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Background: We aimed to define the epidemiological characteristics of poisoning cases in children that have occurred in Antalya, a major city in the Mediterranean. Methods: The hospital records of children between the ages of 0 to 17 yr admitted to the Pediatric Emergency Department of Antalya Training and Research Hospital, Antalya, Turkey due to poisoning in a 6-year period from 2012-2017 were evaluated. Results: Overall, 1507 poisoning cases were included in the study, of which 56% were female and 44% were male. Of them, 55% were between the ages of 0 and 5 yr, 10% were between 6 and 12, and 35% were between 13 and 17 year. In the 0-5 yr group, the poisonings were mostly in boys (55.1%) and were all accidental, while in children above 13, the poisonings were mostly in girls (77.8%) and suicide-related (97.1%). The poisonings were due to medication (64.5%) and chemical substances (35.5%). Among medication poisonings, the most common agents were paracetamol (18.0%), NSAID (15.2%) and antibiotics (8.0%). The most frequent chemical substances leading to poisoning were caustic/corrosive chemicals (22.8%) pesticides (8.0%). Interventions most commonly administered were activated charcoal (60.9%), gastric lavage (38.6%) and naso-gastric catheter (36.6%). Mortality was observed in 2 cases during six years. Conclusion: Knowledge on epidemiological and clinical features of poisoning in children according to age groups, establishing drug and chemical substance safety for children, and widespread parent education shall help decreasing childhood poisoning.