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1. Long-term follow-up of late chronic phase chronic myeloid leukemia patients treated with imatinib after interferon failure: a single center experience

Author

Emilia Scalzulli, Alessio Di Prima, Robin Foà, Maurizio Martelli, Marco Mancini, Gioia Colafigli, Sara Pepe, Massimo Breccia, Roberto Latagliata, and Daniela Diverio

Subjects
Oncology, tyrosin kinase inhibitors, Myeloid, Cancer Research, medicine.medical_specialty, Chronic myeloid leukemia, failure, interferon, outcome, Follow-Up Studies, Fusion Proteins, bcr-abl, Humans, Imatinib Mesylate, Interferon-alpha, Protein Kinase Inhibitors, Treatment Outcome, Antineoplastic Agents, Leukemia, Myeloid, Chronic-Phase, Long term follow up, bcr-abl, Single Center, 03 medical and health sciences, 0302 clinical medicine, Interferon, Internal medicine, medicine, Leukemia, business.industry, Fusion Proteins, Imatinib, Hematology, Chronic phase chronic myeloid leukemia, 030220 oncology & carcinogenesis, Chronic-Phase, business, 030215 immunology, medicine.drug
Abstract

We report the long-term outcome of 139 patients treated with imatinib in late chronic phase after IFN failure. Median follow-up was 16.6 years and the estimated 18-year OS was 64.8%. 18-year EFS and PFS were 69% and 64.4%, respectively. Fifty (36%) patients stopped imatinib, 72% received a second line. b2a2 transcript was associated with a significantly inferior 18-year OS (

Published
2021

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