9 results on '"Otom A"'
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2. The 2023 yearbook of Neurorestoratology
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Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Chen, Lin, Wu, Ping, Sarnowska, Anna, Otom, Ali, Xue, Mengzhou, Saberi, Hooshang, He, Xijing, Alhawamdeh, Ziad, Kuf, Damien, Hu, Jianzhong, Siniscalco, Dario, Alvarez, Edgardo O., Li, Mingchang, Sanberg, Paul R., Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Chen, Lin, Wu, Ping, Sarnowska, Anna, Otom, Ali, Xue, Mengzhou, Saberi, Hooshang, He, Xijing, Alhawamdeh, Ziad, Kuf, Damien, Hu, Jianzhong, Siniscalco, Dario, Alvarez, Edgardo O., Li, Mingchang, and Sanberg, Paul R.
- Abstract
Remarkable advancements have been made in understanding the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurological disease; in our depth of understanding neurorestorative mechanisms such as anti-inflammatory processes, immune regulation, neuromodulation, neovascularization/neural repair, and neuroprotection; and in clinical neurorestorative treatments. Multiple types of cell therapies have been reported, with some positive outcomes. Diverse forms of neurostimulation and neuromodulation as well as brain-computer interfaces have shown good therapeutic outcomes in clinical applications. Further, therapeutic neurorestorative surgery and pharmaceutic therapy have been very impressive. These fundamental achievements are helpful for understanding the pathogenesis of neurological diseases and the mechanisms of neurorestoration. Patients with neurological impairments have benefited from therapeutic progress, but some of these therapies still require confirmation in higher-level randomized clinical trials.
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- 2024
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3. Criticality of an identification standard for mesenchymal stromal cells in clinical investigations
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Huang, Hongyun, Sharma, Hari Shanker, Sanberg, Paul R., Chen, Lin, Otom, Ali, Moviglia, Gustavo A., Sarnowska, Anna, Huang, Hongyun, Sharma, Hari Shanker, Sanberg, Paul R., Chen, Lin, Otom, Ali, Moviglia, Gustavo A., and Sarnowska, Anna
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- 2024
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4. Beijing declaration of International Association of Neurorestoratology (2023 Xi'an version)
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Huang, Hongyun, Chen, Lin, Sanberg, Paul R., Dimitrijevic, Milan, Shetty, Ashok K., Sharma, Hari Shanker, Wu, Ping, Bryukhovetskiy, Andrey, Al-Zoubi, Ziad M., Chopp, Michael, Young, Wise, Saberi, Hooshang, Moviglia, Gustavo, Sarnowska, Anna, Sharma, Alok, He, Xijing, Muresanu, Dafin F., Jeon, Sang Ryong, Feng, Shiqing, Cho, Kyoung-Suok, Alvarez, Edgardo O., Kuzma-Kozakiewicz, Magdalena, Kuffler, Damien, Otom, Ali, Herrera-Marschitz, Mario, Moniche, Francisco, Koliakos, Georgios, Ao, Qiang, Guo, Xiaodong, von Wild, Klaus R. H., Cheng, Liming, Al-Zoubi, Adeeb, Zhao, Jianhua, Guo, Xiaoling, Mao, Gengsheng, Han, Fabin, Hu, Yong, Xue, Mengzhou, Song, Jinggui, Zhang, Xinzhong, Chen, Xu, Chen, Lukui, Zheng, Zuncheng, Wang, Dong, Zhang, Wenchuan, Qiao, Liyan, Xiang, Guanghong, Liu, Jing, Zhao, Robert Chunhua, Zhang, Qiqing, Huang, Hongyun, Chen, Lin, Sanberg, Paul