1. Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia.
- Author
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Leonidou L, Mouzaki A, Michalaki M, DeLastic AL, Kyriazopoulou V, Bassaris HP, and Gogos CA
- Subjects
- Aged, Aged, 80 and over, Cytokines blood, Female, Hospital Mortality, Humans, Hyperglycemia etiology, Interleukin-10 biosynthesis, Interleukin-10 blood, Interleukin-6 biosynthesis, Interleukin-6 blood, Male, Middle Aged, Sepsis complications, Transforming Growth Factor beta1 biosynthesis, Transforming Growth Factor beta1 blood, Tumor Necrosis Factor-alpha biosynthesis, Tumor Necrosis Factor-alpha blood, Cytokines biosynthesis, Hyperglycemia immunology, Hyperglycemia mortality, Sepsis immunology
- Abstract
Objectives: To investigate whether stress hyperglycemia affects the production of the main pro- and anti-inflammatory cytokines and the 28-day hospital mortality in patients with severe sepsis., Methods: The study included 62 patients with severe sepsis, divided in three groups according to their glycemic profile within 24h after admission: patients with stress hyperglycemia (group SH, n=16), diabetes mellitus type II (group DM, n=27), and normal glucose levels (group NG, n=19). The serum levels of the cytokines TNF-alpha, IL-6, IL-10 and TGFbeta-1 were measured within 24h after admission., Results: A higher percentage of septic patients with stress hyperglycemia died compared to diabetic patients (43.7 vs. 14.8%) and group NG (43.7 vs. 5.2%). Group SH had higher SOFA score and levels of IL-6 and IL-10 than group DM and group NG. It also had higher levels of TNF-alpha than group DM but not group NG. There was no difference in the levels of TGFbeta-1 among the three groups. Non-survivors had higher levels of IL-10, no difference was detected for IL-6, TNF-alpha, IL-10/TNF-alpha ratio and TGFbeta-1. Interleukin-10 values, mean fasting glucose values and age were found as prognostic factors associated with outcome., Conclusions: Stress hyperglycemia is associated with increased cytokine production and an adverse clinical outcome in patients with severe sepsis.
- Published
- 2007
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