11 results on '"Romero-Vecchione, Eduardo"'
Search Results
2. Effect of sulodexide on aortic vasodilation capacity and associated morphological changes in rats with streptozotocin-induced diabetes
- Author
-
Vásquez, José, Mathison, Yaira, Romero-Vecchione, Eduardo, and Suárez, Claudia
- Subjects
diabetes ,estreptozotocina ,disfunción endotelial ,streptozotocin ,endothelial dysfunction ,sulodexide - Abstract
La disfunción endotelial (DE) se presenta en pacientes con hipercolesterolemia, hipertensión arterial, obesidad y diabetes mellitus. Evidencias sugieren un papel de los glicosaminoglicanos en la DE. Evaluamos el efecto del sulodexide (SLD), un glicosaminoglicano utilizado en el tratamiento de la albuminuria y la enfermedad isquémica en pacientes diabéticos, sobre la relajación arterial y los cambios morfológicos en un modelo experimental de diabetes tipo 1. La diabetes se indujo a ratas Sprague Dawley administrando estreptozotocina (STZ), 60 mg/kg, i.v. Los animales fueron distribuidos en los siguientes grupos: I= control, II= diabéticas, III: control + sulodexide, IV= diabéticas + sulodexide (15 mg/kg/día s.c). A los 3 meses fueron sacrificados, las aortas extraídas para evaluar la relajación vascular inducida por acetilcolina (Ach) y nitroprusiato de sodio en anillos precontraídos con fenilefrina. Fueron evaluadas histológicamente mediante microscopía de luz y coloraciones diversas. El SLD in vitro no modificó la tensión basal de los anillos arteriales en reposo o precontraídos con fenilefrina. La diabetes disminuyó la capacidad de relajación arterial en respuesta a la Ach en un 28,8-35,1% vs control, efecto que fue prevenido por SLD. No se observó diferencia significativa en la relajación inducida por nitroprusiato sódico entre los grupos. El estudio histológico en los animales diabéticos mostró alteraciones estructurales, particularmente en la íntima y la adventicia, cambios que fueron prevenidos por el tratamiento con SLD. Nuestros resultados apoyan la potencial utilidad terapéutica del SLD en el tratamiento de la disfunción endotelial Endothelial dysfunction (ED) is observed in patients with hypercholesterolemia, arterial hypertension, obesity and diabetes mellitus. Recent evidences suggest the involvement of glycosaminoglycans(GSG) in ED. We evaluated the effect of sulodexide (SLD), a natural GSG used in albuminuria and ischemic diabetes treatment, on arterial relaxation and vascular morphological changes in a diabetic type I model. Diabetes was induced, in Sprague-Dawley rats by streptozotocine (STZ) administration, 60 mg, iv. Rats were divided into four groups; I: control, II: diabetics, III: control + SLD, IV: diabetics treated with SLD (15 mg/day). After three months, phenylephrine precontracted aortic rings were used to evaluate acetylcholine (ACh) and sodium nitroprusside (NPS) relaxation capacities. Light microscopy of aorta was done with several staining procedures. In vitro, SLD did not change smooth muscle tone in resting or phenylephrine precontracted aortic rings. In diabetic rats, ACh relaxation was 28.8-35.1% lower than in control rats. Diabetic rats treated with SLD showed aortic ACh relaxation similar to control rats. No significative statistical difference was found in endothelium-independent NPS relaxation, between the different groups. Light microscopy histological studies revealed important morphological alterations, particularly in intima and adventitia layers of aortic artery; those changes were dramatically reversed in SLD treated rats. Our experiments support the conclusion that SLD is a potential drug for improving endothelial dysfunction in diabetes
- Published
- 2010
3. Reduction of Artery Proteoglycans affinity for Ldl isolated from Smokers after E and C Vitamins Administration
- Author
-
Barón, Luz, Romero-Vecchione, Eduardo, and López, Flor
- Subjects
Oxidized LDL ,LDL oxidada ,proteoglicanos arteriales ,vitamin C ,vitamina E ,vitamin E ,atherosclerosis ,vitamina C ,artery proteoglycans - Abstract
