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The university student population is the largest adolescent group in Iran. we aimed to measure the prevalence of sexual and illicit substance use risk behaviours among university students in Tehran, Iran. This study employed a quantitative method strategy to study Iranian university students. An anonymous quantitative survey was conducted using a self-administrated questionnaire. About 392/400 (98.0%) of invited students completed the survey with an average age of 21.98 (18-35), and 58.7% male. Lifetime substance use was reported by 14.8% of participants. The most commonly used substances were grass (11 .0%), hallucinogens (4.1%), and cocaine (2.6%). Moreover, 36.7% of participants reported sexual contacts within the last 12 months. Compared to females, more males reported condom use in last sexual contact (30.7% vs. 10.0%, P < 0.005), and multiple sexual partners (40.6% vs. 16.7%, P < 0.005). About, 34 (27.2%) participant reported sex with a sex worker or a person who had a multiple sexual partner. Group sex was reported by 5.1% of participants. Illicit substance use and unprotected sex are considerably high among university students. More effective prevention programs accessible to them are needed to reduce their vulnerability to associated harms to such risk behaviours.

To assess knowledge, attitude and practice (KAP) towards HIV/AIDS and to perform HIV, HBV, HCV and HSV2 serosurveys among girls from dysfunctional families in Tehran, Iran. A standard questionnaire was used to assess participants knowledge, attitude and practice towards HIV/AIDS by pre and post- tests within a three months interval. We also performed HIV, HBV, HCV and HSV2 serostatus assessment in our study group in post- test phase. Ninety eight (52.2%) of the participants had good knowledge about HIV/AIDS before our educational intervention, after which this was raised to 133 (70.7%) (Mc Nemar’s test, P = 0.031). Importantly, 177 (94.1%) of participants were willing to be tested for HIV before counseling. There was no positive result for HIV, HBV, HCV and HSV2 serosurvey. HIV/AIDS education and counseling significantly increased knowledge, attitudes and practice of girls from dysfunctional families regardless of their HIV, HBV, HCV, or HSV2 serostatus findings.