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1. Amygdalar nuclei and hippocampal subfields on MRI: Test‐retest reliability of automated segmentation in old and young healthy volunteers

Author

Agnese Picco, Núria Bargalló, Antonios Drevelegas, Mira Didic, Régis Bordet, Moira Marizzoni, Bernhard W. Müller, Piero Floridi, Björn H. Schott, Michela Pievani, Giovanni B. Frisoni, Jill C. Richardson, Alberto Beltramello, Tilman Hensch, Marco Salvatore, Flavio Nobili, Pierre Payoux, Roberto Tarducci, Jorge Jovicich, Magda Tsolaki, Karl-Titus Hoffmann, Jens Wiltfang, Camillo Marra, Renaud Lopes, Jean-Philippe Ranjeva, Pieter Jelle Visser, Giulia Quattrini, Lucilla Parnetti, Manos Constantinides, Frederik Barkhof, David Bartrés-Faz, Francesca B. Pizzini, Julien Sein, Antonio Ferretti, Olivier Blin, Ute Fiedler, Luca Roccatagliata, Massimo Caulo, Andrea Soricelli, Paolo Maria Rossini, Joost P.A. Kuijer, Helene Gros-Dagnac, Marco Aiello, and Peter Schönknecht

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Automated segmentation, Hippocampal formation, Audiology, Test (assessment), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, Healthy volunteers, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Brain aging, Reliability (statistics)
Published
2020

2. Amygdalar nuclei and hippocampal subfields on MRI: Test‐retest reliability of automated segmentation in old and young healthy volunteers

Author

Quattrini, Giulia, primary, Pievani, Michela, additional, Jovicich, Jorge, additional, Aiello, Marco, additional, Bargalló, Nuria, additional, Barkhof, Frederik, additional, Bartrés‐Faz, David, additional, Beltramello, Alberto, additional, Pizzini, Francesca B, additional, Blin, Olivier, additional, Bordet, Régis, additional, Caulo, Massimo, additional, Constantinides, Manos, additional, Didic, Mira, additional, Drevelegas, Antonios, additional, Ferretti, Antonio, additional, Fiedler, Ute, additional, Floridi, Piero, additional, Gros‐Dagnac, Helene, additional, Hensch, Tilman, additional, Hoffmann, Karl‐Titus, additional, Kuijer, Joost, additional, Lopes, Renaud, additional, Marra, Camillo, additional, Müller, Bernhard W., additional, Nobili, Flavio, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Picco, Agnese, additional, Ranjeva, Jean‐Philippe, additional, Roccatagliata, Luca, additional, Rossini, Paolo Maria, additional, Salvatore, Marco, additional, Schonknecht, Peter, additional, Schott, Björn H, additional, Sein, Julien, additional, Soricelli, Andrea, additional, Tarducci, Roberto, additional, Tsolaki, Magda, additional, Visser, Pieter Jelle, additional, Wiltfang, Jens, additional, Richardson, Jill, additional, Frisoni, Giovanni B, additional, Marizzoni, Moira, additional, and Consortium, PharmaCog, additional

Published
2020
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3. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

Author

Rocco Marchitelli, Piero Floridi, Agnese Picco, Mira Didic, Manos Constantinidis, Julien Sein, Franco Alessandrini, Bernhard W. Müller, Carlo Cavaliere, Olivier Blin, Tilman Hensch, Lucilla Parnetti, Jean-Philippe Ranjeva, Antonios Drevelegas, Frederik Barkhof, Pierre Payoux, Roberto Tarducci, Jens Wiltfang, Beatriz Bosch, Magda Tsolaki, Camillo Marra, Régis Bordet, Renaud Lopes, Stéphanie Bombois, Massimo Caulo, Jorge Jovicich, Andrea Soricelli, Pieter Jelle Visser, David Bartrés-Faz, Antonio Ferretti, Núria Bargalló, Joost P.A. Kuijer, Karl-Titus Hoffmann, Moira Marizzoni, Luca Roccatagliata, Ludovico Minati, Giada Zoccatelli, Ute Fiedler, Alberto Beltramello, Helene Gros-Dagnac, Marco Aiello, Peter Schönknecht, Paolo Maria Rossini, Giovanni B. Frisoni, and Flavio Nobili

Subjects
medicine.medical_specialty, Pathology, Reproducibility, Radiological and Ultrasound Technology, Resting state fMRI, 05 social sciences, Regression analysis, Audiology, Brain mapping, 050105 experimental psychology, Regression, 03 medical and health sciences, Communication noise, 0302 clinical medicine, Neurology, medicine, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Anatomy, Psychology, 030217 neurology & neurosurgery, Reliability (statistics), Default mode network
Abstract