Resumen La interacción de la LDL con proteoglicanos arteriales y la modificación oxidativa de esta lipoproteína están relacionadas con la aterogénesis. El objetivo del presente estudio fue evaluar en fumadores el efecto de la administración individual de vitamina E y de vitaminas E y C sobre la afinidad de la LDL por proteoglicanos (PGs) arteriales. Veinte sujetos sanos fumadores y diez no fumadores recibieron por vía oral placebo de ambas vitaminas por 15 días, luego recibieron 400 mg/d de vitamina E y placebo de vitamina C por 30 días y finalmente se les administró simultáneamente 400 mg/d de vitamina E y 1000 mg/d de vitamina C durante 30 días. Al final de la administración de la vitamina E, la afinidad de la LDL por PGs arteriales disminuyó 19,3% en los fumadores y 25,2% en los no fumadores. La disminución de dicha interacción con la administración simultánea de las vitaminas E y C fue de hasta un 25,6% en los fumadores y 30,1% en los no fumadores. En conclusión, la administración simultánea de las vitaminas E y C mostró un efecto sinergístico, al disminuir en mayor proporción la afinidad de la LDL por los proteoglicanos arteriales, en comparación con la administración individual de la vitamina E. Estos hallazgos indican un efecto antiaterogénico potencial de estas vitaminas antioxidantes. Abstract LDL interaction with arterial proteoglycans and its oxidative modification is closely related to atherosclerosis. The objective of the present study was to examine the effect of the individual administration of vitamin E and a combination of vitamin E and C on LDL affinity for arterial proteoglycans in smokers and non-smokers subjects. Twenty smokers and ten non- smokers healthy subjects received by the oral route placebos of vitamins E and C for 15 days; then vitamin E (400 mg/d) for 30 days and finally vitamin E plus vitamin C (1000mg/d) during the following 30 days. During the vitamin E supplementation period, the affinity of LDL for arterial proteoglycans decreased 19.3% in smokers and 25.2% in non-smokers. When the subjects received vitamin E plus vitamin C, the affinity of LDL for arterial proteoglycans decreased 25.6% and 30.1% in smokers and non-smokers respectively. In conclusion, simultaneous administration of vitamins E and C showed a synergistic effect to diminish the affinity of the LDL by arterial proteoglycans, that was greater than caused by the administration of vitamin E alone. These finding suggest a potential antiatherogenic effect of both antioxidant vitamins.
- Published
- 2004
4. Efecto del sulodexide sobre la capacidad de relajación y alteraciones estructurales de la arteria aorta en ratas diabéticas por estreptozotocina.
- Author
-
Vásquez, José, Mathison, Yaira, Romero Vecchione, Eduardo, Suárez, Claudia, Vásquez, José, Mathison, Yaira, Romero Vecchione, Eduardo, and Suárez, Claudia
- Abstract
 La disfunción endotelial (DE) se presenta en pacientes con hipercolesterolemia, hipertensión arterial, obesidad y diabetes mellitus. Evidencias sugieren un papel de los glicosaminoglicanos en la DE. Evaluamos el efecto del sulodexide (SLD), un glicosaminoglicano utilizado en el tratamiento de la albuminuria y la enfermedad isquémica en pacientes diabéticos, sobre la relajación arterial y los cambios morfológicos en un modelo experimental de diabetes tipo 1. La diabetes se indujo a ratas Sprague Dawley administrando estreptozotocina (STZ), 60 mg/kg, i.v. Los animales fueron distribuidos en los siguientes grupos: I= control, II= diabéticas, III: control + sulodexide, IV= diabéticas + sulodexide (15 mg/kg/día s.c). A los 3 meses fueron sacrifica- dos, las aortas extraídas para evaluar la relajación vascular inducida por acetil- colina (Ach) y nitroprusiato de sodio en anillos precontraídos con fenilefrina. Fueron evaluadas histológicamente mediante microscopía de luz y coloraciones diversas. El SLD in vitro no modificó la tensión basal de los anillos arteriales en reposo o precontraídos con fenilefrina. La diabetes disminuyó la capacidad de relajación arterial en respuesta a la Ach en un 28,8-35,1% vs control, efecto que fue prevenido por SLD. No se observó diferencia significativa en la relajación inducida por nitroprusiato sódico entre los grupos. El estudio histológico en los animales diabéticos mostró alteraciones estructurales, particularmente en la íntima y la adventicia, cambios que fueron prevenidos por el tratamiento con SLD. Nuestros resultados apoyan la potencial utilidad terapéutica del SLD en el tratamiento de la disfunción endotelial.
