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INTRODUCTION: The aim of this study was to evaluate the effects of ellagic acid and silibinin on changes in hematological parameters caused by ultraviolet A (UVA) and ultraviolet B (UVB) exposure in the rat model. METHODS: All of 20 rats were divided into four groups of five rats: healthy control group (C), group exposed to UV (UV), group administered ellagic acid and exposed to UV (UV+EA), and group administered silibinin and exposed to UV (UV+S). Complete blood count was performed in all rats. RESULTS: Red blood cell count (p=0.042), platelet count (p=0.017) and mean platelet volume (MPV) (p=0.047) were significantly lower in the UV-exposed group compared to control group. There was no significant difference between the UV+EA group and the UV group in terms of these parameters (p>0.05). However, red blood cell counts were significantly higher in the UV+S group when compared to UV group (p=0.043). DISCUSSION AND CONCLUSION: As a result, UV exposure to the body surface can create toxic effects, particularly on red blood cells and platelets, which are anucleate cells. Silibinin, which has strong antioxidant properties, may have protective effects on red blood cell destruction due to UV exposure.

INTRODUCTION: Nonsteroidal antiinflammatory drugs (NSAIDs) are a group of drugs that have analgesic, antipyretic and anti-inflammatory effects. Due to these properties, are also used in pregnancy. Diclofenac Sodium from this group of drugs was applied to pregnant rats and it was planned to investigate the effect of postnatal pups on the uterus by stereological methods. METHODS: Twelve Wistar Albino rats were admitted. Two groups were divided into study and sham. From the fifth day of gestation, every day for 15 days study group applied 1 mg/kg Diclofenac sodium and sham group the same amount of physiological saline. At postnatal week 4 the uterus of the pups was dissected and routine histological follow-up methods were applied. Sections were taken 5μm thick. Tissues stained with Masson's Trichrome. In the stereological measurement, was evaluated using the modified method of the Cavalieri principle. The total tissue volume ratios were assessed using the dotted area scale given in the Shetereom 1.5 version package program. RESULTS: When the volumes of the uterine epithelium and serosa layers of the study and sham groups were compared, it was found that the study group had a statistically significant decrease compared to the sham group(P