Understanding how to reduce the influence of physiological noise in resting state fMRI data is important for the interpretation of functional brain connectivity. Limited data is currently available to assess the performance of physiological noise correction techniques, in particular when evaluating longitudinal changes in the default mode network (DMN) of healthy elderly participants. In this 3T harmonized multisite fMRI study, we investigated how different retrospective physiological noise correction (rPNC) methods influence the within-site test-retest reliability and the across-site reproducibility consistency of DMN-derived measurements across 13 MRI sites. Elderly participants were scanned twice at least a week apart (five participants per site). The rPNC methods were: none (NPC), Tissue-based regression, PESTICA and FSL-FIX. The DMN at the single subject level was robustly identified using ICA methods in all rPNC conditions. The methods significantly affected the mean z-scores and, albeit less markedly, the cluster-size in the DMN; in particular, FSL-FIX tended to increase the DMN z-scores compared to others. Within-site test-retest reliability was consistent across sites, with no differences across rPNC methods. The absolute percent errors were in the range of 5-11% for DMN z-scores and cluster-size reliability. DMN pattern overlap was in the range 60-65%. In particular, no rPNC method showed a significant reliability improvement relative to NPC. However, FSL-FIX and Tissue-based physiological correction methods showed both similar and significant improvements of reproducibility consistency across the consortium (ICC = 0.67) for the DMN z-scores relative to NPC. Overall these findings support the use of rPNC methods like tissue-based or FSL-FIX to characterize multisite longitudinal changes of intrinsic functional connectivity. Hum Brain Mapp 37:2114-2132, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

4. IC‐P‐126: VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION

Author

Mira Didic, Tilman Hensch, Agnese Picco, Moira Marizzoni, Ute Fiedler, Stéphanie Bombois, Antonio Ferretti, Jean-Philippe Ranjeva, Robertto Tarducci, Frederik Barkhof, Camillo Marra, Federica Ribaldi, Jorge Jovicich, Joost P.A. Kuijer, Renaud Lopes, Alberto Beltramello, Antonios Drevelegas, Luca Roccatagliata, Giovanni B. Frisoni, Helene Gros-Dagnac, Carlo Cavaliere, David Bartrés-Faz, Marco Aiello, Julien Sein, Peter Schönknecht, Lucilla Parnetti, Andrea Soricelli, Clarissa Ferrari, Flavio Nobili, Karl-Titus Hoffmann, Paolo Maria Rossini, Manos Constantinides, Beatriz Bosch, Magda Tsolaki, Jens Wiltfang, Martina Montalti, Núria Bargalló, Régis Bordet, Bernhard W. Müller, Olivier Blin, Piero Floridi, Franco Alessandrini, Pierre Payoux, Pieter Jelle Visser, and Massimo Caulo

Subjects
Epidemiology, business.industry, Computer science, Health Policy, Pattern recognition, Hyperintensity, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Fully automatic, Segmentation, Neurology (clinical), Artificial intelligence, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Published
2018

5. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly

Author

Agnese Picco, Stéphanie Bombois, Nicola Salvadori, Lucilla Parnetti, Helene Gros-Dagnac, Mira Didic, Régis Bordet, Manos Constantinidis, Jorge Jovicich, Antonio Ferretti, Renaud Lopes, Jean-Philippe Ranjeva, Frederik Barkhof, Beatriz Bosch, Luca Roccatagliata, Magda Tsolaki, Giada Zoccatelli, Alberto Beltramello, Marco Aiello, Antonios Drevelegas, David Bartrés-Faz, Peter Schönknecht, Flavio Nobili, Andrea Soricelli, Camillo Marra, Julien Sein, Luigi Antelmi, Tilman Hensch, Ute Fiedler, Núria Bargalló, Bernhard W. Müller, Massimo Caulo, Giovanni B. Frisoni, Paolo Maria Rossini, Jens Wiltfang, Carlo Cavaliere, Moira Marizzoni, Pierre Payoux, Roberto Tarducci, Pieter Jelle Visser, Karl-Titus Hoffmann, Olivier Blin, Piero Floridi, Joost P.A. Kuijer, and Franco Alessandrini

Subjects
Reproducibility, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Subiculum, Hippocampus, Magnetic resonance imaging, Context (language use), Hippocampal formation, medicine.anatomical_structure, nervous system, Neurology, Gyrus, Hippocampal Fissure, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Anatomy, Nuclear medicine, business, Psychology, Neuroscience
Abstract

