1. Nonlinear relationship between erythrocyte sodium-lithium countertransport and blood pressure in man.
- Author
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Petrov VV, Britov AN, Levitsky DO, Minchenko BI, Konstantinov EN, Svidersky VD, Novikov ID, Grishenkov EA, and Lijnen PJ
- Subjects
- Adult, Analysis of Variance, Biological Transport, Active, Blood Chemical Analysis, Blood Pressure Determination, Humans, Hypertension etiology, Male, Middle Aged, Regression Analysis, Russia, Blood Pressure physiology, Erythrocytes metabolism, Hypertension blood, Lithium blood, Sodium blood
- Abstract
A relationship between erythrocyte Na+/Li(+)-countertransport activity and blood pressure was studied in a randomly selected sample (95 subjects) with full range of blood pressure, from a representative group of inhabitants of one of Moscow's districts. The mean rate of erythrocyte Na+/Li(+)- countertransport activity was higher (p < 0.01 or less) in the groups of subjects with both borderline (BH) and moderate essential hypertension (EH) as compared with the group of normotensives (NT). A positive correlation was found between the erythrocyte Na+/Li(+)- countertransport rate and age and body weight in the entire selected group. The total contribution of these confounding parameters is responsible for 20.4% of the interindividual variability of the Na+/Li(+)- countertransport activity. The individual Na+/Li(+)- countertransport values remained unchanged during at least 2 years of follow-up. A nonlinear relationship between erythrocyte Na+/Li(+)- countertransport activity and blood pressure was established in the entire group. No significant association between blood pressure and Na+/Li(+)- countertransport was seen at high and low values of these two parameters. A pronounced change in the erythrocyte Na+/Li(+)- countertransport values occurred within a narrow borderline blood pressure range.
- Published
- 1994