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In this study some new compounds have been synthesized including preparation of some different Schiff bases[1-6] from the reaction benzdine with substituted of benzal-dehyde in absolute ethanol and converted into derivatives of 1,3-oxazpines(by ring clo- sure reaction (2+5) of Schiff bases with maleic anhydride in dry benzene[7-12],also the 2,3 –dihyroquinozoline-4(1H) one[13-17] were prepared. The prepared compounds were characterized by color and melting point determination, FT-IR and UV-Vis spectral analysis . Some of the prepared compounds were identified by 1H- NMR and C.H.N spectra analysis .

This study includs the synthesis of some new Amic acid and Imides,starting from the esters [S1] of Terephthalic acid which then converted toits hydrazide [S2] then to amic acid derivatives [S3-S7] and finally withimides [S8-S12]. Preparing of ester [S1] by usual esterification ofterephthalic acid with absolute ethanol in acidic medium, then hasconverted to its hydrazide [S2] by reacting it with hydrazine hydrate. Theamic acid derivatives [S3-S7] have been synthesized by the reaction ofhydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitrophthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride,tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] werealso synthesized by cyclization of amic acids derivatives using aceticacid anhydride and anhydrous sodium acetate. The synthesizedcompounds were identified by spectral methods UV, FT-IR and H1-NMR beside melting point and the purity was determined using (TLC)and some of its physical properties were measured. Some of thesecompounds were tested against four strains of bacteria (E. coli, P.ariginosa, S. aurous and S. pyogenes)

This work included the synthesis of azo dye (A1) by the reaction of diazonium salt to benzidine with salicyldehyde at (0-5) oC and synthesis of schiff base (A2-A6) through reaction substituted aromatic amine with aldehyde group in azo compound (A1) in ethanol compounds (A2-A6) and 2,3-dihydroquinozoline derivatives prepared by reaction schiff base with anthranilic acid in ethanol compounds (A7-A11), and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 as a solvent, in addition to melting point and determination a purity of TLC, This work consisted a study of biological activity for some prepared compounds against four types of pathogenic bacteria to detect their resistance to anti biotic, drugs.