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Your search keyword '"Gomez-Sanchez MA"' showing total 3 results
Start Over Author "Gomez-Sanchez MA" Publisher the czech society of cardiology
3 results on '"Gomez-Sanchez MA"'

1. Severe pulmonary arterial hypertension due to toxic oil syndrome: a new cause of plexogenic arteriopathy.

Author

Mestre de Juan MJ, Martinez Tello FJ, Gomez Pajuelo C, Saenz de la Calzada C, Moya Mur JL, Tascon Perez JC, Lombera Romero F, and Gomez Sanchez MA

Subjects
Fatty Acids, Monounsaturated, Humans, Hypertension, Pulmonary pathology, Muscle, Smooth, Vascular pathology, Pulmonary Artery drug effects, Pulmonary Veins drug effects, Rapeseed Oil, Respiratory Distress Syndrome pathology, Syndrome, Fibromuscular Dysplasia chemically induced, Hypertension, Pulmonary chemically induced, Muscle, Smooth, Vascular drug effects, Plant Oils adverse effects, Respiratory Distress Syndrome chemically induced
Abstract

Ten patients with severe pulmonary hypertension due to Toxic Oil Syndrome (TOS) (3 men, 7 women; mean age 27.9 +/- 11.23 yrs.) are presented. The pulmonary vessels were examined with a micromorphometric technique. All patients had intimal fibrosis of the arteries and veins. Seven also had a thrombus in different stages. All arteries were shown to have medial hypertrophy. Plexiform lexions were found in eight cases. It is concluded that TOS can produce severe pulmonary hypertension histologically undistinguishable from the primary form. TOS can be added to the list of diseases causing plexogenic arteriopathy.

Published
1990

2. Acute effect of intrapulmonary enalaprilat in ten patients with severe pulmonary hypertension due to toxic oil syndrome.

Author

Gomez Pajuelo C, Gomez Sanchez MA, Alonso Gutierrez M, Lombera Romero F, Gabriel Sanchez R, Fernandez Cruz A, and Saenz de la Calzada C

Subjects
Fatty Acids, Monounsaturated, Humans, Hypertension, Pulmonary drug therapy, Injections, Intra-Arterial, Pulmonary Circulation drug effects, Pulmonary Wedge Pressure drug effects, Rapeseed Oil, Respiratory Distress Syndrome drug therapy, Syndrome, Vascular Resistance drug effects, Enalapril administration & dosage, Hypertension, Pulmonary chemically induced, Plant Oils adverse effects, Respiratory Distress Syndrome chemically induced
Abstract

Ten patients with severe pulmonary hypertension due to Toxic Oil Syndrome underwent cardiac catheterization to analyse the acute effect of intrapulmonary injection of 1.25 mg of enalaprilat. Haemodynamic parameters were obtained at basal state, 15, 30, 45 and 60 minutes after administration of the drug. Enalaprillat did not produce any statistically significant changes in pulmonary pressures and resistances or cardiac output. This lack of response is unknown but may be related to the presence of endothelial damage and fixed pulmonary vascular lesions observed at autopsy in three patients.

Published
1990

3. Dynamic pulmonary arterial hypertension: a new form of pulmonary hypertension in patients with impaired pulmonary diffusing capacity due to toxic oil syndrome.

Author

Gomez Sanchez MA, Diaz de Atauri MJ, Alonso Gutierrez M, Martin Escribano P, Saenz de la Calzada C, Gomez Pajuelo C, Izquierdo Martinez M, and Ramis Pedromingo M

Subjects
Adult, Exercise Test, Fatty Acids, Monounsaturated, Female, Humans, Male, Middle Aged, Oxygen blood, Rapeseed Oil, Spain, Syndrome, Vascular Resistance drug effects, Hypertension, Pulmonary chemically induced, Plant Oils adverse effects, Pulmonary Diffusing Capacity drug effects, Respiratory Distress Syndrome chemically induced
Abstract

The authors studied the pulmonary haemodynamic response to exercise in eleven patients with toxic oil syndrome (TOS) (mean age 38.3 +/- 15.7 years; 10 women, 1 man) and abnormal pulmonary diffusing capacity (39.1 +/- 10.3% of predicted value) without clinical evidence of pulmonary hypertension. Eight patients had normal pulmonary pressure at rest (mean PAP less than 25 mmHg) and three showed mild pulmonary hypertension. After exercise the mean PAP rose to 35.3 +/- 11.5 mmHg from a basal value of 20.72 +/- 3.8 mmHg (p less than 0.01). Only four patients did not develop pulmonary hypertension during exercise. Pulmonary artery oxygen saturation decreased from 72.9 +/- 1.9% at rest to 52.3 +/- 10.1% during exercise (p less than 0.01). In conclusion, in this subset of TOS patients, an early diagnosis of their subclinical pulmonary hypertension can be made on the basis of the presence of dyspnoea and abnormal pulmonary diffusing capacity for carbon monoxide and can be then confirmed with the exercise haemodynamic test.

Published
1990

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