Deprea auccana S. Leiva, Barboza & Deanna and D. physalidicalyx Leiva, Barboza & Deanna (Solanaceae) are described and illustrated. Deprea auccana inhabits Abra Patricia Private Reserve (ECOAN, Pomacochas-Nueva Cajamarca road, District Yambrasbamba, Prov. Bongará, Dept. Amazonas, Peru). This species is distinguished by the shape and size of its leaves, number of flowers per node, length of calyx lobes, homodynamous stamens, and its erect fruits with a fruiting accrescent calyx bipartite when mature. Deprea physalidicalyx S. Leiva, Barboza & Deanna inhabits in the Aguashiyacu waterfall (Tarapoto-Juanjuí road, Prov. Tarapoto, Dept. San Martín, Peru) and it is characterized by the corolla lobes deep purple on the middle and cream on the margins internally, homodynamous stamens, and the creamy berry when mature loosely enveloped by a fruiting calyx very accrescent and inflated, 3.5-4 cm long, 2.3-2.7 cm diameter. Data about geographic distribution, ecology, phenology, conservation assessment and differences with related species are included. [ABSTRACT FROM AUTHOR]