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ABSTRACT Background: Nasturtium (Indian cress, Tropaeolum majus) is known for its pharmacological value in the treatment of bacterial infections of the upper air tract and urinary bladder. However, scientific data [...]

ABSTRACT Background: Adipose tissue inflammation is tightly associated with the development of insulin resistance. Corosolic acid (CRA), a natural triterpenoid, is well known as 'phyto-insulin' due to its insulin-like activities. [...]

ABSTRACT Background: Vitexin is a flavonoid found in plants of different genus such as Vitex spp. and Crataegus spp. Despite being an important molecule present in phytomedicines and nutraceuticals, the [...]

Background: Tannin-rich plant materials are commonly used in the traditional medicine as external anti-inflammatory, antioxidant and antimicrobial agents. Plant extracts containing significant quantities of tannins are often used in the prevention and treatment of oral cavity diseases such as periodontosis or gingivitis. The contribution of pure ellagitannins to the observed anti-inflammatory activity of tannin-rich remedies is still not resolved. Purpose: The aim of the present study the study was to establish if ellagitannins and their precursor--entagalloylglucose (1) can modulate the inflammatory response of ex-vivo stimulated neutrophils. Methods: Human neutrophils were isolated from the buffy coats obtained from healthy volunteers. Neutrophils were cultivated with or without tested compounds. The influence of ellagitannins and 1 on the production and release of pro-inflammatory factors such as elastase, reactive oxygen species, interleukin-8, tumour necrosis factor alpha (TNF-α) and metalloproteinase-9 was evaluated using ELISA sets or chemical methods. The effect on surface expression of toll like receptor 4 (TLR-4) and apoptosis was also checked using flow cytometry. Results: The results showed that ellgitannins modulate the inflammatory response of human neutrophils by the inhibition of production and release of chosen cytokines and pro-inflammatory enzymes. By the induction of TNF-α ellagitannins enhance neutrophil apoptosis, which is of interest in the case of chronic inflammation within oral cavity. Ellagitannins also decrease the surface expression of TLR-4 in activated neutrophils. Conclusion: The results support the traditional use of tannin-rich products in the prevention and treatment of oral cavity diseases. The present study proves the substantial contribution of ellagitannins to the anti-inflammatory activity of tannin-rich medicinal plant materials. Keywords: Ellagi tannins Neutrophils Inflammation Periodontitis Oral cavity diseases, Introduction Ellagitannin-rich plant materials are commonly used in the traditional medicine as anti-inflammatory, antioxidant and antimicrobial agents (Evans 2009; Lipinska et al. 2014; Piwowarski et al. 2014b). Most of current [...]

ABSTRACT The aim of the study was to investigate the effects of [6]-gingerol ((S)-5-hydroxy-l-(4-hydroxy-3methoxyphenyl)-3- decanone) in experimental models of non-alcoholic steatohepatitis. HepG2 cells were exposed to 500 µmol/l oleic acid [...]

ABSTRACT Diabetic nephropathy is a complex disease that involves increased production of free radicals which is a strong stimulus for the release of pro-inflammatory factors. We evaluated the renal protective [...]

ABSTRACT Berberine, an isoquinoline alkaloid, has wide biological and pharmacological actions. Despite the promising pharmacological effects and safety of berberine, poor oral absorption due to its extremely low aqueous solubility [...]

ABSTRACT Background: Coumarins, also known as benzopyrones, are plant-derived products with several pharmacological properties, including antioxidant and anti-inflammatory activities. Based on the wide distribution of coumarin derivatives in plant-based foods [...]

ARTICLE INFO Keywords: Pistillarin 1-ribofuranosyl-s-triazin-2(1 H)-one Rubinoboletus baltouil bioassay-guided fractionation peripheral blood mononuclear cells (PBMCs) ABSTRACT Rubinoboletus ballouii is an edible mushroom wildly grown in Yunnan province, China. Up till [...]

ARTICLE INFO Keywords: Aralia continentalis (Arafiaceae) Kaurenoic acid Anti-inflammatory activity NF-kB ABSTRACT This study investigates the anti-inflammatory effects of a diterpenoid, kaurenoic acid, isolated from the root of Aralia continentalis [...]

