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This document provides a summary of a research study that explores the relationship between IDH mutation, MGMT-promoter methylation, and PRMT5 gene expression in grade 4 astrocytoma. The study found that there is a significant relationship between MGMT-promoter methylation and IDH mutation in these tumors. It also suggests that using a PRMT5 inhibitor may be beneficial in tumor regression. The document also includes a list of references related to glioblastoma, providing valuable information for researchers and individuals interested in studying this type of brain cancer. [Extracted from the article]