Recently, there has been an increased interest in the use of automatically segmented subfields of the human hippocampal formation derived from magnetic resonance imaging (MRI). However, little is known about the test-retest reproducibility of such measures, particularly in the context of multisite studies. Here, we report the reproducibility of automated Freesurfer hippocampal subfields segmentations in 65 healthy elderly enrolled in a consortium of 13 3T MRI sites (five subjects per site). Participants were scanned in two sessions (test and retest) at least one week apart. Each session included two anatomical 3D T1 MRI acquisitions harmonized in the consortium. We evaluated the test-retest reproducibility of subfields segmentation (i) to assess the effects of averaging two within-session T1 images and (ii) to compare subfields with whole hippocampus volume and spatial reliability. We found that within-session averaging of two T1 images significantly improved the reproducibility of all hippocampal subfields but not that of the whole hippocampus. Volumetric and spatial reproducibility across MRI sites were very good for the whole hippocampus, CA2-3, CA4-dentate gyrus (DG), subiculum (reproducibility error∼2% and DICE > 0.90), good for CA1 and presubiculum (reproducibility error ∼ 5% and DICE ∼ 0.90), and poorer for fimbria and hippocampal fissure (reproducibility error ∼ 15% and DICE

Published
2015

6. [P3–062]: ACROSS‐SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI‐SITE 3T STUDY

Author

Federica Ribaldi, Moira Marizzoni, Jorge Jovicich, Clarissa Ferrari, Beatriz Bosch, David Bartrés‐Faz, Bernhard W. Müller, Jens Wiltfang, Ute Fiedler, Luca Roccatagliata, Agnese Picco, Flavio Nobili, Olivier Blin, Stephanie Bombois, Renaud Lopes, Regis Bordet, Julien Sein, Jean‐Philippe Ranjeva, Mira Didic, Helene Gros‐Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Núria Bargallo, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Robertto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinides, Antonios Drevelegas, Paolo Maria Rossini, Camillo Marra, Peter Schonknecht, Tilman Hensch, Karl‐Titus Hoffmann, Joost Kuijer, Pieter Jelle Visser, Frederik Barkhof, and Giovanni B. Frisoni

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2017

7. [IC‐P‐167]: ACROSS‐SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI‐SITE 3T STUDY

Author

Jean-Philippe Ranjeva, Frederik Barkhof, Piero Floridi, Manos Constantinides, Moira Marizzoni, Massimo Caulo, Agnese Picco, Franco Alessandrini, Jorge Jovicich, Antonio Ferretti, Antonios Drevelegas, Régis Bordet, Mira Didic, Paolo Maria Rossini, Andrea Soricelli, Giada Zoccatelli, Pierre Payoux, Lucilla Parnetti, Beatriz Bosch, Magda Tsolaki, Bernhard W. Müller, Giovanni B. Frisoni, Renaud Lopes, Luca Roccatagliata, Jens Wiltfang, Clarissa Ferrari, David Bartrés-Faz, Pieter Jelle Visser, Flavio Nobili, Julien Sein, Helene Gros-Dagnac, Federica Ribaldi, Olivier Blin, Stéphanie Bombois, Tilman Hensch, Camillo Marra, Marco Aiello, Núria Bargalló, Carlo Cavaliere, Peter Schönknecht, Robertto Tarducci, Karl-Titus Hoffmann, Ute Fiedler, Alberto Beltramello, and Joost P.A. Kuijer

Subjects
0303 health sciences, Reproducibility, Epidemiology, Computer science, Health Policy, Multi site, Hyperintensity, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Segmentation, Neurology (clinical), Session (computer science), Geriatrics and Gerontology, Cartography, 030217 neurology & neurosurgery, 030304 developmental biology
Published
2017

8. IC‐P‐126: VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION

Author

Ribaldi, Federica, primary, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Montalti, Martina, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Régis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, Frisoni, Giovanni B., additional, and Marizzoni, Moira, additional

Published
2018
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9. [IC-P-167]: ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargalló, Nuria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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10. ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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11. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

Author

Marchitelli, Rocco, primary, Minati, Ludovico, additional, Marizzoni, Moira, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Oliver, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Régis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Hélène, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargalló, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Roberto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinidis, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schönknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost P., additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, Frisoni, Giovanni B., additional, and Jovicich, Jorge, additional

Published
2016
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12. Prenatally diagnosed cystic neuroblastoma

Author

F. Athanassiadou, A. Drevelegas, Maria Kourti, T. Zaramboukas, and Th. Papageorgiou

Subjects
Pediatrics, medicine.medical_specialty, Pregnancy, Oncology, business.industry, Neuroblastoma, Pediatrics, Perinatology and Child Health, medicine, MEDLINE, Hematology, Ultrasonography, business, medicine.disease
Published
2005

16. 563 ANTERIOR APPROACH TO CELIAC PLEXUS BLOCK UNDER CT GUIDANCE

Author

Vasilios Grosomanidis, Sandesha Kothari, Dimitrios G. Vasilakos, A. Drevelegas, and P. Theodosiadis

Subjects
medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, Medicine, Ct guidance, Radiology, Anterior approach, business, Celiac plexus block
Published
2006

17. Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects.

