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Your search keyword '"thiazolylhydrazone"' showing total 2 results
Start Over Descriptor "thiazolylhydrazone" Publisher taylor & francis ltd
2 results on '"thiazolylhydrazone"'

1. Studies on hydrazone derivatives as antifungal agents.

Author

Özdemir, Ahmet, Turan-zitouni, Gulhan, Asim kaplancikli, Zafer, Demirci, Fatih, and Iscan, Gokalp

Subjects
*PATHOGENIC microorganisms, *CANDIDA albicans, *CANDIDA tropicalis, *FUNGI, *RESEARCH
Abstract

The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed. [ABSTRACT FROM AUTHOR]

Published
2008
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2. Studies on hydrazone derivatives as antifungal agents

Author

Gökalp İşcan, Gülhan Turan-Zitouni, Ahmet Özdemir, Zafer Asım Kaplancıklı, Fatih Demirci, Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Özdemir, Ahmet, Turan, Gülhan, Kaplancıklı, Zafer Asım, Demirci, Fatih, and İşcan, Gökalp

Subjects
Pharmacology, chemistry.chemical_classification, Antifungal Agents, biology, Candida glabrata, Thiazolylhydrazone, Aryl, Hydrazones, Hydrazone, General Medicine, biology.organism_classification, Candida parapsilosis, Microbiology, Candida Spp, Candida tropicalis, chemistry.chemical_compound, chemistry, Drug Resistance, Fungal, Antifungal Activity, Candida krusei, Drug Discovery, Candida zeylanoides, Candida albicans, Candida
Abstract

WOS: 000258021400004, PubMed ID: 18665994, The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.

Published
2008

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