- Published
- 2013
5. Low urinary dopamine excretion associated to low sodium excretion in normotensive Piaroa Amazonian ethnia compared to urban subjects
- Author
-
Romero Vecchione, Eduardo, Vásquez, José, Lema, Gonzalo, Guerrero, Hilda, Rosa, Francisco, Bermúdez, Mélida, Romero Vecchione, Eduardo, Vásquez, José, Lema, Gonzalo, Guerrero, Hilda, Rosa, Francisco, and Bermúdez, Mélida
- Abstract
 The objective of this work was to compare urinary doparnine, noradrenaline, adrenaline. sodium and potassium excretion in a group of normotensive Piaroa Amazonic ethnia who do not use salt in their regular food intake, against a group of urban normotensive citizens known to have a high salt intake in their regular meals. Twenty adult normotensive Piaroa subjetcs living in the Amazonas forest, 11 men and 9 women, 23-72 years old, and 33 normotensive urban citizens, 25-70 years old, 17 men and 17 women, were included in the study. After a 10 min. rest, an average of three supine systolic (SBP) and diastolic (OBP) blood pressure recordings was obtained. Piaroas subjects SBP and OBP were 111.3Ó 2.9 mmHg and 62.7Ó 1.9 mmHg respectively; urban subjects SBP and OBP were 111.8 Ó 2.2 rnrnHg and 70.3 Ó 1.6 mmHg respectively. Supine heart rate was lower in Piaroas (58.0 Ó 1.8 beats/min) than in urban subjects (76.5Ó 1.9 beats/min), p < 0.05. Sodium urinary excretion was much lower in Piaroas (12.6 Ó 5.2 rnrnol/24 h) when compared to urban subjects (210.7 Ó 24.5 mmol/24 hl. p < 0.01. No difference was found in daily urinary potassium excretion between Piaroas and urban subjects (50.4 Ó 7.2 mmol/24 h vs 45.1Ó 7.4 mmol/24 h). Urinary dopamine excretion was lower in Piaroas (314.7 Ó 40.1 J..lg/24 h) in comparison to urban subjects (800.4Ó 59,2 J..lg/24h). p < 0.05. Oaily urinary noradrenaline and adrenaline excretion were 67.9 %and 85.4% respectively lower in Piaroas than in urban subjects. In conclusion, lower amounts of sodium daily intake are associated to lower kidney dopamine production in Piaroas as compared to urban subjects. Apparently indigenous tribes might require less kidney dopamine synthesis to excrete the very small amounts of salt they consume in their regular food intake. The oppositewas found in urban subjects; more kidney dopamine synthesis would be required for larger amounts of urinary sodium excretion. In this population, essential hypertension has been as
- Published
- 2013
6. Cambios producidos por la edad en las respuestas cardiovasculares reflejas
- Author
-
Romero Vecchione, Eduardo, Wessolosky, Mireya, Lupi, Javier, Vásquez, José, Velasco, Manuel, Gómez, Juanita, Romero Vecchione, Eduardo, Wessolosky, Mireya, Lupi, Javier, Vásquez, José, Velasco, Manuel, and Gómez, Juanita
- Abstract
Se estudió la influencia de la edad en las respuestas cardiovasculares reflejas al ortostatismo y a la maniobra de Valsalva en 105 sujetos adultos sanos, y la respuesta a la prueba presora al frío en 87 sujetos sanos, en un rango de edad comprendido entre 12 y 79 años, los cuales fueron estratificados por décadas para su análisis estadístico. Se incluyeron solamente sujetos sin evidencia de patología intercurrente y ninguno de los sujetos presentó obesidad ni sobrepeso. La presión sistólica y diastólica (PAS y PAD) varió entre 113,6 Ó 4,2 y 64,2 Ó 2,9 mm Hg respectivamente en el