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The article reports on 18 sonographically examined patients with clinically verified Peyronie's disease (induratio penis plastica) who underwent a basic sonographical classification according to the system of Kelami. Four weeds after the initial sonography a control study was carried out in 17 patients. 10 of these received a treatment by local instillation with Ontosein, whereas seven patients remained without treatment. In one patient an operation (Nesbit) had been performed in the meantime. 10 of the 17 examined patients presented a change of the initial findings. Seven patients out of the number of the patients who had received treatment presented a change, whereas three patients showed no change of their basic findings. The untreated group of seven patients demonstrated in three cases a change of the sonographic pattern, and four cases were unchanged. The most significant change of the sonographic appearance (treated or untreated) was an increased echogenicity of the corpora cavernosa. In some cases no plaques could be found, in one cases a new plaque developed. In two cases the initial hypoechogenic rings sign disappeared. Sonography, however, cannot prove the success of a specific therapeutic regimen, because 50% of all patients recover without treatment.