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WOS: 000405114700008, Objective: A genetic polymorphism of SOD1 A251G(rs2070424) is in the 3rd intron region of the SOD gene. The aim of this study was to determine the frequencies of the polymorphisms of the SOD1 A251G in a Turkish population, including 494 healthy individuals. Methods: The 494 Turkish individuals were genotyped for polymorphisms of SOD1 gene. The distribution of SOD1 A251G polymorphisms in this population was examined using a PCR-RFLP method. Genotype and allele frequencies were estimated by counting. Hardy-Weinberg equation between expected and observed genotype distributions was assessed using the X-2 test. Results: In the present study, the distribution of SOD1 A251G polymorphisms in a Turkish population including 494 (females: 278, 56.3% and males: 216, 43.7%) healthy individuals was examined. The mean age of the study population was 38.4 +/- 16.6 years (males, 39.8 +/- 17.1; females, 37.3 +/- 16.1). The observed genotype frequencies of SOD1 A251G were 86.2, 13.4 and 0.4% for AA, AG and GG, respectively. Conclusions: This study provides basic information about the allele and genotype frequency distributions of polymorphisms in the SOD1 A251G gene studied. These frequencies may be useful parameters as a reference for future studies on genetic basis of various diseases and cancer susceptibility.

WOS: 000307443500005, Objectives: To determine whether oxidative stress plays a role in the pathogenesis of hydatid cyst by examining levels of total antioxidant status, total oxidant status, oxidative stress index, and activities of the enzymes paraoxonase and arylesterase in patients with hydatid cyst. Methods: Thirty patients with hydatid cyst whom were positive for indirect hemagglutination and EchinococcusgranulosusIgGELISA tests were included in the patient group. Thirty-five healthy subjects that were negative for hydatid cyst by indirect hemagglutination and Echinococcus granulosus IgG ELISA tests, and did not have any parasites on stool inspection constituted the control group. Total antioxidant status, total oxidant status levels and paraoxonase, arylesterase activities were determined using commercial kits on an autoanalyzer. Oxidative stress index was calculated from a percent ratio of total peroxide level to the total antioxidant status level. Results: Serum total antioxidant status, total oxidant status and oxidative stress index levels of patients with hydatid cyst were significantly increased compared to the control group (p