of LiFePO 4

Author

Guoxian Liang, Pierre Sauriol, Delin Li, Mickaël Dollé, Patrice Chartrand, Gregory S. Patience, Bahman Yari, Lida Hadidi, Liling Jin, Michel Gauthier, Hernando Villazon, and Wojciech Kasprzak

Subjects
Reduction (complexity), Materials science, Chemical engineering, General Chemical Engineering, 0211 other engineering and technologies, 02 engineering and technology, 021001 nanoscience & nanotechnology, 0210 nano-technology, 021102 mining & metallurgy
Published
2019

33. Piloting melt synthesis and manufacturing processes to produce c‐lifepo 4 : preface

Author

Gregory S. Patience, Guoxian Liang, Xueliang Sun, Pierre Sauriol, Patrice Chartrand, Jamal Chaouki, Mohammad Latifi, Mickaël Dollé, Tsun-Kong Sham, and Wojciech Kasprzak

Subjects
chemistry.chemical_compound, Materials science, chemistry, Chemical engineering, General Chemical Engineering, Lithium iron phosphate, 02 engineering and technology, Comminution, 010402 general chemistry, 021001 nanoscience & nanotechnology, 0210 nano-technology, 01 natural sciences, 0104 chemical sciences
Published
2019

35. Chemical and enzymatic stability of the oleanoyl oxime ibuprofenate

Author

Izabela Muszalska, Katarzyna Sowa-Kasprzak, Dorota Olender, Katarzyna Becla, Monika A. Lesniewska-Kowiel, Wojciech Duda, and Anna Pawełczyk

Subjects
Inorganic Chemistry, chemistry.chemical_classification, chemistry.chemical_compound, Enzyme, chemistry, Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Oxime, Biochemistry, Oleanolic acid
Published
2019

38. Imaging the right heart pulmonary circulation unit: Insights from advanced ultrasound techniques

Author

Alberto M. Marra, Francesco Ferrara, Michele D'Alto, Antonello D'Andrea, Paola Argiento, Anna Agnese Stanziola, Christine Selton-Suty, Damien Voilliot, Luna Gargani, Jarosław D. Kasprzak, Olga Vriz, Ellen Ostenfeld, Antonio Cittadini, Eduardo Bossone, Ferrara, Francesco, Gargani, Luna, Ostenfeld, Ellen, D'Alto, Michele, Kasprzak, Jaroslaw, Voilliot, Damien, Selton-Suty, Christine, Vriz, Olga, Marra, Alberto M., Argiento, Paola, Stanziola, Anna A., Cittadini, Antonio, D'Andrea, Antonello, and Bossone, Eduardo

Subjects
Pulmonary Circulation, medicine.medical_specialty, Heart Ventricles, Hypertension, Pulmonary, stress echocardiography, Echocardiography, Three-Dimensional, Hemodynamics, 030204 cardiovascular system & hematology, Doppler echocardiography, 03 medical and health sciences, strain, 0302 clinical medicine, Nuclear Medicine and Imaging, Internal medicine, three-dimensional echocardiography, medicine, Stress Echocardiography, Humans, echocardiography, lung ultrasound, right heart pulmonary circulation unit, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, E/A ratio, medicine.diagnostic_test, business.industry, Ultrasound, Gold standard, Coronary flow reserve, medicine.disease, Pulmonary hypertension, Echocardiography, Doppler, Ventricular Function, Right, Cardiology, Radiology, business
Abstract

The right heart pulmonary circulation unit (RH-PCU) is a key determinant of prognosis in several cardiorespiratory diseases. Although right heart catheterization is considered the gold standard for pulmonary hemodynamic assessment, a comprehensive cardiovascular ultrasound approach is an essential step in the diagnostic-prognostic clinical pathway of patients with suspect or overt pulmonary hypertension. The exponential development of advanced ultrasound techniques (strain, 3-dimensional echocardiography and lung ultrasound) has led to new insights into the evaluation of RH-PCU structure and function, overcoming some limitations of standard Doppler echocardiography. In the near future, exercise Doppler echocardiography may become a useful technique for detecting a latent stage of pulmonary hypertension and for evaluating right ventricular contractile reserve.