R., Dimitrijevic, Milan, Shetty, Ashok K., Sharma, Hari Shanker, Wu, Ping, Bryukhovetskiy, Andrey, Al-Zoubi, Ziad M., Chopp, Michael, Young, Wise, Saberi, Hooshang, Moviglia, Gustavo, Sarnowska, Anna, Sharma, Alok, He, Xijing, Muresanu, Dafin F., Jeon, Sang Ryong, Feng, Shiqing, Cho, Kyoung-Suok, Alvarez, Edgardo O., Kuzma-Kozakiewicz, Magdalena, Kuffler, Damien, Otom, Ali, Herrera-Marschitz, Mario, Moniche, Francisco, Koliakos, Georgios, Ao, Qiang, Guo, Xiaodong, von Wild, Klaus R. H., Cheng, Liming, Al-Zoubi, Adeeb, Zhao, Jianhua, Guo, Xiaoling, Mao, Gengsheng, Han, Fabin, Hu, Yong, Xue, Mengzhou, Song, Jinggui, Zhang, Xinzhong, Chen, Xu, Chen, Lukui, Zheng, Zuncheng, Wang, Dong, Zhang, Wenchuan, Qiao, Liyan, Xiang, Guanghong, Liu, Jing, Zhao, Robert Chunhua, and Zhang, Qiqing
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- 2023
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5. The 2022 yearbook of neurorestoratology
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Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Saberi, Hooshang, Jeon, Sang Ryong, Guo, Xiaoling, Shetty, Ashok, Hawamdeh, Ziad, Sharma, Alok, von Wild, Klaus, Siniscalco, Dario, Sanberg, Paul R., Hu, Yong, Xue, Mengzhou, Chen, Lin, Han, Fabin, Otom, Ali, Hu, Jianzhong, Zhang, Qiqing, Huang, Hongyun, Bach, John R., Sharma, Hari Shanker, Saberi, Hooshang, Jeon, Sang Ryong, Guo, Xiaoling, Shetty, Ashok, Hawamdeh, Ziad, Sharma, Alok, von Wild, Klaus, Siniscalco, Dario, Sanberg, Paul R., Hu, Yong, Xue, Mengzhou, Chen, Lin, Han, Fabin, Otom, Ali, Hu, Jianzhong, and Zhang, Qiqing
- Abstract
There was much progress in the field of Neurorestoratology in the year of 2022. It included highlighting advances in understanding the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled in the 2022 yearbook of Neurorestoratology. There is still controversy about whether amyloid b-protein and tau protein deposition are the reasons for or the results of Alzheimer's disease (AD) pathology. The fabricated images in important key articles that speculated on the reasons for AD pathogenesis were found. Cholinergic deficiency and decrease or loss in strength of glutamatergic synapse, limited or failing bidirectional cholinergic upregulation in early cognitive impairment, or progressive posterior-to-anterior cortical cholinergic denervation could result in the appearance of AD. Exploration of neurorestorative mechanisms were found in more detail ways in neuromodulation, immunomodulation, neurogenesis, neural network or circuitry reconstruction, neuroprotection, nervous structural repair, and neuroplasticity. Several kinds of cell therapies for neurological diseases showed neurorestorative effects in open-label and/or non-randomized clinical studies or trials. However, mesenchymal stromal cells and mononuclear cells did not demonstrate neurorestorative effects or improve the quality of life for patients with neurodegenerative diseases or neurotrauma including stroke, spinal cord injury (SCI), and amyotrophic lateral sclerosis in randomized, double-blind, placebo-controlled clinical trials (RDPCTs). Clinical treatments through neurostimulation/neuromodulati on and the brain-computer/ machine interface yielded positive results in AD, Parkinson's disease, stroke, SCI, cerebral palsy, and other diseases in RDPCTs. Neurorestorative surgery, pharmaceutical neurorestorative therapy and other interventions have demonstrated neurorestorative effects for various considered incurable neurological diseases in RDPCTs. Thus, this year, a
