1. Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome.
- Author
-
Anhoque CF, Biccas-Neto L, Domingues SC, Teixeira AL, and Domingues RB
- Subjects
- Adult, Anxiety psychology, Case-Control Studies, Depression psychology, Female, Humans, Male, Middle Aged, Multiple Sclerosis psychology, Neuropsychological Tests, Statistics, Nonparametric, Young Adult, Cognition physiology, Cognition Disorders psychology, Demyelinating Diseases psychology, Quality of Life psychology
- Abstract
Objective: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS)., Methods: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression with Beck Anxiety (BAI) and Depression (BDI) Inventories and Neurological disability with Guy's Neurological Disability Scale (GNDS)., Results: There was a significant difference in QoL between CIS patients and controls. CIS patients had worse performance in Paced Auditory Serial Addition 2 seconds (p=0.009) and fluency tests (p=0.0038). There was a significant difference in BAI (p=0.003), but no significant difference in BDI between patients and controls. There were significant correlations between QoL measure and verbal fluency and Stroop's test., Conclusions: Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.
- Published
- 2013
- Full Text
- View/download PDF