Published
2017

39. Folic Acid-Navigated and β-Cyclodextrin-Decorated Carbon-Encapsulated Iron Nanoparticles as the Nanotheranostic Platform for Controlled Release of 5-Fluorouracil

Author

Magdalena Poplawska, Katarzyna Gunka, Artur Kasprzak, Maciej Fronczak, and Michał Bystrzejewski

Subjects
chemistry.chemical_classification, Cyclodextrin, Graphene, chemistry.chemical_element, Nanoparticle, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Controlled release, 0104 chemical sciences, law.invention, chemistry, Folic acid, Fluorouracil, law, Drug delivery, medicine, 0210 nano-technology, Carbon, Nuclear chemistry, medicine.drug
Published
2018

40. Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation

Author

Axel Bauer, Jarosław D. Kasprzak, Rajeeva Sritharan, Nikola Pavlović, Tomas Novotny, Panagiota Flevari, Jesper Hastrup Svendsen, Vassil Traykov, David Conen, Andrzej Lubiński, Tim Friede, Frieder Braunschweig, Georg Schmidt, Josep Brugada, Markus Zabel, Lars Lüthje, Stefan Kääb, Christian Sticherling, Tchavdar N. Shalganov, Anton E. Tuinenburg, Svetoslav Iovev, Gabriela Kaliska, Heikki V. Huikuri, Rik Willems, Janko Szavits Nossan, Gerd Hasenfuß, Robert Hatala, Stefan N. Willich, Simon Schlögl, Jim Hansen, Sandro Brusich, Milos Taborsky, Marc A. Vos, Béla Merkely, Vasil Velchev, Leonard Bergau, Marek Malik, and Iwona Cygankiewicz

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Comparative effectiveness research, Guideline, 030204 cardiovascular system & hematology, medicine.disease, Implantable cardioverter-defibrillator, 3. Good health, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Emergency medicine, medicine, Clinical endpoint, media_common.cataloged_instance, 030212 general & internal medicine, European union, Cardiology and Cardiovascular Medicine, business, Prospective cohort study, Cohort study, media_common
Abstract

Aims The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. Methods and results The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non-randomized control group). The primary endpoint is all-cause mortality; the co-primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost-effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12-lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions The EU-CERT-ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

Published
2018

41. Incremental value of left atrial mechanical dispersion over CHA2 DS2 -VASc score in predicting risk of thrombus formation

Author

Paulina Wejner−Mik, Jarosław D. Kasprzak, D Miskowiec, Karolina Kupczyńska, Piotr Lipiec, Błażej Michalski, and Ewa Szymczyk

Subjects
medicine.medical_specialty, Ejection fraction, Receiver operating characteristic, business.industry, Atrial fibrillation, 030204 cardiovascular system & hematology, medicine.disease, Global strain, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Ventricle, Left atrial, Internal medicine, CHA2DS2–VASc score, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Thrombus, Cardiology and Cardiovascular Medicine, business
Abstract

PURPOSE To assess the potential ability of two-dimensional speckle tracking analysis (STE) during atrial fibrillation (AF) to identify patients with LA appendage thrombi (LAAT). METHODS This study involved 93 patients with AF (39% female, 67.1 ± 9.5 years) who were referred for a clinical indication for transesophageal echocardiography (TEE). TEE revealed LAAT in 39 (42%) patients. We analyzed standard parameters of the left ventricle (LV) and LA in transthoracic echocardiography. Using STE, we assessed LV global longitudinal strain (LVGLS), peak atrial longitudinal strain (PALS), and intra-atrial asynchrony. The PALS was calculated using the global strain curve (GPALS) and as the mean of peaks derived from segmental strain curves (MPALS). RESULTS Patients were comparable with regard to the clinical data. A subgroup with LAAT had lower LV ejection fraction (LVEF) and a lower absolute value of the LVGLS, as well as greater impairment in the LA standard parameters, PALS, and asynchrony. Receiver operating characteristic curve analysis revealed that the LVEF of 30% (P

Published
2018

42. Bicuspid aortic valve morphology and its impact on aortic diameters-A systematic review with meta-analysis and meta-regression

Author

Jarosław D. Kasprzak, Paulina Wejner-Mik, Karolina Kupczyńska, Dawid Miśkowiec, Piotr Lipiec, Ewa Szymczyk, Błażej Michalski, and Karina Wierzbowska-Drabik

Subjects
Aortic valve, medicine.medical_specialty, Heart Valve Diseases, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Bicuspid aortic valve, Bicuspid Aortic Valve Disease, medicine.artery, Internal medicine, Ascending aorta, medicine, Humans, Radiology, Nuclear Medicine and imaging, Meta-regression, 030212 general & internal medicine, Aorta, business.industry, Mean age, medicine.disease, Stenosis, medicine.anatomical_structure, Echocardiography, Aortic Valve, Meta-analysis, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

