As an important equipment in the gas receiving station, LNG storage tanks is an imprortant department to guarantee the gas providing for the significant gas sectors as well as their facilities safe operation, who has the role that cannot be replaced ,LNG in the tank is flammable and explosive medium,once the tank damaged, a large number of flammable low temperature liquid will leak, nevitably have influence on the structure of prestressed concrete performance and seismic response of the rigid wall, and destructive secondary disasters may be happened. So reseaching the heat transfer of LNG outside wall during leaking and the seismic response is very necessary. This paper takes a 50000m3 overground LNG tank as the research object, using fluent software to simulate the temperature field and using ADINA to research the seismic response of outer wall, analyzes the the change rule of temperature along the thickness and height during LNG leakage, and seismic response of outer wall when leakage happened at different height, the results can provide theoretical basis for the security calculated during LNG tanks leakage.