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- 2023
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6. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
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Krystyna Domanska-Janik, Kyoung Suok Cho, Michael Chopp, Ping Wu, Milan R. Dimitrijevic, Shunji Shen, Mengzhou Xue, Zhouping Tang, Lars Wiklund, Ming Lu, Xiaofeng Yang, Shiqing Feng, Ying Li, Haitao Xi, Russell J. Andrews, Fabin Han, Alok Sharma, Yujun Hao, Hiroyuki Tanaka, Zhiwen Zhang, W. Eustace Johnson, Emad Jafar, Kai Liu, Guanghong Xiang, Zuo Luan, Bin Wang, Adeeb Al-Zoubi, Gustavo Moviglia, Lin Chen, Zun-Cheng Zheng, Xijing He, Dario Siniscalco, Daqing Li, Shaocheng Zhang, W S El Masri, Si Wei You, Tiansheng Sun, Elena R. Chernykh, Hongyun Huang, Zhicheng Zhang, Seiji Ohtori, Andrey Bryukhovetskiy, Stephen D. Skaper, Yaping Feng, Guoming Luan, Xin-Fu Zhou, Paul R. Sanberg, Qiang Ao, Qun Xue, Jinfeng Li, Xiaoling Guo, Gengsheng Mao, Hooshang Saberi, Tong Li, Hamid Mobasheri, Yunliang Wang, Qunyuan Xu, Ziad M.Al Zoubi, Yaojian Rao, Dafin F. Muresanu, Hari Shanker Sharma, Yong Hu, Liang Wu, Yingjie Lu, Ashok K. Shetty, Wise Young, Ali Otom, Huang, Hongyun, Young, Wise, Chen, Lin, Feng, Shiqing, Zhou, Xin-Fu, and Li, Tong
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0301 basic medicine ,Quality Control ,medicine.medical_specialty ,clinical application guideline neurorestoratology ,Neurologi ,Cell- och molekylärbiologi ,Biomedical Engineering ,Cell- and Tissue-Based Therapy ,lcsh:Medicine ,Meeting Report ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Intensive care medicine ,Transplantation ,business.industry ,lcsh:R ,Cell Biology ,Nerve Regeneration ,Cell and molecular biology ,030104 developmental biology ,Neurology ,cell therapy ,business ,neurorestoration ,030217 neurology & neurosurgery ,Cell and Molecular Biology - Abstract
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility. Refereed/Peer-reviewed
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- 2018
7. Review of clinical neurorestorative strategies for spinal cord injury : Exploring history and latest progresses
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Huang, Hongyun, Sharma, Hari Shanker, Chen, Lin, Otom, Ali, Al Zoubi, Ziad M., Saberi, Hooshang, Muresanu, Dafin F., He, Xijing, Huang, Hongyun, Sharma, Hari Shanker, Chen, Lin, Otom, Ali, Al Zoubi, Ziad M., Saberi, Hooshang, Muresanu, Dafin F., and He, Xijing
- Abstract
Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords "neurorestorative strategies", "spinal cord injury", "cell therapy", "neuromodulation", and "nerve bridges". Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.
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- 2018
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8. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