AIM To evaluate the impact of the 2 most common bicuspid aortic valve (BAV) morphology patterns [right-left (RL) vs right-noncoronary (RN) cusp fusion] on the aortic diameters and the impact of gender, aortic stenosis (AS), aortic regurgitation (AR), and age on the observed effects. METHODS The PubMed databases was searched up to December 31, 2016 to identify studies investigating the morphology of BAV and aortic diameters. Inclusion criteria were as follows: the data on diameter of sinuses of Valsalva (SVD) and/or ascending aorta (AAD) and BAV morphology. The additional characteristics [gender, AS and AR (% of patients with moderate or severe AS/AR) and mean age] were collected to perform a meta-regression analysis. RESULTS A total of 12 studies with 2192 patients with indexed AAD, 15 studies with 3104 patients with nonindexed AAD and 8 studies with 1271 patients with indexed SVD, and 16 studies with 3454 patients with nonindexed SVD were included. There was no difference between RL and RN group in indexed/nonindexed AAD-mean difference (MD): 0.06 mm/m2 (95% CI: -0.65 to 0.77 mm/m2 , P = .87) and -0.06 mm (95% CI: 1.10-0.97 mm, P = .91). Differently, the RL BAV was associated with larger indexed/nonindexed SVD than RN phenotype-MD: 1.66 mm/m2 (95% CI: 0.83-2.49 mm/m2 , P

Published
2018

43. The Trichoscopy Derived Sinclair Scale: Enhancing visual assessment through quantitative trichoscopy

Author

Michal Kasprzak, Justyna Sicińska, and Rodney Sinclair

Subjects
Male, medicine.medical_specialty, Scale (ratio), Optical instrumentation, Dermoscopy, Dermatology, Score severity, Patient response, Severity of Illness Index, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Visual assessment, Humans, Medicine, integumentary system, business.industry, Alopecia, medicine.disease, Trichoscopy, Hair loss, 030220 oncology & carcinogenesis, Correlation analysis, Female, business
Abstract

Introduction The Sinclair Scale of hair midline density is commonly used in clinical dermatology practice as a tool to evaluate the severity of female pattern hair loss (synonym androgenetic alopecia, AGA) and to monitor patient response to treatment. The Sinclair Scale involves a visual evaluation of central hair parting line width, that is performed quickly and with no optical instrumentation. Another approach used to score severity of hair loss is quantitative trichoscopy. While quantitative trichoscopy is more accurate in terms of reproducibility and objectivity, it is more time-consuming. Materials and methods Patients with different stages of AGA were evaluated using both the Sinclair Scale and quantitative trichoscopy. A correlation analysis was performed between the Sinclair Scale and different parameters derived from statistical analysis of trichoscopy images. A novel parameter, cumulative hair thickness density was introduced. Results Very good correlation was observed between Sinclair Scale and the cumulative hair thickness density. The quality of correlation is sufficient to estimate Sinclair Scale from cumulative hair thickness density. A formula to calculate the 'Trichoscopy Derived Sinclair Scale' from trichoscopy statistics was derived. Discussion We propose the term 'Trichoscopy Derived Sinclair Scale' to describe the hair midline density as derived from trichoscopy and to differentiate this assessment of midline hair density from the traditional one based on visual inspection alone.

Published
2018

47. Relatedness of wildlife and livestock avian isolates of the nosocomial pathogenAcinetobacter baumanniito lineages spread in hospitals worldwide

Author

Magdalena Heindorf, Joachim Siekiera, Gottfried Wilharm, Jennifer K. Bender, Paul G. Higgins, Michael Kaatz, Harald Seifert, Katarzyna M. Żołnierowicz, Stéphanie Gagné, Suzana P. Salcedo, Sarah Leser, Olaf Ciebiera, Evelyn Skiebe, Marcin Bocheński, Torsten Semmler, Leszek Jerzak, Christiane Cuny, Stephan Fuchs, Piotr Kamiński, Yvonne Pfeifer, Udo Jäckel, Paul Brauner, Ulrike Blaschke, Andżelina Łopińska, Karin Böhland, Marie T. Poppel, Marcin Tobolka, Franziska Layer, Mariusz Kasprzak, and Christine Heider

Subjects
0301 basic medicine, Whole genome sequencing, animal structures, biology, business.industry, 030106 microbiology, Virulence, Zoology, biochemical phenomena, metabolism, and nutrition, Stork, biology.organism_classification, Microbiology, Acinetobacter baumannii, 03 medical and health sciences, 030104 developmental biology, Antibiotic resistance, Multilocus sequence typing, Livestock, business, Clade, Ecology, Evolution, Behavior and Systematics
Abstract

The natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. Here, we put forth and tested the hypothesis of avian reservoirs of A. baumannii. We screened tracheal and rectal swab samples from livestock (chicken, geese) and wild birds (white stork nestlings) and isolated A. baumannii from 3% of sampled chicken (n = 220), 8% of geese (n = 40) and 25% of white stork nestlings (n = 661). Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. Whole genome sequencing revealed the close relationship of an antibiotic-susceptible chicken isolate from Germany with a multidrug-resistant human clinical isolate from China and additional linkages between livestock isolates and human clinical isolates related to international clonal lineages. Moreover, we identified stork isolates related to human clinical isolates from the United States. Multilocus sequence typing disclosed further kinship between avian and human isolates. Avian isolates do not form a distinct clade within the phylogeny of A. baumannii, instead they diverge into different lineages. Further, we provide evidence that A. baumannii is constantly present in the habitats occupied by storks. Collectively, our study suggests A. baumannii could be a zoonotic organism that may disseminate into livestock.

