1. Polar organization of collagen in human cardiac tissue revealed with polarimetric second-harmonic generation microscopy
- Author
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Virginijus Barzda, Ahmad Golaraei, Edvardas Žurauskas, Jonas Venius, Fayez Habach, Ricardas Rotomskis, and Kamdin Mirsanaye
- Subjects
0303 health sciences ,Polarity (international relations) ,Materials science ,Polarimetry ,Second-harmonic generation ,Second Harmonic Generation Microscopy ,01 natural sciences ,Article ,Atomic and Molecular Physics, and Optics ,010309 optics ,03 medical and health sciences ,0103 physical sciences ,Microscopy ,cardiovascular system ,White light ,Biophysics ,Polar ,Electrical conduction system of the heart ,030304 developmental biology ,Biotechnology - Abstract
Polarimetric second-harmonic generation (P-SHG) microscopy is used to characterize the composition and polarity of collagen fibers in various regions of human cardiac tissue. The boundary between the cardiac conduction system and myocardium is shown to possess a distinct composition of collagen compared to other regions in the heart. Moreover, collagen fibers in this region are macroscopically organized in a unipolar arrangement, which may consequently aid in effective propagation of the electrical signal through the cardiac conduction system.
- Published
- 2019