1. [Doxapram. Pharmocokinetic and clinical study].
- Author
-
Tourreau A, Jeanneret A, Aiache JM, Roche G, Roche E, and Molina C
- Subjects
- Administration, Oral, Blood Pressure drug effects, Carbon Dioxide blood, Doxapram administration & dosage, Doxapram therapeutic use, Drug Evaluation, Humans, Infusions, Parenteral, Injections, Intravenous, Pulmonary Artery physiology, Respiration drug effects, Suppositories, Doxapram metabolism, Respiratory Insufficiency drug therapy
- Abstract
Two series of work are reported. The first concerns the pharmacocinetic study of the product after it was administered through different ways and the corresponding evolution of PaCO2. The second study concerns the effect on pulmonary arterial pressure, blood gases and some parameters of ventilatory mechanics, of a perfusion of 200 mg of this product over a two hours period.
- Published
- 1978