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Your search keyword '"Camilleri-Podesta, Marie-Therese"' showing total 2 results
Start Over Author "Camilleri-Podesta, Marie-Therese" Publisher university of malta. medical school
2 results on '"Camilleri-Podesta, Marie-Therese"'

1. Targeting the mevalonate and mammalian target of rapamycin pathways in breast cancer

Author

Petroni, Vanessa, Fenech, Anthony G., Camilleri Podesta, Marie Therese, Grech, Godfrey, and Ninth Malta Medical School Conference

Subjects
mTOR associated protein, LST8 homolog, Statins (Cardiovascular agents), Breast -- Cancer -- Treatment -- Malta, Rapamycin, Hydroxymethylglutaryl coenzyme A reductases
Abstract

Introduction: Breast cancer is the commonest cause of cancer mortality in Maltese females. The availability of eukaryotic translation initiation factor 4E (eIF4E) is reduced by mammalian target of rapamycin (mTOR) inhibitors e.g. rapamycin and metformin. Expression of 3-hydroxy-3-methylglutarylcoenzynre A reductase (HMG-CoA reductase), the mevalonate pathway rate limiting enzyme, is regulated by eIF4E. Additionally statins e.g. simvastatin, are HMG-CoA reductase inhibitors., peer-reviewed

Published
2015

2. Differential expression of breast cancer signature genes following rapamycin treatment

Author

Petroni, Vanessa, Fenech, Anthony G., Saliba, Christian, Camilleri Podesta, Marie Therese, Baldacchino, Shawn, Grech, Godfrey, and Ninth Malta Medical School Conference

Subjects
Breast -- Cancer -- Treatment, Rapamycin -- Effectiveness, MCF-7 cells, MTOR inhibitors, Aurora Kinase A
Abstract

Introduction: Breast cancer is classified into intrinsic molecular subtypes, each relating to predictive prognostic and clinical outcomes. Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which is often deregulated in various types of cancer. mTOR inhibitors are associated with antiproliferation and apoptosis. Aim: Investigating the differential expression of breast cancer signature genes following rapamycin treatment in various breast cancer subtypes., peer-reviewed

Published
2015

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