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The buccal area of the oral mucosa provides an adorable channel of systemic medication distribution within the mouth mucosa. Drugs are delivered via oral mucosal layer, that has a higher first-pass metabolism and degrades gastrointestinal. The medication is immediately transmitted via the systemic circulation via the buccal drug delivery mechanism, which allows for painless administration, quick enzymatic action, high bioavailability, and reduced liver metabolism. The disadvantages of the oral drug delivery route include substantial presystemic metabolism, which causes medicines to a break down in an acidic environment due to poor absorption. Buccal delivery is an attractive administrative route due to its ease of delivery through the buccal mucosal membrane lining of the oral cavity. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, variables influencing the whole process, assessment methodologies, and how to eliminate obstacles when formulating buccal drug delivery formulations.