1. Erythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells
- Author
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Bahman Anvari, Valentine I. Vullev, Yadir Guerrero, Joshua M. Burns, Vicente Nuñez, and Jenny T. Mac
- Subjects
0301 basic medicine ,Near-Infrared Fluorescence Imaging ,Near-infrared spectroscopy ,technology, industry, and agriculture ,Nanotechnology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Article ,Atomic and Molecular Physics, and Optics ,In vitro ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,Cancer cell ,Fluorescence microscope ,Cancer biomarkers ,Molecular imaging ,0210 nano-technology ,Indocyanine green ,Biotechnology - Abstract
Constructs derived from mammalian cells are emerging as a new generation of nano-scale platforms for clinical imaging applications. Herein, we report successful engineering of hybrid nano-structures composed of erythrocyte-derived membranes doped with FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG), and surface-functionalized with antibodies to achieve molecular targeting. We demonstrate that these constructs can be used for targeted imaging of cancer cells in vitro. These erythrocyte-derived optical nano-probes may provide a potential platform for clinical translation, and enable molecular imaging of cancer biomarkers.
- Published
- 2016
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