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Huang, Hongyun, Young, Wise, Chen, Lin, Feng, Shiqing, Al Zoubi, Ziad M., Sharma, Hari Shanker, Saberi, Hooshang, Moviglia, Gustavo A., He, Xijing, Muresanu, Dafin F., Sharma, Alok, Otom, Ali, Andrews, Russell J., Al-Zoubi, Adeeb, Bryukhovetskiy, Andrey S., Chernykh, Elena R., Domanska-Janik, Krystyna, Jafar, Emad, Johnson, W. Eustace, Li, Ying, Li, Daqing, Luan, Zuo, Mao, Gengsheng, Shetty, Ashok K., Siniscalco, Dario, Skaper, Stephen, Sun, Tiansheng, Wang, Yunliang, Wiklund, Lars, Xue, Qun, You, Si-Wei, Zheng, Zuncheng, Dimitrijevic, Milan R., El Masri, W. S., Sanberg, Paul R., Xu, Qunyuan, Luan, Guoming, Chopp, Michael, Cho, Kyoung-Suok, Zhou, Xin-Fu, Wu, Ping, Liu, Kai, Mobasheri, Hamid, Ohtori, Seiji, Tanaka, Hiroyuki, Han, Fabin, Feng, Yaping, Zhang, Shaocheng, Lu, Yingjie, Zhang, Zhicheng, Rao, Yaojian, Tang, Zhouping, Xi, Haitao, Wu, Liang, Shen, Shunji, Xue, Mengzhou, Xiang, Guanghong, Guo, Xiaoling, Yang, Xiaofeng, Hao, Yujun, Hu, Yong, Li, Jinfeng, Ao, Qiang, Wang, Bin, Zhang, Zhiwen, Lu, Ming, Li, Tong, Huang, Hongyun, Young, Wise, Chen, Lin, Feng, Shiqing, Al Zoubi, Ziad M., Sharma, Hari Shanker, Saberi, Hooshang, Moviglia, Gustavo A., He, Xijing, Muresanu, Dafin F., Sharma, Alok, Otom, Ali, Andrews, Russell J., Al-Zoubi, Adeeb, Bryukhovetskiy, Andrey S., Chernykh, Elena R., Domanska-Janik, Krystyna, Jafar, Emad, Johnson, W. Eustace, Li, Ying, Li, Daqing, Luan, Zuo, Mao, Gengsheng, Shetty, Ashok K., Siniscalco, Dario, Skaper, Stephen, Sun, Tiansheng, Wang, Yunliang, Wiklund, Lars, Xue, Qun, You, Si-Wei, Zheng, Zuncheng, Dimitrijevic, Milan R., El Masri, W. S., Sanberg, Paul R., Xu, Qunyuan, Luan, Guoming, Chopp, Michael, Cho, Kyoung-Suok, Zhou, Xin-Fu, Wu, Ping, Liu, Kai, Mobasheri, Hamid, Ohtori, Seiji, Tanaka, Hiroyuki, Han, Fabin, Feng, Yaping, Zhang, Shaocheng, Lu, Yingjie, Zhang, Zhicheng, Rao, Yaojian, Tang, Zhouping, Xi, Haitao, Wu, Liang, Shen, Shunji, Xue, Mengzhou, Xiang, Guanghong, Guo, Xiaoling, Yang, Xiaofeng, Hao, Yujun, Hu, Yong, Li, Jinfeng, Ao, Qiang, Wang, Bin, Zhang, Zhiwen, Lu, Ming, and Li, Tong
- Abstract
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.
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- 2018
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9. Consensus of Clinical Neurorestorative Progress in Patients With Complete Chronic Spinal Cord Injury
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Huang, Hongyun, Sun, Tiansheng, Chen, Lin, Moviglia, Gustavo, Chernykh, Elena, von Wild, Klaus, Deda, Haluk, Kang, Kyung-Sun, Kumar, Anand, Jeon, Sang Ryong, Zhang, Shaocheng, Brunelli, Giorgio, Bohbot, Albert, Soler, Maria Dolors, Li, Jianjun, Cristante, Alexandre Fogaca, Xi, Haitao, Onose, Gelu, Kern, Helmut, Carraro, Ugo, Saberi, Hooshang, Sharma, Hari Shanker, Sharma, Alok, He, Xijing, Muresanu, Dafin, Feng, Shiqing, Otom, Ali, Wang, Dajue, Iwatsu, Koichi, Lu, Jike, Al-Zoubi, Adeeb, Huang, Hongyun, Sun, Tiansheng, Chen, Lin, Moviglia, Gustavo, Chernykh, Elena, von Wild, Klaus, Deda, Haluk, Kang, Kyung-Sun, Kumar, Anand, Jeon, Sang Ryong, Zhang, Shaocheng, Brunelli, Giorgio, Bohbot, Albert, Soler, Maria Dolors, Li, Jianjun, Cristante, Alexandre Fogaca, Xi, Haitao, Onose, Gelu, Kern, Helmut, Carraro, Ugo, Saberi, Hooshang, Sharma, Hari Shanker, Sharma, Alok, He, Xijing, Muresanu, Dafin, Feng, Shiqing, Otom, Ali, Wang, Dajue, Iwatsu, Koichi, Lu, Jike, and Al-Zoubi, Adeeb
- Abstract
Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, "nothing can be done." The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.
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- 2014
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