1. Phyllodes tumor of the breast clinical experience and outcomes: A retrospective cohort tertiary hospital experience.
- Author
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Alkushi A, Arabi H, Al-Riyees L, Aldakheel AM, Al Zarah R, Alhussein F, Altamimi AM, Alsulaiman YA, and Omair A
- Subjects
- Adolescent, Adult, Aged, Female, Fibroadenoma diagnosis, Fibroadenoma pathology, Follow-Up Studies, Humans, Margins of Excision, Mastectomy statistics & numerical data, Middle Aged, Mortality trends, Neoplasm Metastasis pathology, Neoplasm Recurrence, Local epidemiology, Phyllodes Tumor classification, Phyllodes Tumor ultrastructure, Predictive Value of Tests, Radiotherapy methods, Radiotherapy statistics & numerical data, Retrospective Studies, Saudi Arabia epidemiology, Tertiary Care Centers, Young Adult, Biopsy, Large-Core Needle methods, Breast Neoplasms pathology, Phyllodes Tumor diagnosis, Phyllodes Tumor surgery
- Abstract
Background: Phyllodes tumor (PT) accounts for <1% of all breast tumors worldwide. Based on their microscopic features, these tumors are classified into benign, borderline, and malignant. This study aimed at evaluating the clinical experience and the clinicopathologic features of PT., Methods: A retrospective cohort study of 46 female patients with histologically diagnosed PT. Data collection and evaluation was done on patient demographics, preoperative radiological assessment and pathology, surgical procedure, post-surgery pathological evaluation, radiation therapy (RT), and follow-up., Results: The median age at diagnosis was 42 years and young premenopausal patients (median age 35 years) had malignant PT. Forty-five patients underwent core needle biopsy (CNB) with high sensitivity and the positive predictive value (82.2% and 97.4% respectively). Thirty-nine patients (86.7%) underwent conservative surgery and 6 (13.3%) had a mastectomy. Twenty-seven (58.6%) were classified as benign, 11 (23.9%) as borderline and only 8 (17.4%) as malignant PT. Malignant PT had the greatest median tumor size (13 cm). Mortality and recurrence rates were 4.3% and 2.2% respectively. RT was administered in 6 patients (13.0%), 5 having malignant and 1 borderline PT. The metastatic rate was found to be 6.5%., Conclusion: PT are rare breast tumors with variable biologic behavior and heterogenous clinicopathological findings. Young, premenopausal women with large tumors may have malignant PT with a risk of recurrence and metastasis. Core needle biopsy is a reliable tool for diagnosis of PT with strict follow-up recommended for large tumors diagnosed as fibroadenoma on CNB. Surgical management must ensure a tumor-free margin on excision to reduce recurrence., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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