ABSTRACT The aerial parts of Saururus chinensis (SC) have been used for the treatment of edema, fever, jaundice, and inflammatory diseases in Korean folk medicine for centuries. However, the mechanism [...]

ABSTRACT Willow herb tea or preparation are available and relatively popular in the European market, and claimed to be effective inter alia because of their anti-inflammatory activity. The present study [...]

ABSTRACT Radix of Isatis indigotica (indigowood root, IR) has been used in traditional medicine for its potential anti-inflammatory effect. The purpose of this study is to investigate the radioprotective effects [...]

ABSTRACT The present study was conducted to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both [...]

ABSTRACT The genotoxic potential of anti-inflammatory/anti-arthritic and anticancer plant based drug molecule Boswelic acids (BA) was studied by in vivo system. Systematic literature survey revealed that studies on the genotoxicity [...]

Abstract Hancornia speciosa Gomes (Apocynaceae) is a Brazilian plant traditionally employed to treat inflammatory conditions, among other uses. The chemopreventive effect of an ethanol extract from H. speciosa leaves (EHS) [...]

Abstract Budlein A has been reported to exert some analgesic and anti-inflammatory properties. In this study, we have evaluated its effect on LPS-induced leukocyte recruitment in vivo and the mechanisms [...]

Abstract Madecassoside (MA), a triterpenoid product isolated from Centella asiatica, has been described to exhibit antioxidant and anti-inflammatory activities. The present study was undertaken to determine whether madecassoside (MA) is [...]

Abstract The aim of the present study was to compare powdered rose hip with and without fruits (Rosa pseudofructus cum/sine fructibus, Rosa canina L., Rosaceae) with regard to their phytochemical [...]

Abstract Boswellic acids (BA), a natural mixture isolated from oleo gum resin of Boswellia serrata comprised of four major pentacyclic triterpene acids: β-boswellic acid (the most abundant), 3-acteyl-β-boswellic acid, 11-keto-β-boswellic [...]

Abstract The anti-inflammatory and anti-nociceptive effects and the molecular mechanisms of JCICM-6 purified extract derived from an anti-arthritic Chinese herbal formula composed of Caulis Sinomenii, Aconiti laterralis Preparata, Rhizoma Curcumae [...]

Abstract Saireito (TJ-114) is a traditional Japanese herbal medicine that has been used for treating edema and inflammation in diseases such as nephritic disease. This study investigates the effect of [...]

ABSTRACT Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses [...]

ABSTRACT Latex from Euphorbia lactea (Euphorbiaceae), a native Dominican medicinal plant, is claimed to be useful in the treatment of inflammation. Topical application of tirucallol. a tetracyclic triterpene isolated from [...]

Over last three decades, we have been actively engaged in research and development of safe and effective anti-inflammatory drugs particularly from natural sources (Singh et al., 1986, 1993, 1994a, b, [...]

Salai guggal is the gum resin from the tree Boswellia serrata. Based on studies by G.B. Singh and C.K. Atal showing anti-inflammatory activity of extracts, we studied the effect of [...]

The anti-inflammatory properties of frankincense, the gum resin derived from Boswellia species, are generally well-recognized, and frankincense extracts are frequently and increasingly used in folk medicine to cure chronic inflammatory [...]

In vitro studies revealed, that boswellic acids (BAs), the active ingredients of Boswellia serrata extract, may represent promising alternative/adjuvant agents for the treatment of inflammatory diseases and cerebral oedema. 11-Keto-β [...]

Because a pathologically prolonged and sustained activation of the complement system is implicated in a variety of inflammatory disorders, from rheumatoid arthritis and glomerulonephritis to systemic lupus erythematodes, we have [...]

Boswellia Symposium in honour of the 75th birthday of Professor Dr. H.P.T. Ammon, Emeritus Department of Pharmacology, Pharmaceutical Institute of the Eberhard-Karls University of Tubingen (Germany) For thousands of years, [...]