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Your search keyword '"María de la Luz Ayala-Madrigal"' showing total 2 results
Start Over Author "María de la Luz Ayala-Madrigal" Publisher universidad nacional de colombia
2 results on '"María de la Luz Ayala-Madrigal"'

1. Intra-individual somatic variation of the rs669 polymorphism of the A2M gene in patients with colorectal cancer

Author

Helen Haydee Fernanda Ramírez-Plascencia, Melva Gutiérrez-Angulo, Alexis Sayuri Suárez-Villanueva, Jorge Peregrina-Sandoval, and María de la Luz Ayala-Madrigal

Subjects
Somatic Variation, rs669, Colorectal cancer, Medicine, Medicine (General), R5-920
Abstract

Dear Editor: An intra-individual somatic variation (ISV) is described as the genetic difference among different tissues of the same individual. ISV increases with age, may not manifest a defined phenotype, and is associated with neurological, hematological, and immune disorders, especially with cancer.1 To analyze possible ISV in Mexican patients with colorectal cancer (CRC), we studied the polymorphism rs669 (c.2998 A>G, p.Ile1000Val) of the A2M gene, which encodes for the alpha-2 macroglobulin protein, a protease inhibitor involved in tumor progression and proliferation.2 This variant is located near a thioester site, which is necessary for the inhibitory function of the protein.

Published
2020
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2. Variación somática intraindividual del polimorfismo rs669 del gen A2M en pacientes con cáncer colorrectal

Author

Melva Gutiérrez-Angulo, María de la Luz Ayala-Madrigal, Alexis Sayuri Suárez-Villanueva, Jorge Peregrina-Sandoval, and Helen Haydee Fernanda Ramírez-Plascencia

Subjects
Immune system, Colorectal cancer, Somatic cell, Tumor progression, Polymorphism (computer science), medicine, General Medicine, Biology, medicine.disease, Gene, Molecular biology, Phenotype, Macroglobulin
Abstract

La variación somática intraindividual (VSI) se describe como la diferencia genética entre los tejidos de un mismo individuo. La VSI se incrementa conforme avanza la edad y se asocia con alteraciones neurológicas, hematológicas e inmunes y, de manera especial, con cáncer, aunque puede no manifestar un fenotipo definido.1Para analizar la posible VSI en pacientes mexicanos con cáncer colorrectal (CCR), Yang et al.2 estudiaron el polimorfismo rs669 (c.2998 A>G, p.Ile1000Val) del gen A2M que codifica para la proteína alfa-2 macroglobulina, una inhibidora de proteasas involucrada en la progresión y proliferación del tumor. Esta variante se localiza cerca de un sitio tioéster, necesario para la función inhibidora de la proteína.

Published
2020

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