1. Subjective and biological weight-related parameters in adolescents and young adults with schizophrenia spectrum disorder under clozapine or olanzapine treatment.
- Author
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Bachmann CJ, Gebhardt S, Lehr D, Haberhausen M, Kaiser C, Otto B, and Theisen FM
- Subjects
- Adolescent, Antipsychotic Agents therapeutic use, Benzodiazepines therapeutic use, Body Image, Body Mass Index, Clozapine therapeutic use, Cross-Sectional Studies, Feeding Behavior drug effects, Female, Ghrelin blood, Humans, Hunger drug effects, Leptin blood, Male, Obesity chemically induced, Obesity psychology, Olanzapine, Physical Fitness, Schizophrenia diagnosis, Sex Factors, Social Adjustment, Young Adult, Antipsychotic Agents adverse effects, Benzodiazepines adverse effects, Body Weight drug effects, Clozapine adverse effects, Schizophrenia drug therapy, Schizophrenic Psychology
- Abstract
Objective: Administration of atypical antipsychotics often induces significant weight gain and metabolic changes. Little is known about subjective weight-related parameters in adolescent patients. Therefore, this cross-sectional, explorative study aimed to assess these parameters and their relationship with biological weight-related parameters., Method: 74 patients (mean age: 19.9 [SD ± 2.3] years; 66.2% male) with schizophrenia under clozapine or olanzapine treatment were examined. Subjective well-being, eating behavior, body perception and social functioning were assessed, using the Three-Factor-Eating-Questionnaire, FKB-20 Body Perception Questionnaire, Subjective Well-being under Neuroleptics, Short Form and Global Assessment of Functioning. Patients' biological weight-related parameters were measured as well. Gender differences as well as associations between subjective and biological weight-related parameters were evaluated., Results: Female patients reported significantly worse negative body appraisal and physical functioning than males. An elevated BMI was associated with impaired physical functioning in females and with negative body appraisal and hunger in males., Conclusions: In our sample of young patients with schizophrenia unter treatment with atypical antipsychotics, an elevated BMI was associated with impaired physical functioning and negative body appraisal, respectively. Bearing in mind the high risk of obesity in this population, the mentioned impairments should be accounted for, especially in terms of compliance and quality of life.
- Published
- 2012
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