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Morphology, hydrophilicity, degradation, mechanical properties, drug release, bacterial resistance, and cell viability are indispensable parameters for a bioactive wound dressing. In this work, the aforementioned terms between hybrid and blend nanofibrous samples based on poly (L-lactide- co -D, L-lactide) (PLDLLA) and poly (vinyl alcohol) (PVA) containing triclosan (Tri) as an antibacterial drug were investigated. The FE-SEM images showed that the presence of Tri in the hybrid and blend samples led to bimodal, and unimodal diameter size distributions. The FTIR spectra revealed that the addition of PVA caused to shift the carbonyl bond of PLDLLA in the blend sample, and DSC thermograms exhibited the immiscibility of PVA and PLDLLA polymers in the blend. Moreover, the hybrid sample showed higher hydrophilicity with water contact angle (WCA) of 53[Formula: see text] than the blend ones with WCA of 73[Formula: see text] which proved by water up-take test. In the following, the antibacterial evaluation showed better results for hybrid-Tri with the maximum growth inhibitory zones of 35 mm and 48 mm for E. coli and S. aureus , respectively. On the other hand, the hybrid nanofibrous sample showed remarkable mechanical properties (tensile stress ∼19 MPa, and Young's modulus ∼532 MPa). Finally, the SNL 76/7 fibroblast cell line culture confirmed that the hybrid-Tri nanofibrous sample had better proliferation performance than the blend-Tri sample because of the minimal cytotoxicity and maximal cell viability by MTT and acridine orange/ethidium bromide staining.

The cells as a tissue component need to viscoelastic, biocompatible, biodegradable, and wettable extracellular matrix for their biological activity. In this study, in order to prepare biomedical polyurethane elastomers with good mechanical behavior and biodegradability, a series of novel polyester-polyether- based polyurethanes (PUs) were synthesized using a two-step bulk reaction by melting pre-polymer method, taking 1,4-Butanediol (BDO) as chain extender, hexamethylene diisocyanate as the hard segment, and poly (tetramethylene ether) glycol (PTMEG) and poly (ε-caprolactone diol) (PCL-Diol) as the soft segment without a catalyst. The soft to the hard segment ratio was kept constant in all samples. Polyurethane characteristics such as thermal and mechanical properties, wettability and water adsorption, biodegradability, and cellular behavior were changed by changing the ratio of polyether diol to polyester diol composition in the soft segment. Our present work provides a new procedure for the preparation of engineered polyurethanes in surface properties and biodegradability, which could be a good candidate for bone, cartilage, and skin tissue engineering.