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In this study was investigated effects of borax (BX) on inflammation markers, haematolojical parameters and total oxidant (TOS)-antioxidant status (TAS) in rats applied 3-methylcholanthrene (3-MC). In this research a total of 24 Wistar Albino rats were used. They were divided into 4 groups each containing 6 rats. 1st group was separated as a control group. 3-MC was applied twice a week first 2 weeks 25 mg/kg dose to the 2nd group with i.p. way. BX was given to 3rd group 300mg/L/day dose with drinking water during 150 days. 3-MC was applied twice a week first 2 weeks 25 mg/kg dose with i.p. way and BX were given with drinking water during 150 days to 4th group. At the end of the study blood analysis, tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) levels in 3-MC group; TOS and oxidative stress index (OSI), platelet (PLT) levels in 3-MC and 3-MC+BX groups showed significantly increases when compared to other groups. It was determined that lymphocytes % (LY%) of ever 3 groups were significantly higher; however, neutrophil % (NEU%) were significantly fewer according to control group. Haemoglobin (HGB) and hematocrit (HCT) values of 3-MC+BX groups showed significantly decrease according to other groups (P≤0.05). Mean corpusculer volume (MCV) in 3-MC and 3-MC+BX groups showed significantly decrease when compared to other groups (P≤0.05). As a result, in case of exposure to 3-MC, long-term use of BX with oral ways may not decrease oxidative stress, may changes haematolojical parameters such as, WBC, LY%, NEU%, PLT, HGB, HCT, MCV. However, these changes remain within physiological limits. Even so, in the use of BX should be considered use of iron. Furthermore, BX with the abovementioned dosage may be used to reduce the levels of TNF-α, IL-1β, lL-6 being inflammation and cancer markers. [ABSTRACT FROM AUTHOR]

The purpose of this study is to investigate the effects of sodium borate (Na2B4O7-5H2O) addition to dairy cow rations starting from prepartum period on serum Cortisol, glucose, β-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglyceride (TG), blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels. Clinically healthy eighty pregnant cows were randomly divided into two groups. Sodium borate (30 g/day) was added to the rations of the borax group (n=40) until day 21 postpartum. Blood samples were taken from all cows (n=40) on days 21,14 and 7 before parturition, at parturition and on days 7,14 and 21 after parturition. Serum Cortisol levels in the borax group were lower (P<0.05) than those in the control group, there was a decrease (P<0.05) in serum BHB, NEFA and TG levels before, at parturition and after parturition, serum BUN concentrations increased (P<0.05) in prepartum and postpartum samples in the borax group, except for prepartum days 21 and 14, AST concentrations were higher (P>0.05), on all other sampling days, and ALT levels were not affected (P>0.05). It was concluded that adding sodium borate to rations especially in the transition period in highly productive dairy breeds might be an alternative to protect against negative energy imbalances. [ABSTRACT FROM AUTHOR]