grupo 10-19 años de edad y 139,8Ó 5,0 Y79,5 Ó 3,2 mm Hg respectivamente en el grupo de 70-79 años de edad (X Ó ES). La frecuencia cardíaca en posición supina varió entre 71,2 Ó 3,2lat/min en el grupo de 10-19 años y 75,8 Ó 3,0 lat/min en el grupo de 70-79 años de edad (X Ó ES). Respuesta al ortostatismo. El cambio de posición supina a la posición de pie aumentó la presión arterial media (PAM) en 10,0 Ó 1,25 mm Hg en el grupo de 10-19 años; de esa edad en adelante, la respuesta de la población se hizo bimodal aumentando el porcentaje de personas que mostraban descenso de la PAM al ponerse de pie: 20% en el grupo de 50-59 años y 48% en el grupo de 70-79 años de edad. Los descensos de PA estuvieron en el rango de -5,3 Ó 0,6 a -12,6 Ó 1,4 mm Hg, y fueron asintomáticos. El mismo patrón de respuesta bimodal se observó en la frecuencia cardíaca. Prueba presora al frio. En el grupo de edad de 10-19 años, se produjo un aumento de la PAS y PAD de 17,6 Ó 5,0 mm Hg y 11,5 Ó 3,5 mm Hg respectivamente, patrón de respuesta que se mantuvo hasta el rango de edad de 40-49 años. A partir de la década de 50-59 años, la elevación de PAS y PAD se redujo desde 50% hasta 63% en las décadas de 60-69 y 70-79 años de edad, sin desaparición total de la respuesta. El retorno de la PAS y PAD a los niveles de pre-estimulación fue normal en todos los grupos. Maniobra de Valsalva. Esta maniobra produjo una taquicardia que c
- Published
- 2013
7. Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii.
- Author
-
Rosa, Francisco, Cedeño, Jesús, León, Luis, Estrada, Omar, Romero-Vecchione, Eduardo, Vásquez, José, Antequera, Rafael, Rosa, Francisco, Cedeño, Jesús, León, Luis, Estrada, Omar, Romero-Vecchione, Eduardo, Vásquez, José, and Antequera, Rafael
- Abstract
The crustacean nervous system is an important source of substances with diverse biological activities, particularly affecting invertebrate cardiocirculatory physiology. However, the effects of these substances on the cardiovascular system of higher vertebrates are not very well documented. The purpose of this study was to evaluate the effects of a cardioexcitatory substance (CES) isolated from the eyestalk of the shrimp Peneaus vanameii on rat cardiovascular function. The administration of a purified fraction of this substance raised mean arterial pressure by 37.33 Ó 5.00 mm Hg, pulse pressure 35.00 Ó 4.93 mm Hg and heart rate 80.00 Ó 12.83 beats/min over basal values (p < 0.01). Evaluation of the possible underlying mechanisms of this hypertensive and tachycardic effect reveled that dihydroergotamine pretreatment (20 μg/0.2 mL) reduced the effect of CES on mean blood pressure, but not on heart rate. Propranolol pretreatment (4 μg/0.2 mL) reduced the tachycardia, but not the hypertensive response. Enalapril pretreatment (5 μg/0.2 mL) did not modify the effects induced by CES on heart rate or blood pressure, and the verapamil pretreatment (1 μg/0.2 mL) reduced both cardiovascular changes by 85% (p < 0.01). These results indicate that CES isolated from the shrimp eyestalk produces hypertension and tachycardia mediated by adrenergic receptors in association to calcium channels activation.
- Published
- 2009
8. Disminución de la afinidad entre proteoglicanos arteriales y LDL aislada de fumadores y no fumadores por administración de vitaminas E y C.
