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2 results on '"Reich RA"'

1. No association between the +874T/A single nucleotide polymorphism in the IFN-gamma gene and susceptibility to TB.

Author

Moran A, Ma X, Reich RA, and Graviss EA

Subjects
Adult, Alleles, Case-Control Studies, Chi-Square Distribution, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Texas, Genetic Predisposition to Disease, Interferon-gamma genetics, Polymorphism, Single Nucleotide, Tuberculosis genetics
Abstract

A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-gamma) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of + 874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-gamma +874T/A mutation has no association with TB susceptibility or TB disease severity.

Published
2007

2. 5' dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas.

Author

Ma X, Dou S, Wright JA, Reich RA, Teeter LD, El Sahly HM, Awe RJ, Musser JM, and Graviss EA

Subjects
Adult, Case-Control Studies, Dinucleotide Repeats genetics, Female, Genetic Predisposition to Disease genetics, HIV Infections complications, Humans, Immunity, Innate genetics, Male, Middle Aged, Texas, Tuberculosis complications, Cation Transport Proteins genetics, Polymorphism, Genetic genetics, Tuberculosis genetics, White People genetics
Abstract

Setting: Houston Tuberculosis Initiative (HTI) and Baylor College of Medicine, Houston, Texas., Objective: To further explore the association between the polymorphisms of NRAMP1 and human susceptibility/resistance to tuberculosis (TB), specifically to determine whether the reported association shown for blacks and Asians holds true for Caucasian populations., Design: In a case-control study, 135 adult Caucasian TB patients and 108 adult Caucasian HIV-seronegative non-TB controls were analyzed for the association between the polymorphisms in NRAMP1 gene and clinical TB., Results: Heterozygote at 5'(GT)n, a dinucleotide repeat polymorphism in the promoter of NRAMP1, was observed at significantly higher frequencies among HIV-negative patients with pulmonary TB (41.6%; OR 2.02; 95%CI 1.11-3.64), extra-pulmonary TB (66.7%; OR 4.80; 95%CI 1.34-17.15), and HIV-seropositive TB patients (50%; OR 3.77; 95%CI 1.33-10.66) in comparison with the controls (27.8%). Homozygotes (GT)(10,10) were over-represented among HIV-positive TB patients (18.2%; OR 6.86; 95%CI 1.55-30.21) compared to the controls (5.5%)., Conclusion: These findings suggest that the 5'(GT)n polymorphism of NRAMP1 modifies TB susceptibility in this Caucasian population, and could possibly be related to the site of infection among HIV-negative individuals and HIV-coinfected TB.

Published
2002

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