1. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
- Author
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Li, Xuri, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, Zhou, Jian Min, Lennartsson, Johan, Li, Hong, Luttun, Aernout, Pontén, Annica, Devy, Laetitia, Bouché, Ann, Oh, Hideyasu, Manderveld, Ann, Blacher, Silvia, Communi, David, Savi, Pierre, Bono, Françoise, Dewerchin, Mieke, Foidart, Jean-Michel, Autiero, Monica, Herbert, Jean-Marc, Collen, D, Heldin, Carl-Henrik, Eriksson, Ulf, Carmeliet, Peter, Li, Xuri, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, Zhou, Jian Min, Lennartsson, Johan, Li, Hong, Luttun, Aernout, Pontén, Annica, Devy, Laetitia, Bouché, Ann, Oh, Hideyasu, Manderveld, Ann, Blacher, Silvia, Communi, David, Savi, Pierre, Bono, Françoise, Dewerchin, Mieke, Foidart, Jean-Michel, Autiero, Monica, Herbert, Jean-Marc, Collen, D, Heldin, Carl-Henrik, Eriksson, Ulf, and Carmeliet, Peter
- Abstract
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
- Published
- 2005
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