Author

Albi A, Pasternak O, Minati L, Marizzoni M, Bartrés-Faz D, Bargalló N, Bosch B, Rossini PM, Marra C, Müller B, Fiedler U, Wiltfang J, Roccatagliata L, Picco A, Nobili FM, Blin O, Sein J, Ranjeva JP, Didic M, Bombois S, Lopes R, Bordet R, Gros-Dagnac H, Payoux P, Zoccatelli G, Alessandrini F, Beltramello A, Ferretti A, Caulo M, Aiello M, Cavaliere C, Soricelli A, Parnetti L, Tarducci R, Floridi P, Tsolaki M, Constantinidis M, Drevelegas A, Frisoni G, and Jovicich J

Subjects
Aged, Aged, 80 and over, Anisotropy, Female, Healthy Volunteers, Humans, Imaging, Three-Dimensional, Longitudinal Studies, Male, Middle Aged, Reproducibility of Results, White Matter diagnostic imaging, Aging, Brain diagnostic imaging, Diffusion Tensor Imaging, Water metabolism
Abstract

Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart. We computed the reproducibility of commonly used DTI metrics (FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, and AXD: axial diffusivity), derived either using a DTI model or a FWE model. The DTI metrics were evaluated over 48 white-matter regions of the JHU-ICBM-DTI-81 white-matter labels atlas, and reproducibility errors were assessed. We found that relative to the DTI model, FWE significantly reduced reproducibility errors in most areas tested. In particular, for the FA and MD metrics, there was an average reduction of approximately 1% in the reproducibility error. The reproducibility scores did not significantly differ across sites. This study shows that FWE improves sensitivity and is thus promising for clinical applications, with the potential to identify more subtle changes. The increased reproducibility allows for smaller sample size or shorter trials in studies evaluating biomarkers of disease progression or treatment effects. Hum Brain Mapp 38:12-26, 2017. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)

Published
2017
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18. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly.

Author

Marizzoni M, Antelmi L, Bosch B, Bartrés-Faz D, Müller BW, Wiltfang J, Fiedler U, Roccatagliata L, Picco A, Nobili F, Blin O, Bombois S, Lopes R, Sein J, Ranjeva JP, Didic M, Gros-Dagnac H, Payoux P, Zoccatelli G, Alessandrini F, Beltramello A, Bargalló N, Ferretti A, Caulo M, Aiello M, Cavaliere C, Soricelli A, Salvadori N, Parnetti L, Tarducci R, Floridi P, Tsolaki M, Constantinidis M, Drevelegas A, Rossini PM, Marra C, Hoffmann KT, Hensch T, Schönknecht P, Kuijer JP, Visser PJ, Barkhof F, Bordet R, Frisoni GB, and Jovicich J

Subjects
Aged, Europe, Female, Humans, Longitudinal Studies, Male, Middle Aged, Organ Size, Reproducibility of Results, Software, Aging pathology, Hippocampus anatomy & histology, Image Processing, Computer-Assisted methods, Magnetic Resonance Imaging methods, Pattern Recognition, Automated methods
Abstract

Recently, there has been an increased interest in the use of automatically segmented subfields of the human hippocampal formation derived from magnetic resonance imaging (MRI). However, little is known about the test-retest reproducibility of such measures, particularly in the context of multisite studies. Here, we report the reproducibility of automated Freesurfer hippocampal subfields segmentations in 65 healthy elderly enrolled in a consortium of 13 3T MRI sites (five subjects per site). Participants were scanned in two sessions (test and retest) at least one week apart. Each session included two anatomical 3D T1 MRI acquisitions harmonized in the consortium. We evaluated the test-retest reproducibility of subfields segmentation (i) to assess the effects of averaging two within-session T1 images and (ii) to compare subfields with whole hippocampus volume and spatial reliability. We found that within-session averaging of two T1 images significantly improved the reproducibility of all hippocampal subfields but not that of the whole hippocampus. Volumetric and spatial reproducibility across MRI sites were very good for the whole hippocampus, CA2-3, CA4-dentate gyrus (DG), subiculum (reproducibility error∼2% and DICE > 0.90), good for CA1 and presubiculum (reproducibility error ∼ 5% and DICE ∼ 0.90), and poorer for fimbria and hippocampal fissure (reproducibility error ∼ 15% and DICE < 0.80). Spearman's correlations confirmed that test-retest reproducibility improved with volume size. Despite considerable differences of MRI scanner configurations, we found consistent hippocampal subfields volumes estimation. CA2-3, CA4-DG, and sub-CA1 (subiculum, presubiculum, and CA1 pooled together) gave test-retest reproducibility similar to the whole hippocampus. Our findings suggest that the larger hippocampal subfields volume may be reliable longitudinal markers in multisite studies., (© 2015 Wiley Periodicals, Inc.)

Published
2015
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