Published
2017

48. Systolic longitudinal strain correlates with visual assessment of regional left ventricular function during dobutamine stress echocardiography and discriminates the segments with induced contractility impairment

Author

Jarosław D. Kasprzak, Karina Wierzbowska-Drabik, and Dawid Miśkowiec

Subjects
Adult, Male, medicine.medical_specialty, Longitudinal strain, Dobutamine stress echocardiography, Heart Ventricles, 030204 cardiovascular system & hematology, Contractility, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Visual assessment, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Ventricular function, business.industry, Diagnostic test, Mean age, Middle Aged, Anesthesia, Myocardial strain, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Echocardiography, Stress
Abstract

Background The relationship between visual and strain assessment of left ventricular (LV) function during dobutamine stress echocardiography (DSE) remains poorly investigated. We assessed systolic longitudinal strain (SLS) and strain rate (SLSR) in segments visually graded as normokinetic, hypokinetic, or akinetic at baseline (0) and peak stage (1) of DSE and compared deformation changes between segments with and without induced contractility worsening. Methods From 250 patients examined by DSE, 238 patients with diagnostic test were included, mean age of 62±9 years (105 females). Regional LV contractility was assessed visually and measured using SLS and SLSR in 4284 segments. Results The LV segments during baseline and peak stage of DSE revealed gradual decrease in absolute values of SLS (from 17.7±6.4% in normokinetic to 11.7±8.4% in akinetic segments at rest, and from 17.2±8.5% to 14.4±7.8% at peak, P 2% from baseline showed 90% and 76% sensitivity for the detection of contractility impairment. Conclusion Strain analysis quantifies segmental LV contractility not only at rest and peak DSE but may be helpful in detection of stress-induced contractility worsening.

Published
2017

49. The Trichoscopy Derived Sinclair Scale: Enhancing visual assessment through quantitative trichoscopy

Author

Kasprzak, M, Sicinska, J, Sinclair, R, Kasprzak, M, Sicinska, J, and Sinclair, R

Abstract

INTRODUCTION: The Sinclair Scale of hair midline density is commonly used in clinical dermatology practice as a tool to evaluate the severity of female pattern hair loss (synonym androgenetic alopecia, AGA) and to monitor patient response to treatment. The Sinclair Scale involves a visual evaluation of central hair parting line width, that is performed quickly and with no optical instrumentation. Another approach used to score severity of hair loss is quantitative trichoscopy. While quantitative trichoscopy is more accurate in terms of reproducibility and objectivity, it is more time-consuming. MATERIALS AND METHODS: Patients with different stages of AGA were evaluated using both the Sinclair Scale and quantitative trichoscopy. A correlation analysis was performed between the Sinclair Scale and different parameters derived from statistical analysis of trichoscopy images. A novel parameter, cumulative hair thickness density was introduced. RESULTS: Very good correlation was observed between Sinclair Scale and the cumulative hair thickness density. The quality of correlation is sufficient to estimate Sinclair Scale from cumulative hair thickness density. A formula to calculate the 'Trichoscopy Derived Sinclair Scale' from trichoscopy statistics was derived. DISCUSSION: We propose the term 'Trichoscopy Derived Sinclair Scale' to describe the hair midline density as derived from trichoscopy and to differentiate this assessment of midline hair density from the traditional one based on visual inspection alone.

Published
2019

50. The canonical central exact sequence for locally compact quantum groups

Author

Adam Skalski, Piotr M. Sołtan, and Paweł Kasprzak

Subjects
Exact sequence, Quantum group, General Mathematics, Locally compact quantum group, 010102 general mathematics, Center (category theory), Automorphism, 01 natural sciences, Combinatorics, 0103 physical sciences, 010307 mathematical physics, Compact quantum group, Locally compact space, 0101 mathematics, Invariant (mathematics), Mathematics
Abstract

For a locally compact quantum group $\mathbb{G}$ we define its center, $\mathscr{Z}(\mathbb{G})$, and its quantum group of inner automorphisms, $\mathrm{Inn}(\mathbb{G})$. We show that one obtains a natural isomorphism between $\mathrm{Inn}(\mathbb{G})$ and $\mathbb{G}/\!\mathscr{Z}(\mathbb{G})$, we characterize normal quantum subgroups of a compact quantum group as those left invariant by the action of the quantum group of inner automorphisms and discuss several examples.

Published
2016

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