- Author
-
Barón, Luz, Romero-Vecchione, Eduardo, López, Flor, Barón, Luz, Romero-Vecchione, Eduardo, and López, Flor
- Abstract
La interacción de la LDL con proteoglicanos arteriales y la modificación oxidativa de esta lipoproteína están relacionadas con la aterogénesis. El objetivo del presente estudio fue evaluar en fumadores el efecto de la administración individual de vitamina E y de vitaminas E y C sobre la afinidad de la LDL por proteoglicanos (PGs) arteriales. Veinte sujetos sanos fumadores y diez no fumadores recibieron por vía oral placebo de ambas vitaminas por 15 días, luego recibieron 400 mg/d de vitamina E y placebo de vitamina C por 30 días y finalmente se les administró simultáneamente 400 mg/d de vitamina E y 1000 mg/d de vitamina C durante 30 días. Al final de la administración de la vitamina E, la afinidad de la LDL por PGs arteriales disminuyó 19,3% en los fumadores y 25,2% en los no fumadores. La disminución de dicha interacción con la administración simultánea de las vitaminas E y C fue de hasta un 25,6% en los fumadores y 30,1% en los no fumadores. En conclusión, la administración simultánea de las vitaminas E y C mostró un efecto sinergístico, al disminuir en mayor proporción la afinidad de la LDL por los proteoglicanos arteriales, en comparación con la administración individual de la vitamina E. Estos hallazgos indican un efecto antiaterogénico potencial de estas vitaminas antioxidantes.
- Published
- 2009
9. [Effect of sulodexide on aortic vasodilation capacity and associated morphological changes in rats with streptozotocin-induced diabetes].
- Author
-
Vásquez J, Mathison Y, Romero-Vecchione E, and Suárez C
- Subjects
- Acetylcholine pharmacology, Animals, Aorta pathology, Aorta physiopathology, Aortic Diseases etiology, Aortic Diseases pathology, Aortic Diseases physiopathology, Diabetes Mellitus, Experimental pathology, Diabetes Mellitus, Experimental physiopathology, Diabetic Angiopathies etiology, Diabetic Angiopathies pathology, Diabetic Angiopathies physiopathology, Drug Evaluation, Preclinical, Endothelium, Vascular ultrastructure, Glycosaminoglycans metabolism, Glycosaminoglycans pharmacology, Hypoglycemic Agents pharmacology, Male, Nitroprusside pharmacology, Rats, Rats, Sprague-Dawley, Tunica Intima drug effects, Tunica Intima ultrastructure, Aorta drug effects, Aortic Diseases prevention & control, Diabetes Mellitus, Experimental drug therapy, Diabetic Angiopathies prevention & control, Endothelium, Vascular drug effects, Glycosaminoglycans therapeutic use, Hypoglycemic Agents therapeutic use, Vasodilation drug effects
- Abstract
Endothelial dysfunction (ED) is observed in patients with hypercholesterolemia, arterial hypertension, obesity and diabetes mellitus. Recent evidences suggest the involvement of glycosaminoglycans (GSG) in ED. We evaluated the effect of sulodexide (SLD), a natural GSG used in albuminuria and ischemic diabetes treatment, on arterial relaxation and vascular morphological changes in a diabetic type I model. Diabetes was induced, in Sprague-Dawley rats by streptozotocine (STZ) administration, 60 mg, i.v. Rats were divided into four groups; I: control, II: diabetics, III: control + SLD, IV: diabetics treated with SLD (15 mg/day). After three months, phenylephrine precontracted aortic rings were used to evaluate acetylcholine (ACh) and sodium nitroprusside (NPS) relaxation capacities. Light microscopy of aorta was done with several staining procedures. In vitro, SLD did not change smooth muscle tone in resting or phenylephrine precontracted aortic rings. In diabetic rats, ACh relaxation was 28.8-35.1% lower than in control rats. Diabetic rats treated with SLD showed aortic ACh relaxation similar to control rats. No significative statistical difference was found in endothelium-independent NPS relaxation, between the different groups. Light microscopy histological studies revealed important morphological alterations, particularly in intima and adventitia layers of aortic artery; those changes were dramatically reversed in SLD treated rats. Our experiments support the conclusion that SLD is a potential drug for improving endothelial dysfunction in diabetes.
- Published
- 2010
10. Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii.
