1. Synthesis and Characterization of a Colloidal Novel Folic Acid–β-cyclodextrin Conjugate for Targeted Drug Delivery
- Author
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Rosanna Stancanelli, Maria C. Aversa, Carmelo Corsaro, Antonio Clementi, Antonino Mazzaglia, Jeroen Spooren, Christine O'Connor, and Mary McNamara
- Subjects
chemistry.chemical_classification ,Aqueous solution ,Cyclodextrin ,Folic acid ,Conjugates ,Dynamic NMR ,Colloids ,Supramolecular chemistry ,food and beverages ,Ethylenediamine ,General Chemistry ,Condensed Matter Physics ,Combinatorial chemistry ,Turn (biochemistry) ,chemistry.chemical_compound ,Targeted drug delivery ,chemistry ,Folic acid Conjugates ,Proton NMR ,Physical Sciences and Mathematics ,Organic chemistry ,Food Science ,Conjugate - Abstract
A novel folic acid–β-cyclodextrin (β-CD) conjugate was synthesized and preliminarily characterized by 1H NMR, ESI-MS, and MALDI-MS. 1H NMR shows the presence of α- and γ-conjugates which are generated by β-CD linkage in turn with both carboxylic functions of folic acid. Moreover ROESY evidences supramolecular interactions between the benzene ring of the folic acid and the β-CD cavity. DOSY suggests that ethylenediamine derived β-CD–folic acid forms a colloidal dispersion difficult to purify from free folic acid. An analysis of self-diffusion coefficient (Ds) of the three species (α-, γ-conjugates, and free folic acid) and relaxation times (T1 and T2) is reported to tentatively explain the colloidal behaviour of the new species in an aqueous solution.
- Published
- 2011