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Your search keyword '"D. Ramsoekh"' showing total 2 results
Start Over Author "D. Ramsoekh" Publisher w.b. saunders for the american gastroenterological association
2 results on '"D. Ramsoekh"'

1. Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients.

Author

Simsek M, Meijer B, Ramsoekh D, Bouma G, van der Wouden EJ, den Hartog B, de Vries AC, Hoentjen F, Dijkstra G, de Boer SY, Jansen JM, van der Meulen AE, Beukers R, Brink MA, Steinhauser T, Oldenburg B, Gilissen LP, Naber TH, Verhagen MA, de Boer NKH, and Mulder CJJ

Subjects
Adolescent, Adult, Aged, Azathioprine administration & dosage, Female, Humans, Hyperplasia chemically induced, Inflammatory Bowel Diseases complications, Male, Mercaptopurine administration & dosage, Middle Aged, Thioguanine administration & dosage, Young Adult, Azathioprine adverse effects, Hyperplasia pathology, Inflammatory Bowel Diseases drug therapy, Inflammatory Bowel Diseases pathology, Liver Diseases pathology, Mercaptopurine adverse effects, Thioguanine adverse effects
Abstract

Nodular regenerative hyperplasia (NRH) is a poorly understood liver condition, which is increasingly recognized in thiopurine-treated patients with inflammatory bowel disease (IBD). 1 It is difficult to establish an optimal approach to NRH patients, because its manifestations are highly variable (from asymptomatic to symptoms of noncirrhotic portal hypertension [NCPH]) and the prognosis is unknown. 2 The aim of this study was to identify NRH cases in IBD patients treated with azathioprine, mercaptopurine, and/or thioguanine, and to describe its clinical course., (Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.)

Published
2019
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2. Outcome of peptic ulcer bleeding, nonsteroidal anti-inflammatory drug use, and Helicobacter pylori infection.

Author

Ramsoekh D, van Leerdam ME, Rauws EA, and Tytgat GN

Subjects
Aged, Aged, 80 and over, Duodenal Ulcer drug therapy, Duodenal Ulcer microbiology, Female, Follow-Up Studies, Helicobacter Infections drug therapy, Helicobacter Infections microbiology, Humans, Male, Middle Aged, Netherlands epidemiology, Patient Admission, Peptic Ulcer Hemorrhage chemically induced, Peptic Ulcer Hemorrhage drug therapy, Peptic Ulcer Hemorrhage epidemiology, Peptic Ulcer Hemorrhage microbiology, Prevalence, Prospective Studies, Proton Pump Inhibitors, Risk Factors, Stomach Ulcer drug therapy, Stomach Ulcer microbiology, Survival Analysis, Treatment Outcome, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Helicobacter Infections complications, Helicobacter Infections epidemiology, Helicobacter pylori, Peptic Ulcer Hemorrhage etiology
Abstract

Background & Aims: NSAIDs and Helicobacter pylori are risk factors for the development of peptic ulcers. A prospective study was conducted to determine prevalence of NSAID use, H pylori infection, and outcome of peptic ulcer bleeding., Methods: In 2000, data of all 361 patients presenting with peptic ulcer bleeding were prospectively collected in a defined geographical area, including 14 hospitals, and serving a catch area of 1.68 million persons. Follow-up data after a mean of 31 months were obtained from 211 patients., Results: The overall incidence was 21.5 cases per 100,000 persons. Mean age of the group was 70.9 years, 55% were male, and 41% had severe or life-threatening comorbidity. NSAIDs were used by 52%, and in only 17% concomitant acid suppressive therapy was given. H pylori infection was tested in 64%. Of the patients tested for H pylori, 43% were positive. Twenty-three percent were H pylori negative and not using NSAIDs. Rebleeding during initial admission occurred in 19%. Mortality during initial admission was 14%. During follow-up mortality was high, 29%., Conclusions: Half of all ulcer bleeding was associated with NSAID use. Only a minority of NSAID users used concomitant acid suppressive therapy. H pylori is not assessed systematically in all patients with ulcer bleeding. Almost a quarter of the ulcers were associated with neither H pylori infection nor NSAID use. Mortality, both during hospitalization and follow-up, was substantial.

Published
2005
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