- Author
-
Rosa F, Cedeño J, León L, Estrada O, Romero-Vecchione E, Vásquez J, and Antequera R
- Subjects
- Animal Structures chemistry, Animals, Anti-Arrhythmia Agents pharmacology, Anti-Arrhythmia Agents therapeutic use, Antihypertensive Agents pharmacology, Antihypertensive Agents therapeutic use, Blood Pressure drug effects, Calcium Channels drug effects, Cardiotonic Agents isolation & purification, Dihydroergotamine pharmacology, Dihydroergotamine therapeutic use, Drug Evaluation, Preclinical, Enalapril pharmacology, Enalapril therapeutic use, Ganglia, Invertebrate drug effects, Heart Rate drug effects, Hypertension chemically induced, Hypertension prevention & control, Male, Motor Neurons drug effects, Neuropeptides isolation & purification, Premedication, Propranolol pharmacology, Propranolol therapeutic use, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, beta drug effects, Tachycardia chemically induced, Tachycardia prevention & control, Tissue Extracts isolation & purification, Verapamil pharmacology, Verapamil therapeutic use, Cardiotonic Agents pharmacology, Hemodynamics drug effects, Neuropeptides pharmacology, Penaeidae chemistry, Tissue Extracts pharmacology
- Abstract
The crustacean nervous system is an important source of substances with diverse biological activities, particularly affecting invertebrate cardiocirculatory physiology. However, the effects of these substances on the cardiovascular system of higher vertebrates are not very well documented. The purpose of this study was to evaluate the effects of a cardioexcitatory substance (CES) isolated from the eyestalk of the shrimp Peneaus vanameii on rat cardiovascular function. The administration of a purified fraction of this substance raised mean arterial pressure by 37.33 +/- 5.00 mm Hg, pulse pressure 35.00 +/- 4.93 mm Hg and heart rate 80.00 +/- 12.83 beats/min over basal values (p < 0.01). Evaluation of the possible underlying mechanisms of this hypertensive and tachycardic effect reveled that dihydroergotamine pretreatment (20 microg/0.2 mL) reduced the effect of CES on mean blood pressure, but not on heart rate. Propranolol pretreatment (4 microg/0.2 mL) reduced the tachycardia, but not the hypertensive response. Enalapril pretreatment (5 microg/0.2 mL) did not modify the effects induced by CES on heart rate or blood pressure, and the verapamil pretreatment (1 microg/0.2 mL) reduced both cardiovascular changes by 85% (p < 0.01). These results indicate that CES isolated from the shrimp eyestalk produces hypertension and tachycardia mediated by adrenergic receptors in association to calcium channels activation.
- Published
- 2006
11. [Decrease of affinity between arterial proteoglycans and LDL isolated from smokers and non-smokers with vitamin E and C administration].
- Author
-
Barón L, Romero-Vecchione E, and López F
- Subjects
- Adult, Arteries drug effects, Female, Humans, Lipoproteins, LDL blood, Male, Middle Aged, Arteries metabolism, Ascorbic Acid pharmacology, Lipoproteins, LDL drug effects, Lipoproteins, LDL metabolism, Proteoglycans drug effects, Proteoglycans metabolism, Smoking blood, Vitamin E pharmacology
- Abstract
LDL interaction with arterial proteoglycans and its oxidative modification is closely related to atherosclerosis. The objective of the present study was to examine the effect of the individual administration of vitamin E and a combination of vitamin E and C on LDL affinity for arterial proteoglycans in smokers and non-smokers subjects. Twenty smokers and ten non-smokers healthy subjects received by the oral route placebos of vitamins E and C for 15 days; then vitamin E (400 mg/d) for 30 days and finally vitamin E plus vitamin C (1000 mg/d) during the following 30 days. During the vitamin E supplementation period, the affinity of LDL for arterial proteoglycans decreased 19.3% in smokers and 25.2% in non-smokers. When the subjects received vitamin E plus vitamin C, the affinity of LDL for arterial proteoglycans decreased 25.6% and 30.1% in smokers and non-smokers respectively. In conclusion, simultaneous administration of vitamins E and C showed a synergistic effect to diminish the affinity of the LDL by arterial proteoglycans, that was greater than caused by the administration of vitamin E alone. These finding suggest a potential antiatherogenic effect of both antioxidant vitamins.
- Published
- 2004
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