1. Influence of perinatal factors in short- and long-term outcomes of infants born at 23 weeks of gestation.
- Author
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Miltaha HR, Fahey LM, Sajous CH, Morrison JC, and Muraskas JK
- Subjects
- Adrenal Cortex Hormones therapeutic use, Apgar Score, Cesarean Section, Chorioamnionitis epidemiology, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Pregnancy, Pregnancy, Multiple, Premature Birth ethnology, Prenatal Care, Retrospective Studies, Sex Factors, Time Factors, Birth Weight, Developmental Disabilities epidemiology, Infant Mortality, Premature Birth therapy
- Abstract
Objective: Investigate the influence of perinatal factors on short- and long-term outcomes for infants born at 23 weeks of gestation., Study Design: This is a retrospective study over a 25-year period (1987-2011) of 87 successfully resuscitated infants at 23 weeks of gestation. We investigated the effects of poor prenatal care, race, gender, chorioamnionitis, antenatal corticosteroids, delivery route/location, low 5-minute Apgar score, birth weight, and multiple births on short- and long-term outcomes., Results: The mortality rate was 43% (37/87). A total of 88% (44/50) of the survivors were followed at 2 years corrected age with 66% (29/44) diagnosed with a moderate-to-severe neurological impairment. Outborn and multiple birth infants had significantly higher mortality (p-value 0.042 and 0.006, respectively). Lack of exposure to antenatal steroids and lower birth weight significantly increased the disability score (p-value 0.042 and 0.003, respectively)., Conclusion: Multiple perinatal factors significantly influence outcomes at the threshold of viability., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Published
- 2015
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